lecture 8

Question 1

basic process of tablet manufacturing

Answer 1

1- drug + excipients
2- mixing

Question 2

what is the aim of mixing

Answer 2

to obtain a homogenous distribution of 2 or more components whithout changes occurring

Question 3

when is mixing key

Answer 3

when very active drugs are employe

Question 4

what are the different types of mixtures (+/-/neutral)

Answer 4

positive - mix spontaneously and irreversibly (eg gas/miscible liquids)
negative- components tend to separate ( suspensions)
neutral- neither seperate nor mix (powders)

Question 5

what does a neutral mixture need to demix

Answer 5

energy input

Question 6

the lower the proportion of a component mixture affects what

Answer 6

increases difficulty to obtain same amount in each sample

Question 7

opposite process of mixing

Answer 7

segregation

Question 8

what allows segregation

Answer 8

different densities, shapes and sizes

Question 9

granulation is

Answer 9

a process where a homogenous mixture mixtures of primary powder form larger (still homogenous) particles called granules

Question 10

what does granulation allow

Answer 10

improved powder flow, prevent segregation and improve compaction ??

Question 11

wet granulation

Answer 11

powders mixed with a granulating fluid then the mass forced through a sieve - can be done in a high speed mixer or a fluidized - bed granulator

Question 12

dry granulation

Answer 12

pressure applied, intermediate product proken , sieved