Lower Extremity Flashcards

Question

A 60-year-old man with type 2 diabetes mellitus comes to the office because of a diabetic ulcer on the sole of the right foot. Treatment of the ulcer with a medial plantar artery flap is planned. Against which of the following muscles is the arterial perforator located? ## Footnote A) Adductor hallucis B) Flexor hallucis C) Lumbrical D) Plantar interosseous E) Quadratus plantae

Answer 1

The correct response is Option B. The medial plantar artery flap is elevated starting at the plantar aspect, deep to the muscular fascia. The perforator is identified between the flexor hallucis and abductor hallucis muscles. The perforator is then dissected toward its origin on the medial plantar artery in the intermuscular space.

Answer 2

The correct answer is option C. This 35-year-old man with diabetes mellitus who previously underwent kidney transplantation has a large ulcer overlying the left Achilles tendon. Because of his immunosuppressive state and concomitant diabetes mellitus, he is most likely to experience cardiovascular problems, neuropathy, and poor wound healing following any type of reconstructive surgery. However, despite these potential adverse sequelae, free tissue transfer is most appropriate for management of the ulcer. Appropriate work-up should be obtained before attempting any reconstructive procedure. Growth factor therapy will not adequately heal this large ulcer. A skin graft alone is inappropriate for coverage of exposed tendons. Because amputations often increase cardiovascular demand in patients with diabetes mellitus, they should only be used as a last resort. An amputation is also inappropriate in a young patient because it will significantly alter his ability to perform activities of daily living. In addition, the Syme's amputation is used in wound management of the forefoot and not the distal calf.

Answer 3

The correct answer is option E. According to the results of an animal in vitro study, low-pressure pulse lavage with 1% surgical soap resulted in a more significant clearing of bone-adherent bacteria than other solutions. Low-pressure lavage was defined as 14 psi of pressure with 550 pulsations per minute; the solutions were evaluated in 1% and 10% concentrations. Osteoclast and osteoblast function was also shown to be preserved more significantly with use of the 1% soap or detergent solution. In contrast, the other solutions studied were shown to have a deleterious effect on osteoclast and osteoblast function. Low-pressure lavage with chlorhexidine or povidone-iodine was associated with the greatest decrease in osteoblast and osteoclast function. The antibacterial mechanism of soap is thought to act through its micelle function. The hydrophilic ends of the soap micelle surround the bacteria, interfering with its potential for adherence to bone. High-pressure lavage should not be used because it results in a significant depth or zone of bony injury.

Answer 4

The correct response is Option B. The origin and course of the first dorsal metatarsal artery (FDMA) are key to dissecting the first or second toe and the variety of available toe flaps. This anatomy is quite variable. In two thirds of cases, this artery emanates from the dorsalis pedis artery as its distal continuation. This course can then be superficial, within, or deep to the interosseous muscle. However, in one third of patients, the metatarsal artery may arise from the deep plantar artery that communicates with the plantar arch or actually from the plantar arch itself, in which case the FDMA may be vestigial. In the latter two situations, the metatarsal artery passes plantar to the deep transverse metatarsal ligament. The proper digital arteries are the distal continuations of the FDMA. The posterior tibial artery runs longitudinally in a superficial plane to the forefoot on the plantar surface. It is the larger lateral plantar artery that travels deeply to become the plantar arterial arch.

Answer 5

The correct answer is option E. The gracilis flap is a type II muscle flap (one dominant pedicle and one secondary pedicle) that is used for pedicled and free tissue reconstructive procedures. This flap is comprised of one primary vascular pedicle, which is supplied by the profunda femoris artery via the ascending branch of the medial femoral circumflex artery and vein, and one secondary vascular pedicle, which is supplied by the superficial femoral artery and vein. The lateral femoral circumflex artery and vein supply the rectus femoris and vastus lateralis muscle flaps. The obturator artery is a branch of the internal iliac artery and divides further to give off vascular branches, primarily in the thigh.

Answer 6

The correct response is Option D. In cases in which the nerve has undergone a significant crush component, it is important to get a sense of nerve viability and recovery. The nerve conduction study at 3 weeks largely serves as a baseline study as it rarely provides more information than physical examination other than the presence of fibrillations, which indicates at least some axonal loss. The nerve conduction study at 3 weeks is not a reliable indicator of possible nerve recovery; therefore, resection and reconstruction are not advisable at this time point. The 3-month nerve conduction study is able to pick up subtle signs of recovery that may not be evident on physical examination. If at the 3-month mark there are no signs of recovery on physical examination or nerve conduction study, repair is indicated. Acute resection of a possibly viable nerve is not indicated. If the nerve were noted to be transected at the time of initial exploratory surgery, the viability of the nerve ends would not be stable until 7 to 10 days post trauma, making this a good time for definitive repair. In the scenario described, the nerve is in continuity and viability cannot be ascertained intraoperatively at 10 days; therefore, resection and reconstruction are not indicated.

Answer 7

The correct response is Option D. **Arterial ulcers** typically occur in males with atherosclerosis, often linked to cardiovascular disease, diabetes, hypertension, or smoking. Symptoms include claudication and rest pain, with leg pain improving when dependent and worsening when elevated. The ulcer base is usually non-bleeding and has a 'punched-out' appearance. Ulcers with an ankle-brachial index < 0.45 generally won't heal without revascularization. Aggressive debridement may enlarge the wound without healing potential, and continued wound care offers no long-term benefit. The clinical picture does not suggest malignant degeneration.

Answer 8

The correct response is Option C. Although the treatment of congenital talipes equinovarus (CTEV) has trended toward conservative routines of manipulation and limited surgical release (eg, Ponseti technique), surgical treatment of CTEV may be necessary in cases of delayed treatment or failure of the conservative regime. Surgical correction may be attempted via a gradual technique (Ilizarov) or as an acute correction with release of the contracted posterior and medial elements. Many acute surgical CTEV corrections can be accomplished without skin or wound difficulties; when such difficulties are anticipated, preoperative placement of tissue expanders has proven useful in allowing primary closure of the release sites with minimal morbidity. Second intention healing and split-thickness skin grafting may not be appropriate depending on the purposeful injury and potential exposure of tendons during the contracture release. Adjacent tissue transfer may be compromised by altered local anatomy, and creation of a second wound around the ankle by the donor site may threaten future surgical approaches for additional correction of the deformity. Free tissue transfer may be warranted in late correction cases with severe tissue shortage but rarely would be necessary in the setting of primary correction.

Answer 9

The correct response is Option C. The unilateral superior gluteal artery perforator flap is most appropriate for reconstruction of the area of the sacrum affected by the pressure ulcer. Perforator flaps can be based on either the superior or inferior gluteal artery. They provide adequate myocutaneous coverage and at the same time preserve the gluteal muscles on the involved side. As a result, morbidity at the donor site will be minimized, which is especially important in this patient because he is ambulatory. Although a bilateral superior/inferior gluteal myocutaneous advancement flap supplies sufficient soft-tissue coverage for pressure ulcers, harvest of the inferior and superior gluteal muscles will result in significant morbidity at the donor site. Harvest of a gluteal myocutaneous rotation flap sacrifices muscle function and also is not the procedure of choice in an ambulatory patient. Thin split-thickness skin grafts do not provide stable coverage of pressure ulcers.

Answer 10

The correct response is Option E. The anterolateral thigh (ALT) flap has proven to be one of the most versatile free tissue transfers in reconstructive surgery. Based on perforators from the descending branch of the lateral circumflex femoral artery that traverse the vastus lateralis (VL) (80%) or the septum between the rectus femoris and VL (18-20%), this flap can be fashioned as large as 10 cm wide by 25 cm long. Occasionally, no large perforator will be identified during dissection; in this circumstance, the flap may be carried on multiple perforators along with the vastus lateralis muscle. Branches of the lateral circumflex femoral artery also supply the sartorius (partial, as the supply is segmental), rectus femoris (descending branch), and tensor fascia lata (ascending branch). Vascular supply to the gluteus maximus arises from the superior and inferior gluteal arteries.

Answer 11

The correct response is Option D. The patient is at high risk for fracture nonunion and osteomyelitis. The best next course of management is operative debridement ideally along with the treating orthopedist to make judgments about bone viability and debridement and the risks and benefits of hardware removal. Enzymatic wound debridement would not address the concerns about the deeper wound issues. The role for hyperbaric oxygen in the scenario presented is not well established. Bone cultures at the time of operative debridement should be obtained; but, percutaneous core needle cultures alone would not likely be adequate to obtain best healing. Free flap coverage may be required but is not indicated at this time.

Answer 12

The correct response is Option B. **Type I**: wound ≤1 cm, minimal contamination or muscle damage **Type II**: wound 1-10 cm, moderate soft tissue injury **Type IIIA**: wound usually >10 cm, high energy, extensive soft-tissue damage, contaminated, adequate tissue for flap coverage **Type IIIB**: extensive periosteal stripping, wound requires soft tissue coverage (rotational or free flap) **Type IIIC**: vascular injury requiring vascular repair, regardless of soft tissue injury Most accurate way to grade open fractures is by intra-operative examination.

Answer 13

The correct response is Option E. The medial plantar artery flap, or instep flap, provides sensate, full-thickness glabrous skin and subcutaneous tissue that can be transferred as a pedicled or free flap. The tissue is well suited for weight-bearing areas of the foot but has also been used as a free tissue transfer for palmar defects. Because the instep donor site is non–weight-bearing, the donor site can be covered with a skin graft. The innervation of the medial instep flap comes from the medial plantar nerve, a branch of the tibial nerve.

Answer 14

Correct answer is option B. In a patient who has a 12-cm bone defect, the most appropriate management is reconstruction using a well-vascularized, uninjured segment of bone graft, such as a contralateral free vascularized fibula graft. The contralateral fibula will provide more than 20 cm of bony length. Neither allograft nor nonvascularized autograft would provide the required bone length for revascularization. For this reason, nonvascularized bone graft is also not appropriate. Vascularized iliac crest graft can be used for reconstruction in the upper and lower extremities but would not provide a large enough segment of bone graft. Because of this patient’s injuries, the ipsilateral fibula should not be used. In addition, harvest of an ipsilateral bone graft would remove the ipsilateral supplemental support.

Answer 15

The correct response is Option E. Each head of the gastrocnemius muscle is supplied by the sural artery: either the medial sural or lateral sural artery for medial and lateral gastrocnemius, respectively. The arteries arise from the popliteal artery about 3-4 cm above the head of the fibula and enter the medial and lateral heads of the gastrocnemius at about the level of the head of the fibula. The flap can be rotated to cover soft-tissue defects of the anterior distal aspect of the knee. The flap ranges from 5 to 9 cm in width and from 13 to 20 cm in length. It provides a vascular bed for a skin graft and improves the delivery of oxygen and systemic antibiotics. The other listed arteries do not supply the gastrocnemius muscles.

