Ibuprofen

Question 1

Drug class

Answer 1

Non-steroidal anti-inflammatory drug (NSAID)

Question 2

Pharmacology

Answer 2

Is a non-selective NSAID that inhibits the synthesis of prostaglandins resulting in analgesic, antipyretic & anti-inflammatory actions

Question 3

Metabolism

Answer 3

Metabolised by the liver & excreted mainly by the kidneys

Question 4

Indications

Answer 4

Moderate pain due to acute inflammation & tissue injury

Question 5

Contraindications

Answer 5

• Allergy and/or adverse drug reaction to any NSAID
• Current GI bleeding OR peptic ulcers
• Dehydration AND/OR hypovolaemia
• Renal impairment
• NSAID induced asthma
• Heart failure
• Pregnancy
• Angiotension converting enzyme (ACE) inhibitor OR Angiotension II receptor blocker (ARBs)
• Pts <13 OR ≥ 65yrs
• Pts taking anticoagulants
• Diuretic Rx

Question 6

Precautions

Answer 6

• Asthma
• Hepatic dysfunction
• Hx GI bleeding or peptic ulcers

Question 7

Side effects

Answer 7

• Nausea
• Dyspepsia
• GI bleeding
• Dizziness

Question 8

Presentation

Answer 8

200mg tablet

Question 9

Onset

Duration

Answer 9

O: ~15mins

D: 4-6hrs

Question 10

Routes of administration

Answer 10

Per oral (PO)

*shortly following food/milk

Question 11

Adult dosages

Answer 11

PO 200-400MG

*not within 6hrs of previous dose