lecture 6

Question 1

what is a prodrug

Answer 1

parent molecule which is broken down to release the active form (usually by a metabolic process)

Question 2

what do carboxylic acids get converted to so that it is more soluble in water

Answer 2

salts

Question 3

what kind of drug is sulfalazine

Answer 3

prodrug

Question 4

what is sulfalazine broken down innto

Answer 4

mesalazine (the active 5-ASA)

Question 5

where does mesalazine work

Answer 5

colon

Question 6

bacterial induced cleavage of sulfasalazine to active 5-ASA lead to

Answer 6

sulfapyridine- no anti-inflammatory affect.

Question 7

(n=n) azo used for

Answer 7

colourful dye because they dont reflect natural light.if its nect to an aromatic ring they effect coagulation

Question 8

microflora in gut converts azido to

Answer 8

sulfazine

Question 9

the n=n breaks in

Answer 9

gut as the bacterial ago-reductases cleaves the bond (1 molecule to 2)

Question 10

if treating colon, how should drugs be delivered

Answer 10

orally with coating to break at pH7/ rectally

Question 11

if the pH is 2 under the pKa - a base is 100%

Answer 11

ionised

Question 12

if pH 2 above pKa a base is 100%

Answer 12

unionised

Question 13

IS pH is 2 above pKa - an acid is 100%

Answer 13

ionised

Question 14

if an pH is 2 below pka- an acid is 100%

Answer 14

unionised

Question 15

how many functional groups need to be ionised to affect absorption

Answer 15

only takes 1 group

Question 16

what does log p of 3 mean in terms of passively getting absorbed

Answer 16

fo every 1000 molecules which pass through, 1 stays behind