Answer 16

The correct response is Option E. The soleus muscle is a bipennate muscle that is located in the superficial posterior compartment of the lower extremity, deep to the gastrocnemius muscle. The soleus muscle has a medial head that originates from the posterior aspect of the tibia and a lateral head that originates from the posterior surface of the fibula. The soleus functions in plantar flexion of the foot in conjunction with the gastrocnemius as they unite to form the Achilles tendon. Branches from the popliteal artery contribute to the blood supply of the proximal soleus muscle. The soleus muscle flap is a reliable local flap for coverage of moderate-sized soft tissue defects of the middle-third of the lower extremity. It is customarily elevated as a muscle-only flap and covered with a split-thickness skin graft. Branches from the posterior tibial artery contribute to the blood supply of the medial hemisoleus muscle flap, which is more reliable when based proximally. Branches from the peroneal artery contribute to the blood supply of the lateral hemisoleus muscle. The medial sural artery is the dominant blood supply to the medial gastrocnemius muscle flap. The anterior tibial artery and the dorsalis pedis artery do not contribute to the blood supply of the medial hemisoleus flap

Answer 17

The correct response is Option B. This 28-year-old man has a markedly diminished dorsalis pedis pulse after sustaining a laceration of the anterior tibial artery when he was stabbed in the leg. Therefore, he is most likely to have numbness of the first web space of the foot on physical examination. The first web space is innervated by the deep peroneal nerve; this nerve courses within the anterior compartment of the leg with the anterior tibial artery, which becomes the dorsalis pedis artery in the foot. The dorsal aspect of the foot (with the exception of the first web space) is innervated by the superficial peroneal nerve. The lateral foot is innervated by the sural nerve, and the medial foot is innervated by the saphenous nerve. None of these nerves travels with an artery. The plantar surface of the foot is innervated by the tibial nerve, which courses within the deep posterior compartment of the leg with the posterior tibial artery.

Answer 18

The correct response is Option B. Compression of the common peroneal nerve is the third most common nerve compression syndrome (carpal tunnel syndrome is first and cubital tunnel syndrome is second) and the most common nerve compression syndrome in the lower extremity. Knee dislocations are a common cause of common peroneal nerve compression. The patient described has a chronic injury that has not caused complete paralysis or loss of sensibility. The initial injuries would likely cause scar tissue around the knee but are not sharp in nature. Compression of the common peroneal nerve would result in weakness in the anterior compartment muscles caused by slowing of conduction in the deep peroneal nerve and paresthesias to the superolateral foot caused by slowing of conduction in the superficial peroneal nerve. Compartment syndrome is caused by elevation of interstitial pressure (\>30 mmHg) in the closed fascial compartment that results in microvascular compromise often secondary to a crushing injury or a high-force trauma. As duration and magnitude of interstitial pressure increase, myoneural function is impaired and necrosis of soft tissues eventually develops. Symptoms of an anterior compartment syndrome include extreme pain out of proportion to the injury and painful plantar flexion of the foot and toes. The superficial peroneal nerve travels in and supplies the muscles of the lateral compartment of the leg. This nerve can be injured during an open reduction and internal fixation of a fracture of the ankle. A laceration of this nerve would not cause foot drop. The deep peroneal nerve travels in and supplies the muscles to the anterior compartment. Laceration of this nerve would cause foot drop but not decreased sensibility to the leg. A neurapraxia of the tibial nerve at the level of the knee would affect the plantar flexors of the foot and toes. A tibial nerve injury would also cause planar foot paresthesias, which is the opposite of what the patient described is experiencing.

Answer 19

The correct response is Option D. In the patient described, the dermatomal distribution of numbness of the middle of the dorsum of the foot suggests injury of the superficial peroneal nerve (SPN). The SPN supplies the sensation to the middle portion of the dorsum of the foot, except for the skin in the great toe web space (which is innervated by the deep peroneal nerve). The lateral malleolar nerve is a terminal branch nerve supplying the skin of the lateral malleolus. The medial plantar nerve supplies the medial three fourths of the plantar surface of the foot. The saphenous nerve travels to the dorsum of the foot, medial malleolus, and the area of the head of the first metatarsal. At the level of the ankle, the saphenous nerve is found between the medial malleolus and the anterior tibial tendon, just lateral to the saphenous vein. The sural nerve is located at an average of 7 mm posterior to the lateral malleolus and supplies sensation to the lateral aspect of the foot. A diagram is shown. According to one study, in ankle arthroscopy the risk of SPN injury is maximal in the 0 to 3 mm lateral to the peroneus tertius tendon. To avoid injury to the SPN, the safest placement of the anterolateral portal is 4 mm lateral to the peroneus tertius tendon. In another study, in 82% of specimens, the SPN ran between the lateral border of the talocrural joint and the peroneus tertius tendon at the talocrural joint level, where the anterolateral portal was placed. Therefore, the SPN was at high risk for injury with anterolateral portal placement.

Answer 20

The correct response is Option D. The most appropriate management of this patient with a soft-tissue defect and osteomyelitis is stabilization of the segment, debridement of the affected area, and coverage with a free latissimus dorsi pedicle flap. Application of an external fixator, radical sequestrectomy, placement of antibiotic beads, and autotransplantation of a free latissimus dorsi flap are performed initially; bone grafting of the tibial defect is performed secondarily. There is controversy regarding the precise advantages offered by free flaps when applied to infected bone. However, the basic principles for use of these flaps include skeletal stabilization, radical debridement of infected or devitalized tissues, and coverage with vascularized tissues. The free flap provides an abundance of vascularized tissue necessary to close large wounds left by aggressive debridement, and the muscle free flap provides pliability to fill the dead spaces. Total contact casting can be performed in patients with clean, slowly healing wounds of the distal lower extremity, but would only aggravate the fracture nonunion and osteomyelitis in this patient. Adequate debridement of only the soft-tissue scar and skin grafting over the wound will not result in a stable, healed site without infection. A soleus pedicle flap would not reliably cover this complex distal leg wound. In addition, the posterior compartment leg muscles and their vascular supply are frequently injured by high-energy injuries. Therefore, the soleus muscle is not likely to be reliable for transfer. A below-knee amputation would not be appropriate in a healthy patient with a sensate distal extremity in which the circulation is fully intact.

Answer 21

The correct response is Option E. The most appropriate classification for this injury is Gustilo Type IIIC. The Gustilo classification is the most widely accepted method for characterizing open fractures of the lower extremity. Injuries are divided into three grades. Type I open fractures involve soft-tissue lacerations smaller than 1 cm. Type II fractures include lacerations of 1 to 10 cm, with moderate soft-tissue damage. Type III fractures are greater than 10 cm and involve extensive soft-tissue damage. These injuries create difficulties in coverage of bone or fixation hardware. Gustilo Type III fractures are further subdivided into A, B, and C subtypes. Type IIIA fractures have sufficient soft tissue to provide for bony coverage. Type IIIB fractures involve periosteal stripping and extensive tissue damage, and local soft-tissue coverage is not possible. These typically result from high-energy mechanisms, such as high-velocity gunshot wounds or significant crush injuries. Gustilo Type IIIB fractures are the most common injuries for which plastic surgeons are consulted. Gustilo Type IIIC fractures include vascular injuries that require repair. The presence of a vascular injury significantly increases the probability of amputation.

Answer 22

The correct answer is option E. The soleus muscle flap is most appropriate for reconstruction in this patient. The soleus is a bipenniform muscle; its medial head originates from the posterior tibia, and the lateral head originates from the proximal fibula. It is located deep to the gastrocnemius in the superficial posterior compartment. Blood to the medial head is predominantly supplied by the popliteal and posterior tibial arteries and the lateral head is predominantly supplied by the peroneal artery. Depending on the size of the defect, a hemisoleus muscle flap can be used to preserve flexor function. Below-knee amputation is an option if salvage of the leg is not possible or if the extremity is insensate, particularly in older patients. An anterior tibialis muscle flap can be used for small defects. In this patient with an absent dorsalis pedis pulse and possible injury to the anterior tibial artery, this is not an optimum choice. For lower-extremity reconstruction, the gastrocnemius muscle flap is used for knee wounds and proximal tibial defects, the soleus for middle third defects, and free tissue transfer for distal third defects. The gastrocnemius muscle flap might not reach the defect in the middle third and therefore is not the best option. Free tissue transfer is often used for reconstruction of high-velocity injuries to avoid the use of muscle in the zone of injury. Free tissue transfer, however, is not the best option for this 53-year-old man because his history of cigarette smoking and absent pedal pulse suggest the possibility of peripheral vascular disease.

Answer 23

The correct response is Option E. The injury described is a Gustilo IIIB lower extremity wound complicated by infection. The sequence of reconstruction is often bony stabilization and debridement until bacterial balance. Bony deficits can be reconstructed in a variety of ways, including non-vascularized grafts, vascularized grafts (free of pedicle), and bone transport. Generally, for defects greater than 6 to 8 cm, vascularized bone grafting is indicated. Other indications for vascularized bone grafting are the presence of infection and prior failure of conventional (non-vascularized) grafting. Age of the patient is not a contraindication to reconstruction per se, as long as he or she is medically stable to undergo a prolonged operation. Gustilo Classification I: open fracture; clean; wound less than 1 cm II: open fracture; wound 1-10 cm IIIA: open fracture; >10cm extensive soft-tissue injury but adequate tissue for coverage IIIB: open fracture; extensive soft-tissue injury but inadequate tissue for coverage periosteum stripping IIIC: any of the above with a vascular (arterial) injury

Answer 24

The correct response is Option B. According to the results of several studies, the plantaris muscle has been shown to be absent in at least one lower extremity in approximately 10% to 15% of persons. This tendon can be used for grafting procedures. It provides a longer donor graft than the palmaris longus in the forearm; however, it is hidden on physical examination, making it more difficult to locate prior to surgery. Because the muscle may be absent in one or both lower extremities, ultrasonography can be helpful in determining its presence and location. Approximately 33% of patients have a plantaris muscle in only one lower extremity. Other studies have shown that absence of the plantaris muscle occurs with slightly greater frequency in women, and the plantaris muscle is more likely to be absent in the left lower extremity. Differences based on race and/or ethnicity have not been studied. In addition, absence of the plantaris muscle is unrelated to absence of the palmaris longus muscle; in other words, a person who is missing one or both plantaris muscles may in fact have one or both palmaris longus muscles.

Answer 25

The correct response is Option A. The indications for lower extremity replantation are limited. The best candidate for a lower extremity replantation would be a young patient who has had both legs amputated with a clean mechanism. Contraindications for lower extremity replantation include crush mechanism of injury, ischemia time over 8 hours, multiple-level injury, poor baseline health, and a patient of advanced age.

Answer 26

The correct response is Option E. The most appropriate answer is plantar flexion. The gastrocnemius muscle originates as two heads off the femur. The medial head comes off the medial condyle of the femur, just above the condyle and the lateral head comes off just above the lateral condyle. The muscle inserts onto the posterior calcaneus via the calcaneal tendon. This is the common tendon shared with the soleus muscle. Because of this fact, both heads can be harvested and the patient still maintains 75% of plantar flexion strength. The function of the gastrocnemius muscle is to plantar flex the foot and also flex the leg at the knee. Plantar flexion is the only biomechanical consequence listed above, although minimal. The blood supplies to the gastrocnemius muscle are from the sural branches of the popliteal artery and are independent. The medial head is the larger of the two and will have a larger arc of rotation. The innervation is via separate branches to each head off the tibial nerve.

Answer 27

The correct response is Option E. The reverse sural flap is a fasciocutaneous flap often used for ankle or heel wounds. The blood supply of the flap can be from a median superficial artery or the arterial plexus that travels with the sural nerve; the origin is a lower peroneal perforator located approximately 5 cm proximal to the lateral malleolus. The lateral sural artery would be the appropriate blood supply for perfusion of a pedicled lateral gastrocnemius flap. The gracilis flap blood supply derives from the medial circumflex artery. The descending genicular artery provides the blood supply of the medial femoral condyle flap. The medial plantar artery is the blood supply for the medial plantar artery flap.

