Consists of the skin and accessory organs;
hair, nails, and cutaneous glands.
Integumentary System
scientific study and medical treatment of the integumentary system
Dermatology
body’s largest and heaviest organ
– Covers 1.5 to 2.0 m^2; composes 15% of body weight
Skin
Layer of the skin; it is a stratified squamous epithelium
Epidermis
Layer of the skin; connective tissue layer beneath epidermis
Dermis
Layer of the skin; connective tissue layer below dermis (not part of skin, but associated with it)
Hypodermis
Thick skin
Thin skin
Functions of the skin:
Five epidermal cell types:
Undifferentiated cells that give rise to keratinocytes
* In the deepest layer of the epidermis (stratum basale)
Stem cells
The great majority of epidermal cells, it synthesizes keratin.
Keratinocytes
Synthesize pigment melanin that shields DNA from ultraviolet radiation.
Melanocytes
Touch receptor cells associated with dermal nerve fibers. In the basal layer of the epidermis.
Tactile cells
Macrophages originating in bone marrow that guard against pathogens. Found in stratum spinosum and granulosum.
Dendritic cells
thick skin contains five strata:
A single layer of stem cells and keratinocytes resting on the basement membrane
Stratum basale (deepest epidermal layer)
Several layers of keratinocytes are joined together by desmosomes and tight junctions.
Stratum spinosum
Three to five layers of flat keratinocytes.
Stratum granulosum
Thin, pale layer found only in thick skin.
Stratum lucidum
– Several layers (up to 30) of dead, scaly, keratinized cells.
Stratum corneum (surface layer)
Keratinocytes are produced by mitosis of (1)___________ in (2)_____________ or mitosis of keratinocytes in the deepest part of (3)_____________.
Four important events occur in stratum granulosum:
____________ are upward, finger-like extensions of the dermis
Dermal papillae