lecture 10

Question 1

whats a steroid

Answer 1

a hormone molecule which control many biological events

Question 2

what are steroids deruevd from in animals

Answer 2

lanosterol

Question 3

where are steroids produced in humans

Answer 3

adrenal glands

Question 4

what steroids control inflammation

Answer 4

corticosteroids

Question 5

what do all steroids have the same

Answer 5

4 membered ring backbone - ABC are 6 membered and D is a 5 membered ring

Question 6

steroid backbone with a hydrozil is known as a

Answer 6

sterol

Question 7

what are mineralcorticosteroids

Answer 7

water steroid

Question 8

plain backbone is ____philic and __

Answer 8

lipophilic and planar(sp3 hybridisation)

Question 9

beclomatasone key feature

Answer 9

2 double bonds in the a ring

Question 10

difference between budeonside and prednisolone

Answer 10

methyl group

Question 11

what kind of core has a chiral centre got

Answer 11

lipophilic

Question 12

explain physiochemical properties of steroids and why they are orally available

Answer 12

because of their functional groups and their physiochemical properties (specific functionality which makes them orally available)

Question 13

lipinsky rule of 5 explains what

Answer 13

why steroids are physiochemically orally available - (but this isnt why they are )

Question 14

what is the lipinsky rule of 5

Answer 14

orally absorbed drugs usually observe factors which are multiples of five: mw<500, no more than 5h donor, no more than 10 acceptors, logP value of <+5

Question 15

EG of drugs which dont satisy lipinski rule of 5

Answer 15

some antibiotic, tb drugs, ciclosporins

Question 16

where is hydrocortisone absorbed

Answer 16

stomach and intestine- since it doesnt have any ionisable groups

Question 17

aliphatic OH ionisation

Answer 17

it doesnt ionise

Question 18

steroid are genetic regulators meaning

Answer 18

they have many side effects

Question 19

how do steroids work

Answer 19

act on glucocorticoid receptor and regulate the genes which control inflammation alongside those which control development and metabolism

Question 20

why is selectivity difficult with steroid drugs

Answer 20

because they all have different effects in the body

Question 21

how are steroids administered

Answer 21

orally/rectally - gr/mr or enaemae/foams