Answer 28

Correct answer is option B. The pedicled gastrocnemius flap has been shown to be a reliable source of vascularized soft tissue for injuries of the distal thigh, knee, and proximal leg. The lateral or medial head may be harvested. Lateral gastrocnemius harvest risks damaging the common peroneal nerve, with an incidence of 7.7%. Medial gastrocnemius harvest, for obvious anatomical reasons, does not carry this risk. There are few data on the morbidity of donor sites, but those studies that have been done demonstrate no functional debility at a walking gait for less than 200 m. Patients do notice difficulty standing on their toes and have slowing with variable calcaneal gait when walking fast. Forty-two percent of patients could run, 22% had pain in the donor site at rest, and 20% had pain when walking more than 200 m. Seventy percent had pain and weakness in the operated leg when attempting to run. Range-of-motion deficit existed in the operated limb, with average loss of 27% flexion and 14% extension. The gracilis and sartorius muscles are not routinely used for pedicled reconstruction of the proximal tibia, nor would their harvest cause the symptoms of the patient described. The reversed sural artery flap is an adipofascial flap that could be used for this described defect; however, its dissection does not jeopardize the common peroneal nerve. The soleus muscle has better venous muscle pump function than the gastrocnemius, and edema, not nerve damage, is more common after use of the gastrocnemius. The limited data available suggest that the functional deficit with resulting limitation to ankle flexion is also more severe with soleus harvest.

Answer 29

The correct response is Option B. It is recommended that the proximal 4 to 8 cm of the fibula be preserved in order to prevent knee instability and to avoid injury to the peroneal nerve. In large resections, more fibula length is required and the fibular head is often useful in the reconstruction. The common peroneal nerve is formed by the lateral division of the sciatic nerve. The peroneal nerve wraps around the lateral surface of the biceps femoris tendon and fibular head and courses into the anterolateral portion of the leg. The common peroneal nerve trifurcates into the superficial peroneal nerve, the deep peroneal nerve, and the recurrent articular branch. The deep peroneal nerve innervates the anterior compartment muscles of the leg, and provides ankle dorsiflexion. Injury to the common or deep peroneal nerve can result in footdrop or weakened dorsiflexion. Given that this patient had a large resection, the footdrop is indicative of a peroneal nerve injury. Exploration is warranted. The tibial nerve is a branch of the sciatic nerve and runs in the popliteal fossa to pass below the arch of the soleus muscle. The sural nerve is a sensory nerve in the calf. Injury to the tibial or sural nerve would not cause a footdrop.

Answer 30

Correct Answer: C) Nerve transfer from the tibial nerve to the peroneal nerve branch to the anterior tibialis This patient has evidence of injury to the common peroneal nerve without recovery. Management options include exploration and grafting of the nerve, tendon transfers for dorsiflexion of the foot, and nerve transfers. Patients who are not surgical candidates may also be fitted for a footdrop orthosis. Since this patient has presented within a window of time that would allow for nerve transfer, he is a candidate for this procedure. Donor nerves for nerve transfer are typically derived from the tibial nerve and include the branches to the lateral head of the gastrocnemius, the flexor hallucis longus, and the flexor digitorum longus muscles. The recipient nerve is the peroneal nerve branch to the anterior tibialis. Nerves supplying the peroneus brevis, fibularis tertius, and extensor digitorum longus muscles arise from the common peroneal nerve and, therefore, would not be viable as donors. The branch supplying the rectus femoris muscle originates from the femoral nerve and is found high in the lateral thigh, making it unsuitable for transfer distal to the zone of injury. When comparing the outcomes of these procedures, consultation with the patient is critical. Nerve transfer results can offer inconsistent improvements in foot dorsiflexion, may result in weakness of toe flexion, and often require a nonsynergistic relearning of the motion, such as toe clenching with foot lift. In comparison, anterior transfer of the tibialis posterior tendon often does not restore normal gait and can lead to long-term complications, including hindfoot valgus deformity, arthritis, flatfoot deformity, and neuropathic arthropathy of the tarsal joints. Footdrop orthoses are usually unsatisfactory for patients, with noncompliance being common due to discomfort, hygiene, and mobility issues. Finally, nerve grafting is rarely successful, especially when the grafts exceed 6 cm in length, which is likely the case for this patient with a traumatic longitudinal traction injury. References: El-Taher M, Sallam A, Saleh M, Metwally A. Foot reanimation using double nerve transfer to the deep peroneal nerve: a novel technique for treatment of neurologic foot drop. Foot Ankle Int. 2021;42(8):1011-1021. doi:10.1177/1071100721997798 Emamhadi M, Naseri A, Aghaei I, Ashrafi M, Emamhadi R, Andalib S. Soleus nerve transfer to deep peroneal nerve for treatment of foot drop. J Clin Neurosci. 2020;78:159-163. doi:10.1016/j.jocn.2020.04.086 Giuffre JL, Bishop AT, Spinner RJ, Levy BA, Shin AY. Partial tibial nerve transfer to the tibialis anterior motor branch to treat peroneal nerve injury after knee trauma. Clin Orthop Relat Res. 2012;470(3):779-790. doi:10.1007/s11999-011-1924-9 Bao B, Wei H, Zhu H, Zheng X. Transfer of soleus muscular branch of tibial nerve to deep fibular nerve to repair foot drop after common peroneal nerve injury: a retrospective study. Front Neurol. 2022;13:745746. doi:10.3389/fneur.2022.745746 Giuseffi SA, Bishop AT, Shin AY, Dahm DL, Stuart MJ, Levy BA. Surgical treatment of peroneal nerve palsy after knee dislocation. Knee Surg Sports Traumatol Arthrosc. 2010;18(11):1583-1586. doi:10.1007/s00167-010-1204-3

Answer 31

**The correct answer is option B.** **Rationale:** Cancellous bone grafts possess greater osteogenic potential compared to cortical bone grafts due to their higher concentrations of osteoblasts and osteocytes, which directly contribute to new bone formation. In this case, where the priority is maximizing osteogenesis rather than immediate structural support, cancellous bone from the iliac crest is the optimal choice. Cortical grafts (options A and E) provide superior structural integrity but have slower resorption and lower osteogenic activity. Cortico-cancellous grafts (option C) offer a balance but may not match the pure osteogenic potential of cancellous bone alone. **References:** 1. Buck DW 2nd, Dumanian GA. Bone biology and physiology: part I. The fundamentals. Plast Reconstr Surg. 2012;129(6):1314-1320. doi:10.1097/PRS.0b013e31824eca94 2. Lee JC, Alford J, Willson T, Ozaki W. Improved success rate with corticocancellous block compared to cancellous-only trephine technique in alveolar bone grafting from the iliac crest. Plast Reconstr Surg. 2022;150(2):387e-395e. doi:10.1097/PRS.0000000000009352

Answer 32

The correct response is Option D. The patient is at high risk for fracture nonunion and osteomyelitis. The best next course of management is operative debridement ideally along with the treating orthopedist to make judgments about bone viability and debridement and the risks and benefits of hardware removal. Enzymatic wound debridement would not address the concerns about the deeper wound issues. The role for hyperbaric oxygen in the scenario presented is not well established. Bone cultures at the time of operative debridement should be obtained; but, percutaneous core needle cultures alone would not likely be adequate to obtain best healing. Free flap coverage may be required but is not indicated at this time.

Answer 33

The correct response is Option E. Gunshot wounds can create a range of nerve injuries from contusion to transection. Electrodiagnostic testing can be very helpful in later diagnosis and intraoperatively during nerve reconstruction but will not demonstrate changes in the nerve on the day of injury. EMG/nerve conduction testing will not demonstrate changes in findings until 2 to 6 weeks after injury. An accurate sensory and motor examination is the best initial step to identify abnormalities that can be tracked over time. The common peroneal nerve provides motor axons to the anterior and lateral compartment muscles. It also provides sensory axons to the dorsal foot, primarily via the terminal branches of the superficial peroneal nerve. Its only branch above the knee is to the lateral knee joint capsule. The saphenous nerve receives the terminal branches of the femoral nerve. It provides sensation to the medial-most plantar surface of the instep. The femoral nerve provides sensation to the thigh via cutaneous nerve branches as well as motor axons to the quadriceps muscle. Its terminal sensory fibers reach the foot via the saphenous nerve. The sural nerve is a terminal branch of the tibial nerve. It provides motor axons to the gastrocnemius muscle and sensory fibers to the lateral-most forefoot and midfoot dorsally and lateral-most midfoot and hindfoot plantarly. The tibial nerve provides sensation to the majority of the plantar surface of the foot via the medial and lateral plantar nerves. It also provides motor axons to the muscles of the deep posterior compartment, including the toe flexors. For the patient in this scenario, the tibial nerve is injured distal to the takeoff of the sural nerve.

Answer 34

The correct response is Option B. The sural artery flap is a cutaneous flap located on the posterior aspect of the lower leg. The flap is based on the arteries that accompany the lesser saphenous vein and sural nerve; the vein and nerve must be included in the flap. The axial pattern flap can cover defects around the knee and upper third of the leg. The reverse flow flap was first introduced by Masquelet in 1992 and is a workhorse flap for pedicle reconstruction of the lower third defects in the leg. The anterior tibial, posterior tibial, popliteal, and peroneal veins do not contribute to the vascular anatomy of this flap.

Answer 35

The correct response is Option A. The common peroneal nerve forms as the sciatic nerve bifurcates at the apex of the popliteal fossa. It then follows the medial border of the biceps femoris muscle and tendon. The nerve then passes over the posterior aspect of the fibular head and winds around the neck of the fibula. The common peroneal then divides into the deep and superficial peroneal nerve branches. The deep branch supplies the anterior muscles of the leg, the dorsum of the foot, and the skin of the first web space. The superficial branch supplies the peroneus longus and brevis muscles and the skin on the distal third of the lower leg and dorsum of the foot. Because of its relatively superficial position, the common peroneal nerve is the most commonly injured nerve of the lower extremity. Transection of the common peroneal nerve results in paralysis of all muscles in the anterior and lateral compartments of the leg (dorsiflexors and ankle evertors). This pattern of injury results in the classic picture of a foot drop. The distribution of sensory loss would include the anterolateral leg and dorsum of the foot. Sensation of the medial foot is from the saphenous nerve and branches of the medial plantar nerve. Lateral foot sensation is provided by the sural nerve. Sensation of the plantar aspect of the foot is from the terminal branches of the tibial nerve (medial and lateral plantar nerves). All of the muscles of plantar flexion of the ankle and toes (i.e. gastrocnemius, soleus, plantaris, and tibialis posterior, flexor hallucis longus, flexor digitorum longus, and the intrinsic plantar foot muscles) are innervated by the tibial nerve. Reference(s) 1. Anderson JC. Common fibular nerve compression: anatomy, symptoms, clinical evaluation, and surgical decompression. Clin Podiatr Med Surg. 2016 Apr;33(2):283-291. 2. Kleiber GM, Parikh RP. Comprehensive lower extremity anatomy. In: Song D, e. Volume 4: Lower Extremity, Trunk, and Burns. Philadelphia, PA: Elsevier Churchill Livingstone; 2017:1-52. Plastic Surgery; Neligan PC, ed.

Answer 36

The correct answer is option E. The key determinant for the reconstructive choice is the wound bed. A wound with exposed bone, particularly in the distal third of the leg, lacks the vascularity required to support a skin graft, which relies on imbibition and inosculation from a well-vascularized bed. Therefore, a skin graft (option A) would fail. Primary closure (option B) is not feasible due to the size of the defect and tissue loss. Local flaps (option C) and pedicled muscle flaps like the gastrocnemius (option D) are reliable for proximal and middle third leg defects but do not reliably reach the distal third due to their limited arc of rotation. A free tissue transfer (free flap) provides a distant, well-vascularized tissue source that can reliably cover exposed bone in this challenging location. References: Azoury SC, Kovach SJ, Levin LS. Reconstruction options for lower extremity traumatic wounds. J Am Acad Orthop Surg. 2022;30(16):735-746. doi:10.5435/JAAOS-D-21-01081 Fleming ME, O'Daniel A, Bharmal H, Valerio I. Application of the orthoplastic reconstructive ladder to preserve lower extremity amputation length. Ann Plast Surg. 2014;73(2):183-189. doi:10.1097/SAP.0b013e3182a638d8

Answer 37

The correct response is Option B. The most important next step in establishing a diagnosis in this patient is an excisional biopsy. The clinical appearance and duration of the chronic wound is highly suggestive of a Marjolin ulcer in the setting of a chronic venous stasis ulcer. Marjolin ulcers are defined as malignant generation in the presence of a burn wound or other chronic inflammatory conditions. The most common etiology is a burn wound; however, malignancies have been found in chronic wounds secondary to pressure ulceration, trauma, venous stasis, and others. The most common pathologic diagnosis is well-differentiated squamous cell carcinoma (SCC), but basal cell carcinoma and various other sarcomas have been reported in the literature. Marjolin ulcers are thought to be aggressive forms of SCC with metastatic potential related to tumor grade. The incidence of metastasis is 10% for Grade 1 lesions, 59% for Grade 2, and 86% for Grade 3. Diagnosis is based on clinical appearance, history, and most importantly biopsy. Patients should also receive a thorough regional lymph node exam, CT scan or MRI, and routine laboratory analysis. Sentinal lymph node biopsy may be indicated. Treatment is generally wide excision of the chronic wound and rapid coverage with skin grafts or tissue flaps. Depending on tumor characteristics, adjuvant radiation therapy may be recommended. Angiography will evaluate the arterial flow of the extremity and may be important in planning coverage of the wound, but it is not required to rule out a malignancy. MRI, CT scan, and x-ray studies can also be helpful as adjunctive diagnostic techniques to evaluate the extent of the tumor and presence of metastasis, but they are not used for diagnosis alone.

Answer 38

The correct response is Option B. In recent studies by Wong, et al, and Rozen, et al, attempts have been made to clarify the vascular perforator anatomy of the anterolateral thigh flap. It has been noted that sizeable vascular perforators may arise from the ascending, transverse, or descending branch of the lateral circumflex femoral artery. The most common supply, however, comes from the descending branch, followed by the transverse and ascending branches. The descending branch is dominant in about 85% of cases. A variable oblique branch, which can occasionally be the primary supply, has also been noted. This branch, when it exists, is usually the primary supply of the flap in 15% of cases. It typically is an offshoot of the descending or transverse branch.

Answer 39

The correct response is Option E. The injury described is a Gustilo IIIB lower extremity wound complicated by infection. The sequence of reconstruction is often bony stabilization and debridement until bacterial balance. Bony deficits can be reconstructed in a variety of ways, including non-vascularized grafts, vascularized grafts (free of pedicle), and bone transport. Generally, for defects greater than 6 to 8 cm, vascularized bone grafting is indicated. Other indications for vascularized bone grafting are the presence of infection and prior failure of conventional (non-vascularized) grafting. Age of the patient is not a contraindication to reconstruction per se, as long as he or she is medically stable to undergo a prolonged operation. Gustilo Classification I: open fracture; clean; wound less than 1 cm II: open fracture; wound greater than 1 cm IIIA: open fracture; extensive soft-tissue injury but adequate tissue for coverage IIIB: open fracture; extensive soft-tissue injury but inadequate tissue for coverage IIIC: any of the above with a vascular (arterial) injury

Answer 40

The correct response is Option B. Perforator flap reconstruction, whether free or pedicled, has become increasingly popular over the past decade. Perforator flap use allows for the creation of an axial pattern flap without the sacrifice of a major artery and can often be done for areas once considered to require free flaps for coverage. Prior transfer of a medial gastrocnemius flap might disrupt perforators from the posterior tibial artery to the medial leg skin, but would not have disturbed anterior tibial artery perforators through the skin of the anterolateral leg. Skin grafting, whether split- or full-thickness, would not be successful on fractured bone without periosteum, regardless of the type of dressing used. The lateral gastrocnemius muscle is smaller and cannot reach as far as the medial gastrocnemius. It would not be able to reach the mid-shaft tibia defect shown in this patient. The descending medial genicular artery is the pedicle of the medial femoral condyle flap. It is normally used as a bone graft donor, although an overlying skin paddle can be harvested with it. When used in a pedicled fashion, it can be transposed proximally onto the thigh, but not distally onto the leg.

Answer 41

The correct correct answer option B. Harvesting muscle may result in increased function loss compared to fasciocutaneous flaps depending on the donor site. Muscle flaps are often more difficult to monitor clinically than fasciocutaneous flaps, as capillary refill cannot be assessed, and muscle color may be difficult to assess if covered with a skin graft and dressing. Raising a fasciocutaneous flap at a secondary procedure is often easier due to the more obvious plane below the fascia, as well as ingrowth of vessels into the periphery of the flap. However, fasciocutaneous flap dissection may be more difficult and time-consuming, although does improve with surgical experience. Shokrollahi 2017

Answer 42

The first dorsal metatarsal artery (FDMA), arising from the dorsalis pedis artery, is the most common primary arterial blood supply to the great toe flap, which is used in toe-to-thumb transfer. Although the vascular anatomy that supplies the great toe flap is somewhat variable, the FDMA typically arises from the dorsalis pedis artery and travels in a relatively dorsal plane. It may travel dorsal or plantar to the interosseous muscle or through the muscle itself. The FDMA is less likely to arise from the communicating branch between the dorsalis pedis and plantar arteries or from the plantar arch. The second dorsal metatarsal artery does not contribute to the great toe flap.

Answer 43

The correct answer is option a. Heel wounds are best reconstructed with glabrous tissue if possible. The medial plantar artery is the vascular supply to the medial plantar flap. This flap provides durable glabrous offering the best reconstruction to replace “like tissue with like tissue” Other options for heel reconstruction typically involve free tissue transfer. Some people debate if muscle flaps or fasciocutaneous flaps are better but both have successfully be used. The medial femoral circumflex supplies the gracilis flap and the radial artery supplies the radial forearm flap. Peroneal perforators supply the reverse sural flap. Depending on the size and exact location all of these flaps are potential options but likely secondary choices if a medial plantar flap is available. Dorsalis pedis flaps have a high donor site morbidity and would not reach the heel.

Answer 44

The correct response is Option C. In a young patient who desires limb preservation after sarcoma resection, a contralateral vascularized fibula free flap with bone allograft (Capanna technique) is the most appropriate option for a large intercalary segmental defect. This involves placing the fibula flap within an allograft construct and bridging both osteotomy sites. There are advantages to using the allograft with the fibula flap, as a fibula flap alone may have difficulty with weight-bearing and potential fracture. In select cases a double barrel configuration can be used; however, in this patient the defect is too large. An ipsilateral pedicled flap would have difficulty reaching this large defect and would still have issues with fractures from weight-bearing. Ilizarov bone transportation can be performed for smaller defects (4 to 6 cm), but not in a defect this large. Finally, bone allograft alone is an option; however, this has a high rate of nonunion (34% versus 8 to 10%).

Answer 45

The correct response is Option C. The tibial nerve bifurcates distally into the medial and lateral plantar nerves, and it is these two nerves that are impinged in the tarsal tunnel. The flexor digitorum superficialis is in the forearm, not the leg. The flexor digitorum brevis flexes both the proximal and the middle phalanges of the toes and is innervated by the medial plantar nerve. Other intrinsic toe flexors are flexor hallucis brevis (medial plantar nerve), flexor digiti minimi brevis (lateral plantar nerve), and the interossei (lateral plantar nerve) and lumbricals (medial and lateral plantar nerves). In the most severe situation, a patient with tarsal tunnel syndrome may have €œclaw toes. € Quadratus plantae is a flexor of the lateral four toes through the flexor digitorum longus but is innervated by the lateral plantar nerve. While flexor digitorum longus is a toe flexor and is also innervated by the tibial nerve, this nerve would not be involved at the tarsal tunnel.

Answer 46

The correct answer is option D. This Gustilo IIIB wound is best covered with a free muscle flap. The latissimus muscle flap is an effective and frequently used flap for large wounds. This flap also has the advantage of large vessels and a long pedicle length. Dressing changes followed by a skin graft will not provide durable coverage over the tibia, is not appropriate in a healthy teenager who is not at surgical risk, and the time delay to coverage may predispose the patient to the development of osteomyelitis. A neuroadipofascial flap based on the vessels accompanying the sural nerve would be a poor choice, as this would be harvested from the zone of injury. The soleus flap is traditionally used for middle third defects of the leg and also is within the zone of injury. This is a salvageable extremity in a young teenager, which makes amputation inappropriate.

Answer 47

The correct response is Option B. The first dorsal metatarsal artery (FDMA), arising from the dorsalis pedis artery, is the most common primary arterial blood supply to the great toe flap, which is used in toe-to-thumb transfer. Although the vascular anatomy that supplies the great toe flap is somewhat variable, the FDMA typically arises from the dorsalis pedis artery and travels in a relatively dorsal plane. It may travel dorsal or plantar to the interosseous muscle or through the muscle itself. The FDMA is less likely to arise from the communicating branch between the dorsalis pedis and plantar arteries or from the plantar arch. The second dorsal metatarsal artery does not contribute to the great toe flap.

Answer 48

The correct response is Option B. Heel reconstruction is a difficult surgical problem with limited local options, relatively poor vascularity in the region, and weight-bearing requirements. Flap options include a variety of local flaps including transposition or rotation flaps, fasciocutaneous flaps (e.g., medial plantar); local muscle flaps (e.g., abductor hallucis, flexor digitorum brevis, and abductor digiti minimi); reversed fasciocutaneous flaps (e.g., sural); and free flaps. Although innervated (and therefore potentially sensate) free flaps can be performed, these are less predictable than local options. From the above answer choices, the best option is a local flap based on the medial plantar artery, which had sensation from the medial plantar nerve, a branch of a division of the posterior tibial nerve. Another advantage of the medial plantar artery flap is that it covers the heel with glabrous skin, which may better be able to withstand weight-bearing. The other options are not correctly matched with flaps and nerves. Correct pairings of flap and cutaneous innervation are: Anterior lateral thigh flap - lateral femoral cutaneous nerve Ulnar forearm flap - medial antebrachial cutaneous nerve Radial forearm flap - lateral antebrachial cutaneous nerve Reverse sural artery flap - sural nerve

Answer 49

The correct response is Option E. The surgical step required as part of the “delay” procedure in a distally based sural flap is division of the proximal lesser saphenous vein. The distally based sural flap is a neurofasciocutaneous flap used to reconstruct ankle, heel, and foot defects. The classically described and possibly most important arterial supply to the distally based sural flap is provided by septocutaneous perforators arising from the peroneal artery. The most distal of these is located 4 to 7 cm proximal to the lateral malleolus. However, there are at least three other sources described: fasciocutaneous perforators from the posterior tibial artery, venocutaneous perforators from the lesser saphenous vein, and neurocutaneous perforators from the sural nerve. The skin and fascia of the flap are drained primarily by the lesser saphenous vein. The lesser saphenous vein contains numerous valves that prevent retrograde blood flow. There are, however, one or more smaller collateral veins that run parallel to the lesser saphenous vein. These veins have anastomotic connections to the lesser saphenous vein, which can allow blood to bypass the valves of the lesser saphenous vein and flow in a retrograde fashion. In attempts to redirect blood flow and decrease the risk of flap necrosis and other complications, several authors have described sural flap delay procedures. Two distinct delay procedures have been described. In one, the flap is first elevated without completely incising the proximal edge of the skin island. A powder-free glove is then placed between the elevated fascia and the gastrocnemius muscle, and the skin is closed. Two weeks later, the flap is completely elevated and transferred into the defect site. This procedure has the goal of redirecting blood flow in a longitudinal direction before complete elevation of the flap. In the other technique, the flap is raised in its entirety and then sutured back into its donor site. The flap is then transferred into its recipient site as a second procedure. This technique allows the flap to become viable on its distal vascular pedicle before causing the additional trauma of transferring the flap, which can potentially compromise that pedicle. Division of the greater saphenous vein is not indicated because it is not in the vicinity of the flap. Similarly, division of the perforator 5 cm proximal to the lateral malleolus is not appropriate because this is the major pedicle supplying the flap.

Answer 50

The correct response is Option B. The deep peroneal nerve emerges from the leg anterior compartment musculature, from beneath the extensor retinaculum of the ankle. The nerve gives off a motor branch to the extensor digitorum brevis, and then terminates into the first web space of the foot, after running beneath the tendon of the extensor hallucis brevis. Entrapment of this nerve, as it exits the extensor retinaculum of the ankle, can manifest itself as pain, weakness, or numbness or tingling over the dorsum of the foot. The saphenous nerve innervates the cutaneous region over the anterior-medial aspect of the distal leg and ankle. The medial sural nerve innervates the cutaneous region over the posterior lateral aspect of the lower leg. The tibial nerve innervates the plantar surface of the foot. It divides into the medial and lateral plantar nerve over the plantar aspect of the foot. The medial and lateral plantar nerves innervate the cutaneous aspect of the plantar foot and the intrinsic musculature of the foot.

Answer 51

Correct answer is option C. The most appropriate management is coverage of the defect with a fasciocutaneous flap. This flap is ideal for reconstruction of lower extremity wounds in patients with severe illness or multiple trauma, or in patients with small wounds that cannot be covered with a skin graft alone. The fasciocutaneous flap can be based either proximally or distally on various septocutaneous perforators, including those of the medial leg (which lie approximately 3 cm posterior to the tibia), the posterolateral septum, and the anterolateral leg. Skin grafting should not be performed over bone that is exposed and lacks periosteum. Some surgeons have recently described a technique for grafting over exposed bone, in which holes are drilled into the bone to allow for granulation and grafting is then performed. However, this process is not the best option in an elderly patient with multiple medical problems. The gastrocnemius flap is appropriate for defects of the upper and sometimes middle third of the leg, but lacks the adequate reach for defects of the distal leg. Cross-leg flaps are rarely used now because of the availability of free tissue transfer. This flap is more appropriate in children than elderly patients, in whom stiffness is a factor. Free tissue transfer is not an option in a patient who has had serious medical conditions, including stroke, myocardial infarction, and pulmonary disease.

Answer 52

The correct response is Option B. Compared with a conventional nonvascularized autograft, a vascularized fibula graft has increased osteocyte viability. In one study, osteocyte counts in the cortex of vascularized grafts were 89% of those observed in normal control subjects. There were substantially fewer surviving osteocytes in conventional grafts. Nonvascularized bone autograft incorporation occurs by creeping substitution, which involves gradual vascular ingrowth, resorption, and replacement of necrotic bone. The revascularization process that occurs causes significant mechanical weakening due to bone resorption at six to 12 months. Vascularized bone grafts allow living bone tissue to be transplanted to an adjacent or remote location. They have been used in segmental bone defects larger than 6 cm due to tumor, trauma, osteomyelitis, or infected nonunion. Other indications include avascular necrosis of bone, composite tissue loss requiring complex reconstruction, and longitudinal growth with physeal transfer. The transfer of vascularized bone grafts increases cell survival and as a result the process of bone graft incorporation by creeping substitution is obviated. Significant osteopenia is not seen and bone mass is maintained after transfer. The result is improved strength, healing, and stress response. Cell survival results in less remodeling during revascularization.

Answer 53

The correct response is Option E. The reverse-flow sural flap has become one of the more dependable solutions in distal third leg wound and heel reconstruction. Survival of the flap depends on intact flow into the superficial sural arterial network via perforators from the peroneal system. The largest perforator arises roughly 5 cm cephalad to the lateral malleolus and typically marks the lowest pivot point for the flap. None of the remaining choices would provide adequate perfusion for this flap.

Answer 54

The correct response is Option B. Venous insufficiency is staged using the CEAP (clinical, etiologic, anatomical, and pathophysiologic) classification. The patient presented in this scenario meets the criteria for C6 (Clinical 6) criteria with the presence of an active ulcer. Compression and keeping the wound clean are the initial, primary, and mainstay therapies for healing venous ulcers. The only option listed that provides compression and wound care is to clean the wound, elevate, and apply serial compression dressings (Unna boot). After a trial of compression and wound bed optimization, closure can be considered. The literature does not provide conclusive evidence that skin grafting is a superior or desired closure. There are studies that demonstrate the superiority of Apligraf in achieving wound closure. If the perforators are found to be the source of the issue, ligation may reduce the recurrence of ulcers in the area but studies comparing ligation and wound care do not show earlier closure of ulcers present. Hyperbaric oxygen therapy (HBOT) is not indicated in this situation.

Answer 55

The correct response is Option C. Lower extremity osteomyelitis following trauma is a challenging problem with high complication rates. The key to success is adequate debridement of both bone and soft tissue followed by coverage with vascularized tissue. The patient described had debridement of soft tissue but not bone. The bone is a persistent source of infection and the scarred fibrotic soft tissue is poorly vascularized, thus crippling the immune response. Without adequate bone debridement, early recurrence is likely. Muscle flaps fill the resultant defect, enhance blood flow, and improve immunologic defense against microorganisms. The scapula flap can easily provide skin paddles of 10 Ã— 15 cm; therefore, closure under tension would not be a problem. A bone biopsy is helpful in identifying the bacteria and choosing the best antibiotic, but it does not substitute for bone debridement. Though muscle flaps are generally more effective in the treatment of osteomyelitis than cutaneous flaps, many authors have demonstrated that well-vascularized skin flaps can be successful. Many authors have demonstrated success with one €‘stage reconstructions for traumatic osteomyelitis. Again, success is dependent upon performing adequate bone and soft-tissue debridement followed by a well €‘vascularized flap.

Answer 56

The correct response is Option E. The primary blood supply to the medial plantar flap is the medial plantar artery, a terminal branch of the posterior tibial artery. The dorsalis pedis is the continuation of the anterior tibial artery and does not contribute to this flap. The peroneal artery is a proximal branch of the posterior tibial artery and descends in the deep posterior compartment posterior to the tibialis posterior and anterior to the flexor hallucis longus; it does not contribute to this flap. The arcuate artery is the terminal branch of the anterior tibial artery. The plantar arch runs on the plantar aspect of the foot at the level of the metatarsals; it is formed from a confluence of the lateral plantar artery and the deep plantar artery from the dorsalis pedis.

Answer 57

The correct answer is option E. The anterolateral thigh (ALT) flap has proven to be one of the most versatile free tissue transfers in reconstructive surgery. Based on perforators from the descending branch of the lateral circumflex femoral artery that traverse the vastus lateralis (VL) (80%) or the septum between the rectus femoris and VL (18-20%), this flap can be fashioned as large as 10 cm wide by 25 cm long. Occasionally, no large perforator will be identified during dissection; in this circumstance, the flap may be carried on multiple perforators along with the vastus lateralis muscle. Branches of the lateral circumflex femoral artery also supply the sartorius (partial, as the supply is segmental), rectus femoris (descending branch), and tensor fascia lata (ascending branch). Vascular supply to the gluteus maximus arises from the superior and inferior gluteal arteries.

Answer 58

The correct response is Option D. For the noninfected, nonischemic, neuropathic diabetic foot ulcer, pressure reduction through offloading measures is of critical importance. The International Working Group on the Diabetic Foot strongly recommends the use of a non-removable knee-high offloading device as first line treatment. This is supported by high-level quality evidence and multiple studies. These non-removable knee-high offloading devices include the use of total contact casts and non-removable knee-high walker devices. Removable offloading devices, such as custom molded and other therapeutic shoe inserts, as well as multiple therapeutic shoe designs, have consistently been shown to be less effective in healing chronic wounds than non-removable devices. This may be largely because of patient non-compliance. Surgical interventions that may decrease plantar pressures, such as Achilles tendon lengthening, metatarsal head resection, and metatarsal-phalangeal joint arthroplasty, may be of less utility and should only be considered when nonsurgical methods have failed. Hyperbaric oxygen therapy may play a significant role in Wagner grade III (bone involvement) or greater diabetic foot wounds in terms of increased healing and decreased amputation rate; however, evidence is lacking to suggest its routine use in soft-tissue-only diabetic foot ulcers.

Answer 59

The correct response is Option E. According to the results of an animal in vitro study, low-pressure pulse lavage with 1% surgical soap resulted in a more significant clearing of bone-adherent bacteria than other solutions. Low-pressure lavage was defined as 14 psi of pressure with 550 pulsations per minute; the solutions were evaluated in 1% and 10% concentrations. Osteoclast and osteoblast function was also shown to be preserved more significantly with use of the 1% soap or detergent solution. In contrast, the other solutions studied were shown to have a deleterious effect on osteoclast and osteoblast function. Low-pressure lavage with chlorhexidine or povidone-iodine was associated with the greatest decrease in osteoblast and osteoclast function. The antibacterial mechanism of soap is thought to act through its micelle function. The hydrophilic ends of the soap micelle surround the bacteria, interfering with its potential for adherence to bone. High-pressure lavage should not be used because it results in a significant depth or zone of bony injury.

Answer 60

Correct answer is option D. The most appropriate management of this patient with a soft-tissue defect and osteomyelitis is stabilization of the segment, debridement of the affected area, and coverage with a free latissimus dorsi pedicle flap. Application of an external fixator, radical sequestrectomy, placement of antibiotic beads, and autotransplantation of a free latissimus dorsi flap are performed initially; bone grafting of the tibial defect is performed secondarily. There is controversy regarding the precise advantages offered by free flaps when applied to infected bone. However, the basic principles for use of these flaps include skeletal stabilization, radical debridement of infected or devitalized tissues, and coverage with vascularized tissues. The free flap provides an abundance of vascularized tissue necessary to close large wounds left by aggressive debridement, and the muscle free flap provides pliability to fill the dead spaces. Total contact casting can be performed in patients with clean, slowly healing wounds of the distal lower extremity, but would only aggravate the fracture nonunion and osteomyelitis in this patient. Adequate debridement of only the soft-tissue scar and skin grafting over the wound will not result in a stable, healed site without infection. A soleus pedicle flap would not reliably cover this complex distal leg wound. In addition, the posterior compartment leg muscles and their vascular supply are frequently injured by high-energy injuries. Therefore, the soleus muscle is not likely to be reliable for transfer. A below-knee amputation would not be appropriate in a healthy patient with a sensate distal extremity in which the circulation is fully intact.

Answer 61

The correct response is Option E. Fundamentals of nerve repair include coaptation in a tension-free manner. If there is any tension, nerve grafts or conduits are indicated. In this clinical scenario, there is a large nerve gap that precludes tension-free primary coaptation, even with extensive proximal and distal mobilization. Therefore, a nerve graft is indicated. Common choices include sural, lateral, or medial antebrachial cutaneous. For the size and length of the defect and the fact that multiple cable grafts would be needed, the sural is the most appropriate choice. Nerve conduits such as PGA tubes and processed human allograft conduits serve as scaffolds to promote nerve regeneration, although these are typically used for gaps less than 3 cm. Given the distance involved, a sural nerve graft using a grouped fascicular or epineurial repair is the most appropriate choice, although a gap this large is almost certain to leave permanent deficits. Appropriate levels of expectation must be set with the patient.

Answer 62

**The correct answer is option C.** **Rationale:** The combination of a structural allograft with an intramedullary vascularized fibula flap is a established technique for large segmental bone defects. This approach provides immediate structural support from the allograft while the vascularized fibula promotes revascularization and incorporation of the allograft through its blood supply, leading to significantly improved outcomes in pediatric long bone reconstruction. A structural allograft alone (option A) lacks the biological component for reliable incorporation and has a higher failure rate. A free fibula flap alone (option B) may not provide sufficient immediate structural support for a large femoral defect. Bone morphogenetic protein (option D) requires viable cells and a blood supply to function, which a nonvascularized allograft lacks. An external bone stimulator (option E) is used for delayed unions in native bone healing but does not facilitate the revascularization of a large allograft. **References:** 1. Houdek MT, Wagner ER, Stans AA, et al. What is the outcome of allograft and intramedullary free fibula in pediatric and adolescent patients with bone tumors? Clin Orthop Relat Res. 2016;474(3):660-668. doi:10.1007/s11999-015-4204-2 2. Bakri K, Stans AA, Mardini S, Moran SL. Combined allograft and intramedullary vascularized fibula transfer for lower-limb reconstruction. Semin Plast Surg. 2008;22(3):234-241. doi:10.1055/s-2008-1081406 3. Momeni A, Weber KL, Kovach SJ. A modification of an established method of intercalary extremity bone defect reconstruction. Ann Plast Surg. 2018;81(2):240-243. doi:10.1097/SAP.0000000000001554

Answer 63

Correct answer is option a.

Answer 64

The correct answer is option C. Histopathologic confirmation of osteomyelitis via bone biopsy has long been the gold standard for establishing this diagnosis. However, because of the invasive nature of the procedure required for accurate bone biopsy, multiple other diagnostic modalities are commonly used. A recent systematic review confirmed that these alternative diagnostic methods, including clinical diagnosis and imaging modalities, such as bone scanning, MRI, CT scanning, and x-ray studies, were not as reliable as histology on bone biopsy. It is important to note that bone biopsy specimens should be sent for histopathology and not culture. In fact, it was shown that microbiologic examination of cultures of bone biopsy specimens displays high sensitivity but low specificity, likely reflecting contamination, in comparison with histopathologic examination. Chicco M, Singh P, Beitverda Y, Williams G, Hirji H, Rao GG. Diagnosing pelvic osteomyelitis in patients with pressure ulcers: a systematic review comparing bone histology with alternative diagnostic modalities. J Bone Jt Infect. 2020;6(1):21-32. doi:10.5194/jbji-6-21-2020 Han H, Lewis VL Jr, Wiedrich TA, Patel PK. The value of Jamshidi core needle bone biopsy in predicting postoperative osteomyelitis in grade IV pressure ulcer patients. Plast Reconstr Surg. 2002;110(1):118-122. doi:10.1097/00006534-200207000-00021

Answer 65

The correct response is Option B. Contrast-induced nephropathy (CIN) is a significant problem in patients undergoing procedures that require contrast administration. The mechanism is believed to be an ischemic injury to the renal medulla. It is the third most common cause of hospital-acquired renal failure. Independent of renal failure, the development of even mild CIN is associated with increased rates of morbidity and mortality. The major risk factor for developing CIN is pre-existing renal dysfunction. This is particularly associated with patients with diabetes and those who have a creatinine clearance less than 60. The best method of prevention is appropriate risk stratification, intravenous hydration with normal saline and withholding of nephrotoxic medications. Intravenous fluid hydration with normal saline is the mainstay of practice in the prevention of CIN. It is low-risk, carries few side effects, and is cost-effective. Randomized trials have found intravenous hydration with normal saline to be consistently effective. The administration of intravenous fluids increases intravascular volume, promotes diuresis, diminishes the overall intravascular contrast load and supports vasodilation. Although intravenous administration of sodium bicarbonate has also gained popularity in the prevention of CIN, recent publications have demonstrated mixed results. The use of N-acetylcysteine, statin drugs and ascorbic acid are not recommended for the prevention of CIN.

Answer 66

The correct response is Option A. The most appropriate management of this patient’s bone defect is a free fibula surrounding flap. Management typically depends on the volume of the bony defect along with soft-tissue stability and vascularity. If the tissue is unstable and poorly vascularized, a regional flap or free flap is required. For most bone defects smaller than 6 cm, traditional tricortical iliac crest bone grafts can be placed beneath the muscle flap. In patients with larger defects, a vascularized bone flap, such as the free fibula flap, is required. Vascularized bone also minimizes the risk for nonunion. However, weight-bearing ambulation should not occur for many months after flap coverage to allow for healing of bone without infection. Other sources of free vascularized bone include the iliac crest and scapula. However, the iliac crest has both inadequate length and excessive curvature, and the scapula has inadequate length and lacks the tubular depth and width of the fibula. Papineau grafts are cancellous grafts that are used to fill the bone defect but are packed flush with the skin. These grafts are seldom used clinically and are appropriate only for defects smaller than 6 cm. Tibiofibular synostosis is not a reasonable option in a patient with osteomyelitis of the distal tibia who has compromised stability and vascularity of the soft tissue. The Ilizarov technique for bone transport is less optimal in a patient who requires a long bone segment and has soft tissue of poor quality.

Answer 67

The correct response is Option C. Although various techniques have been used successfully to reconstruct large bony defects of the lower extremity, the most reliable technique for such a large bone gap is the fibular free flap reconstruction. The Ilizarov osteodistraction technique can be used for large defects, but would necessitate a very long period of immobilization and fixation. Neither autogenous nor cadaveric bone graft would be as reliable as vascularized bone.

Answer 68

The correct response for Item 1. is Option B and for Item 2. is Option C. The fibula osseocutaneous flap is a composite bone, fascia, and skin flap supplied by the peroneal artery. The proximally based soleus muscle flap is supplied by branches of the popliteal artery. A distally based soleus muscle flap is supplied by branches of the posterior tibial artery. None of the mentioned flaps is supplied by the anterior tibial artery.

Answer 69

The correct response is Option B. Composite tissue reconstruction after tumor ablation is a significant challenge to the plastic surgeon. Generally, bony defects greater than 6 cm require vascularized bone for reconstruction. For large defects, the optimum choice of bone is the vascularized fibula. The fibula also has a reliable blood supply from the peroneal artery and can be harvested with a cutaneous skin paddle. The fibula free flap is the most appropriate technique. Reconstruction with free flaps can be successfully performed in a patient with a smoking history and, in fact, is often the optimal method of reconstruction in smokers. The use of allograft cadaver bone is not indicated, especially in a patient with a history of smoking. For defects of the size shown in the photograph, the locking fixation plate would not give adequate long-term support. A local bone flap is also not a viable option.

Answer 70

The correct response is Option D. The Gustilo classification of open fractures is based on the severity of soft-tissue injury and the presence or absence of concurrent vascular injury. A higher grade implies a more severe injury, and correlates with a greater incidence of complications and need for amputation. The patient in this item has a wound greater than 10 cm and a heavily comminuted tibia fracture. There is no mention of vascular injury. He has a Gustilo type IIIB injury. The Gustilo grading scale: TypeFindings IClean wound bed, simple/minimally comminuted bone injury, wound \< 1 cm IIWound contaminated, moderate comminution of bone, wound \> 1 cm IIIAWound highly contaminated, severe comminution, wound 1 to 10 cm IIIBWound highly contaminated, severe comminution, wound \> 10 cm IIICMajor vascular injury requiring repair for limb salvage

Answer 71

The correct response is Option C. The soleus muscle is a broad, powerful muscle of the posterior calf which, along with the gastrocnemius muscle, forms the triceps surae. The soleus takes its origin from the upper third of the fibula and medial border of the tibia and inserts into the calcaneus with the gastrocnemius muscle by way of the Achilles tendon. The blood supply of the soleus muscle is from the peroneal artery proximally and the posterior tibial artery distally. This soleus muscle flap is used as a pedicle muscle flap for coverage of defects of the middle third of the lower leg.

Answer 72

The correct answer is option B. best predictor of long term patency is vein quality

Answer 73

The correct response is Option A. The Gustilo classification describes open fractures of the tibia by the severity of the soft tissue injury overlying the fracture. In patients with IIIB injuries, there is extensive soft-tissue loss and periosteal stripping, but no vascular compromise requiring repair. Gustilo classification: Type I: The wound is less than 1 cm long. There is little soft-tissue damage and no sign of crush injury. There is no or minimal comminution of the fracture. Type II: The laceration is more than 1 cm long but there is no extensive soft tissue damage, flap, or avulsion. There is slight to moderate crushing injury, moderate comminution of the fracture. Type III: Extensive damage to the soft tissues, including muscle, skin, and neurovascular structures, and a high degree of contamination. Type IIIA: Soft tissue coverage of the bone is adequate. Type IIIB: Extensive injury to or loss of soft tissue, with periosteal stripping and exposure of bone, massive contamination, and severe comminution of the fracture from high-velocity trauma Type IIIC: Any open fracture with a vascular injury requiring repair. Free tissue transfer will bring healthy, nontraumatized tissue into the area to cover the exposed broken bone. Multiple recent studies have shown equivalence of muscle versus skin/fat/fascia flaps for coverage of the open fracture even in patients with osteomyelitis. Negative pressure wound therapy has proven to be an excellent adjunct in the management of patients with these injuries. Between washouts, negative pressure devices can help decrease edema and isolate the wound and bone from the outside world. In a patient with a IIIB injury, there is insufficient tissue available to cover the wound. Therefore, secondary intention would not close the wound. Split-thickness skin grafting provides an epithelial barrier to help seal off a wound from outside contamination. Grafts require a viable wound bed to survive. There must be a pliable bed to help grafts resist minor trauma in the future. With the periosteal stripping in this type of injury, a graft would not survive. In addition, graft placed directly on bone with periosteum would be very vulnerable to breakdown from minor trauma. Bone allografting can be used to bridge defects in many circumstances. In the patient described, the severe contamination of the initial injury would make bone allografting much less appealing than autografting. Because of contamination, any type of bone grafting may need to be delayed until after achieving stable soft tissue coverage of the fracture. A pedicled gastrocnemius muscle flap provides excellent coverage for defects about the knee, including the proximal tibia. Although the free gastrocnemius muscle flap could be transferred to any location, the pedicled flap would not be able to reach the distal tibia.

Answer 74

The correct response is Option A. The injury in the patient described is to the common peroneal nerve. Both the first web space of the foot and the extensor hallucis longus and tibialis anterior muscles are innervated by branches of the common peroneal nerve. The finding of absence of sensation over the medial aspect of the calf and weakness of the soleus and extensor digitorum brevis muscles is eliminated by numbness of the medial calf, which is innervated by the saphenous nerve, a branch of the femoral nerve. Absence of sensation over the medial malleolus and heel with weakness of the soleus and tibialis anterior muscles is eliminated by numbness of the medial malleolus, which is also innervated by the saphenous nerve. In addition, the soleus is innervated by the tibial nerve. The finding of absence of sensation in the third web space of the foot and weakness of the soleus and extensor digitorum brevis muscles is eliminated by the soleus muscle. The finding of absence of sensation over the upper lateral calf and weakness of the flexor hallucis longus and extensor digitorum brevis muscles is eliminated by the flexor hallucis longus, which is innervated by the tibial nerve.

Answer 75

The correct response is Option C. The patient displays the signs and symptoms of acute compartment syndrome, a surgical emergency requiring emergent fasciotomy. Acute compartment syndrome requires prompt diagnosis and expeditious treatment in order to minimize morbidity. Compartment syndrome can occur following a substantial soft tissue crush injury, even in the absence of a fracture, such as in this clinical scenario. Severe pain is usually the presenting complaint. It may be out of proportion to the injury and unresponsive to analgesics. The presence of paresthesias can signify nerve hypoxia from elevated compartment pressures. Pallor, paralysis, and pulselessness are very late signs. Nerve and muscle do not tolerate long periods of ischemia and may undergo irreversible damage if surgical decompression is delayed. Compartment syndrome is primarily a clinical diagnosis, but measurement of compartment pressures can provide additional information especially if the diagnosis of compartment syndrome is less obvious. If compartment pressures are greater than 30 mmHg or if the differential pressure (difference between diastolic blood pressure and compartment pressure) is less than 30 mmHg, then fasciotomy is recommended. Observation and leg elevation would not be appropriate management in the setting of acute compartment syndrome. CT angiography would not be indicated in this case, where there is a low suspicion of vascular injury. MRI has been used in the diagnosis of chronic exertional compartment syndrome but has little value in the setting of acute trauma.

Answer 76

The correct answer is option a. This 53-year-old man with a nonhealing wound has most likely developed osteomyelitis of the foot, which may be caused by direct, penetrating trauma to the bone or contiguous spread from adjacent soft tissue. The calcaneus is the most common site of involvement in the foot, followed by the metatarsals and the cuboid bone. Although osteomyelitis may be suspected clinically, definitive diagnosis is accomplished with bone biopsy and culture. This can be obtained by needle aspiration of the interosseous or subperiosteal space. Cultures of a draining wound are less accurate diagnostically than bone biopsy and culture. Findings on bone scan are nonspecific and are often positive in patients with local wound infection or cellulitis. CT scans are not used in the diagnosis of osteomyelitis. Although MRI is more accurate than bone scan, it cannot be used to establish a definitive diagnosis.

Answer 77

The correct response is Option D. Posttraumatic reconstruction of the lower extremities with significant soft-tissue defects that expose bone, joints and tendons generally require free tissue transfer. The Gustilo-Anderson fracture classification system is widely used to describe the injury when associated with a long bone fracture. Gustilo type IIIB fractures are associated with periosteal stripping and exposure of bone with contamination. In 1986, Godina emphasized coverage of these soft-tissue defects within the first 72 hours of injury. Given the nature of these poly-trauma injuries, coverage of these wounds is not always possible in the given time frame. Staged debridement and negative pressure therapy have become common in the management of these injuries. Inadequate bone or soft-tissue debridement prior to reconstruction is a common cause of failure. The wound has to be free of all contaminants prior to reconstruction; thus, it is unlikely that an 8-day delay is the cause of breakdown. Distal flap necrosis would show more superficial breakdown and, in this case, is not the cause for a deep space infection. The patient's age does not have any bearing on this complication.

Answer 78

The correct response is Option B. Osteomyelitis is a frequent complication of open fractures associated with soft-tissue injury, fibrosis, and localized ischemia. Measures to prevent the development of osteomyelitis, including removal of dead and devitalized bone, closure of dead space, and coverage with well-vascularized soft tissue, are recommended. In patients with established osteomyelitis, the most appropriate initial management is debridement of devascularized bone and necrotic or scarred tissues and removal of any nonautologous material, such as fixation devices. Because local soft tissue is frequently inadequate, free tissue transfer is often performed for soft-tissue coverage in the lower third of the leg. In patients who have unhealed fractures, an external fixation device is used to stabilize the fracture pattern. An Ilizarov frame may be applied if lengthening is required. Continuous irrigation alone will not treat the osteomyelitis. Coverage with a well-vascularized muscle flap should be performed following bony debridement, and bone grafting should be delayed until the bone and soft tissues are stabilized and the osteomyelitis has resolved. Insertion of an intramedullary rod may further compromise bony perfusion.

Answer 79

Correct answer is option C. Patients who sustain open fractures of the long bones are susceptible to bacterial invasion of the wound site and the subsequent development of infection, especially osteomyelitis. Factors associated with persistent infection include the presence of dead space at the surgical site, inadequate soft-tissue coverage, the presence of nonviable soft tissue, including muscle, and retention of devitalized bone. Aggressive irrigation and debridement should be performed in any patient with an open fracture. All nonviable tissue must be removed, and the fracture site should be covered with adequate soft tissue from a local site or via a free tissue transfer. Internal fixation has not been associated with development of osteomyelitis in patients who have open fractures of the tibia and/or fibula.

Answer 80

Correct answer is option E. This patient has sustained multiple traumas including injury to the skin, bone, arteries, and nerves. Using the injury severity scale, the prognosis of this injury is very poor. In an adult, there is little chance of regaining useful protective sensation or motor function after nerve repair in light of the open fractures and vascular injury. The best immediate management is amputation. Additionally, the return to weight-bearing and work is significantly shorter with amputation.

Answer 81

The correct response is Option A. The most commonly injured nerve in the leg is the common peroneal nerve because of its superficial location as it courses around the neck of the fibula. The common peroneal nerve then divides into the superficial and deep branches. The superficial branch will evert the foot by innervating the lateral compartment of the leg, while the deep branch will dorsiflex the foot by innervating the anterior compartment. The superficial branch also provides sensation for the anterior and lateral sides of the leg and the majority of the dorsum of the foot and toes, including the medial side of the big toe. Paralysis of the common peroneal nerve would lead to foot drop and foot inversion, abnormal “steppage” gait, and loss of sensation.

Answer 82

The correct response is Option C. Lower extremity osteomyelitis following trauma is a challenging problem with high complication rates. The key to success is adequate debridement of both bone and soft tissue followed by coverage with vascularized tissue. The patient described had debridement of soft tissue but not bone. The bone is a persistent source of infection and the scarred fibrotic soft tissue is poorly vascularized, thus crippling the immune response. Without adequate bone debridement, early recurrence is likely. Muscle flaps fill the resultant defect, enhance blood flow, and improve immunologic defense against microorganisms. The scapula flap can easily provide skin paddles of 10 × 15 cm; therefore, closure under tension would not be a problem.

Answer 83

The correct response is Option E. This patient has sustained multiple traumas including injury to the skin, bone, arteries, and nerves. Using the injury severity scale, the prognosis of this injury is very poor. In an adult, there is little chance of regaining useful protective sensation or motor function after nerve repair in light of the open fractures and vascular injury. The best immediate management is amputation. Additionally, the return to weight-bearing and work is significantly shorter with amputation.

Answer 84

The correct response is Option C. Patients who sustain open fractures of the long bones are susceptible to bacterial invasion of the wound site and the subsequent development of infection, especially osteomyelitis. Factors associated with persistent infection include the presence of dead space at the surgical site, inadequate soft-tissue coverage, the presence of nonviable soft tissue, including muscle, and retention of devitalized bone. Aggressive irrigation and debridement should be performed in any patient with an open fracture. All nonviable tissue must be removed, and the fracture site should be covered with adequate soft tissue from a local site or via a free tissue transfer. Internal fixation has not been associated with development of osteomyelitis in patients who have open fractures of the tibia and/or fibula.

Answer 85

The correct response is Option C. The gastrocnemius is a powerful muscle in the superficial posterior compartment of the leg that acts to plantar flex the foot at the ankle joint and flex the leg at the knee joint. It is involved in standing, walking, running, and jumping. The lateral head originates from the lateral condyle of the femur, while the medial head originates from the medial condyle of the femur. Its other end forms a common tendon with the soleus muscle; this tendon is known as the calcaneal tendon or ?Achilles tendon? and inserts onto the posterior surface of the calcaneus.The medial head is longer, and its muscular fibers extend more inferiorly. The gastrocnemius can be harvested as a muscular or musculocutaneous flap if the soleus is intact and plantar flexion of the foot will be preserved. Medial and lateral heads may be used independently based on the tissue defect present. Footdrop is possible with the use of the lateral muscle belly.The soleus is the other powerful muscle of the superficial posterior compartment of the leg. With the gastrocnemius, it acts to plantar flex the foot at the ankle joint. Specifically, the soleus plays an important role in standing; if not for its constant pull, the body would fall forward. The muscle originates from the posterior surfaces of the head of the fibula and its upper quarter, as well as the middle third of the medial border of the tibia. Its other end forms a common calcaneal tendon with the gastrocnemius muscle.The soleus muscle, when freed from its insertion on the Achilles tendon and based proximally, covers defects in the middle third of the tibia. It may also be used as a hemisoleus to cover distal third tibia defects as well.The sartorius flap may be raised as a muscle or myocutaneous flap based on segmental branches of the superficial femoral artery and vein. Because it has a Type IV segmental blood supply, the arc of rotation both superiorly and inferiorly is limited. Its best indication is for coverage of the femoral vessels.

Answer 86

The correct response is Option A. Godina defined the timing of posttraumatic microsurgical lower extremity reconstruction in 1986 with recommendations for flap coverage of Gustilo Type IIIB/C fractures within 72 hours of injury. Godina's study showed the highest risk of infection and flap loss in the delayed period (72 hours to 90 days). Subsequent authors have also cited lower rates of flap loss and infection when repair was performed. Many authors have reported good flap survival when surgery is done within 3 days and 3 months after injury, but it is accepted that this delayed time frame necessitates more meticulous dissection and going well outside the zone of injury to a patent venous system to decrease the incidence of free flap loss.

Answer 87

The correct response is Option E. The medial instep flap (or medial plantar artery flap) is an ideal choice for coverage of a heel defect in a patient with adequate peripheral vasculature. This flap is based on the medial plantar branch of the posterior tibial artery. This vessel lies between the abductor hallucis and flexor digitorum brevis muscles. The lateral plantar artery supplies the lateral aspect of the sole and digits but does not supply the medial instep. The anterior tibial artery and dorsalis pedis supply the dorsum of the foot and digits and are not involved in this flap. The peroneal artery is used in a fibular flap but not in the foot.

Answer 88

Correct answer is option B. This patient has early wound dehiscence after undergoing open reduction and internal fixation of a lateral malleolus fracture. Appropriate management involves early coverage of the exposed bone and hardware to promote bony union while preventing bacterial colonization of the hardware, which may lead to the development of osteomyelitis. Because this patient underwent open reduction and internal fixation only two weeks ago, fixation is still required to maintain rigid fracture stabilization. Instead, coverage with a free flap is recommended to provide stability and vascularity and to enhance function once bony union is obtained. Skin grafting will not provide stable, well vascularized coverage in this patient. External fixation is problematic because of the location of the fracture. Removal of the hardware two weeks after fracture is indicated only for established hardware failure.

Answer 89

The correct answer is option A. As a more superficial vessel, the anterior tibial artery is the most commonly injured vessel in lower extremity trauma (30-60%). Chen 1994

Answer 90

The correct response is Option A. Anterior tarsal tunnel syndrome, also known as deep peroneal nerve (DPN) entrapment, is the result of compression of the DPN at the superior border of the inferior extensor retinaculum at the ankle joint and beneath the extensor hallucis longus tendon. Entrapment can occur as a result of wearing tight-fitting shoes or boots. It is important to rule out exertional anterior compartment syndrome or common peroneal nerve entrapment as the cause of symptoms. The nerve can also experience traction injury caused by chronic ankle instability due to ankle sprains. The DPN travels in the leg between the extensor digitorum longus (EDL) and tibialis anterior and distally between the EDL and extensor hallucis longus just proximal to the ankle before dividing into the lateral and medial branches, 1.3 cm proximal to the ankle joint. The lateral branch innervates the extensor digitorum brevis (EDB) and the tarsometatarsal (TMT) and metatarsophalangeal joints. The medial branch, a sensory branch, travels to the first dorsal web space and has a dorsomedial cutaneous branch to the second toe and a dorsolateral cutaneous branch to the great toe. Entrapment of the medial branch can occur from the extensor hallucis brevis (EHB) tendon, as it travels over the nerve at the first and second TMT joints. Patients typically present with pain along the dorsum of the foot with intermittent numbness radiating to the first dorsal web space. A Tinel sign may be elicited over the superior and inferior retinaculum along the DPN, resulting in tingling over the first dorsal web space of the foot. The EDB can be weak or atrophied. Patients may also report aching and tightness along the ankle joint or numbness at the first dorsal web space when the ankle is placed in plantar flexion with the toe extended. Electrodiagnostics should be ordered to confirm the diagnosis and location of the entrapment.

Answer 91

The correct answer is option C. Lower extremity edema following bypass is a common sequalae. In this surgical population, lymphangiogram studies have shown that iatrogenic lymphatic disruption, particularly in the inguinal and popliteal regions, are the most important cause of edema. DVTs should be ruled out and are not the most common cause of edema in these patients.

Answer 92

The correct response is Option C. When raising a reverse sural artery flap, the important landmarks are the lesser saphenous vein and sural nerve, which should bisect the cutaneous paddle. The blood supply to this flap depends on the medial superficial sural artery and the lesser saphenous vein with its two small accompanying arteries. The pivot point of the pedicle is typically 5 cm above the lateral malleolus, where the perforators of the flap enter a more superficial plane. The Achilles tendons are not landmarks for raising this flap but, when exposed, are good indications for this type of flap. The deep peroneal nerve is located in the lateral compartment. The posterior tibial artery is found in the deep compartment and is not associated with this flap. The plantaris tendon is deep to the dissection of the flap.

Answer 93

The correct response is Option C. Early amnion rupture with subsequent entanglement of fetal parts (mostly limbs and appendages) by amniotic strands is the primary theory of pathogenesis. A wide spectrum of clinical deformities is encountered and range from simple ring constrictions to major visceral defects. Lower extremity limb malformations are extremely common and consist of asymmetric digital ring constrictions, distal atrophy, congenital intrauterine amputations, acrosyndactyly, lymphedema, and clubfoot. Amniotic band syndrome is not a rare anomaly, as first described more than 150 years ago, and appears to be rising. Once believed to have an incidence of 1:100,000, recent literature supports the incidence today as 1:1200 to 1:5000 births. No distinct sex predilection has been determined. Nearly 60% of the cases documented have some sort of abnormal gestation history. Prenatal risk factors associated with amniotic band syndrome include prematurity (less than 37 weeks), low birth weight (less than 2500 g), maternal illness during pregnancy, maternal drug exposure, and maternal hemorrhage. Attempted abortion in the first trimester is also a highly associated finding. Family history seldom shows any direct inheritance pattern since the syndrome occurs in no particular association with known genetic or chromosomal disorders. The zone of polarizing activity signals the developing limb bud towards anterior/posterior polarity and does not result in truncation. Proximodistal limb growth is the result of the apical ectodermal ridge. Deletion of the gene responsible for the apical ectodermal ridge will result in shortening of the limb but not in congenital constriction band syndrome. Experiments in which the apical ectodermal ridge has been removed show truncated limb growth. Scientific evidence supports that the pattern of limb anomalies in the offspring of mothers exposed to exogenous retinoids, such as retinoic acid, causes interference with apical ectodermal ridge function, resulting in similar deformities. Thalidomide results in various limb deformities, including phocomelia, dysmelia, amelia, and bone hypoplasticity, with as little as a single dose of thalidomide during gestation. It does not, however, result in constriction bands. It is postulated that thalidomide-associated malformations are the result of the drug’s interference with vasculogensis.

Answer 94

The correct response is Option C. Common peroneal nerve repairs tend to have less favorable results than their upper extremity counterparts. Traction injuries showed only good outcomes in 42% of patients, whereas sharp injuries showed good results in 61% of patients. Gunshot wounds, on the other hand, showed only 49% good outcomes due to the blast injury. This patient had damage of his nerve from penetrating trauma from the fracture fragments as well as damage from the blast injury. Because of the size of the defect, primary nerve repair would not be feasible. Nerve grafts less than 6 cm have been found to have a more favorable result than those greater than 6 cm. When combined with blast injury, a favorable result has only been found in 31% of patients. In addition to nerve repairs, tendon transfers of the posterior tibial tendon have been useful for more immediate dorsiflexion. Fascicular nerve transfers have found some success in dorsiflexion. Of the options given, only transfer from the flexor hallucis longus (tibial nerve) to the tibialis anterior (deep peroneal nerve) would result in dorsiflexion. Although flexor digitorum longus is a common donor from the tibial nerve, innervating the soleus would result in plantar flexion and the soleus is also innervated by the tibial nerve, so it was not injured in the gunshot. Transfer from the flexor digitorum longus to the tibialis posterior (tibial nerve) would plantarflex the foot and not dorsiflex it. Although transfer to the extensor digitorum longus can lead to dorsiflexion, transfer from the peroneal longus (superficial peroneal nerve) to extensor digitorum longus would not result in a functional nerve repair, since the peroneal longus is innervated by the damaged nerve. Finally, transfer from the soleus to the extensor digitorum brevis (EDB, deep peroneal nerve) would not be a nearby transfer, nor would the EDB dorsiflex the ankle.

Answer 95

The correct response is Option D. The Gustilo classification of open fractures is based on the severity of soft-tissue injury and the presence or absence of concurrent vascular injury. A higher grade implies a more severe injury, and correlates with a greater incidence of complications and need for amputation. The patient in this item has a wound greater than 10 cm and a heavily comminuted tibia fracture. There is no mention of vascular injury. He has a Gustilo type IIIB injury. The Gustilo grading scale: TypeFindings IClean wound bed, simple/minimally comminuted bone injury, wound \< 1 cm IIWound contaminated, moderate comminution of bone, wound \> 1 cm IIIAWound highly contaminated, severe comminution, wound 1 to 10 cm IIIBWound highly contaminated, severe comminution, wound \> 10 cm IIICMajor vascular injury requiring repair for limb salvage

Answer 96

The correct response is Option E. When multiple tendon grafts are needed or when it is necessary to harvest grafts long enough to reach from the forearm to the fingertip, lower extremity tendon graft harvest is necessary. The plantaris tendon is a good source of tendon graft and is present in about 80% of limbs. The graft is harvested through a vertical incision just anterior to the medial aspect of the Achilles tendon. Then the graft is followed proximally using either a tendon stripper or with further incisions. As such, dissection of the plantaris tendon begins behind the medial malleolus and close to the tibial nerve. The sural nerve lies about the lateral malleolus and thus is not likely to be inadvertently injured during plantaris harvest. The medial plantar artery is on the sole of the foot and would be distal to the field of dissection. The extensor hallucis brevis muscle is a small muscle that lies over the dorsum of the foot and thus, like the dorsalis pedis artery, would not be injured in the dissection.

Answer 97

The correct response is Option B. Claw toe or loss of active flexion of the great toe interphalangeal joint can result from harvest of the flexor hallucis longus for free fibula flaps. The flexor hallucis longus is present within the deep posterior compartment of the lower leg and should be resuspended to the interosseus membrane and posterior tibial muscles as needed to maintain proper tension. Physical therapy is initiated after adequate wound healing to maintain the mobility of the great toe and ankle. The deep posterior compartment musculature is composed of the tibialis posterior, the flexor digitorum longus, the flexor hallucis longus, and the popliteus. The superficial posterior compartment musculature is composed of the gastrocnemius, soleus, and plantaris. The anterior compartment musculature is composed of the tibialis anterior, the extensor digitorum longus, extensor hallucis longus, and the peroneus tertius. The lateral compartment musculature is composed of the peroneus longus and brevis muscles.

Answer 98

The correct response is Option D. This Gustilo IIIB wound is best covered with a free muscle flap. The latissimus muscle flap is an effective and frequently used flap for large wounds. This flap also has the advantage of large vessels and a long pedicle length. Dressing changes followed by a skin graft will not provide durable coverage over the tibia, is not appropriate in a healthy teenager who is not at surgical risk, and the time delay to coverage may predispose the patient to the development of osteomyelitis. A neuroadipofascial flap based on the vessels accompanying the sural nerve would be a poor choice, as this would be harvested from the zone of injury. The soleus flap is traditionally used for middle third defects of the leg and also is within the zone of injury. This is a salvageable extremity in a young teenager, which makes amputation inappropriate.

Answer 99

The correct response is Option A. This 53-year-old man with a nonhealing wound has most likely developed osteomyelitis of the foot, which may be caused by direct, penetrating trauma to the bone or contiguous spread from adjacent soft tissue. The calcaneus is the most common site of involvement in the foot, followed by the metatarsals and the cuboid bone. Although osteomyelitis may be suspected clinically, definitive diagnosis is accomplished with bone biopsy and culture. This can be obtained by needle aspiration of the interosseous or subperiosteal space. Cultures of a draining wound are less accurate diagnostically than bone biopsy and culture. Findings on bone scan are nonspecific and are often positive in patients with local wound infection or cellulitis. CT scans are not used in the diagnosis of osteomyelitis. Although MRI is more accurate than bone scan, it cannot be used to establish a definitive diagnosis.

Answer 100

The correct response is Option D. Anatomic dissections by Drs. Grabb and Argenta found that the lateral calcaneal artery is usually the terminal branch of the peroneal artery but occasionally may arise from the posterior tibial artery. The branches of the peroneal include the nutrient artery which supplies the fibula, the perforating branch which gives branches to the tarsus, the communicating branch and the lateral calcaneal.

Answer 101

The correct answer is option B. Lower extremity fractures with combined soft-tissue and neurovascular trauma have high rates of complications, and a percentage of these injuries lead to amputation. Risk factors for amputation include Gustilo IIIC injuries, sciatic or tibial nerve injuries, prolonged ischemia (more than 4 to 6 hours), significant soft-tissue injury, significant wound contamination, multiple injured extremities, advanced age, lower versus upper extremity trauma, and futile attempt at revascularization. While tibial nerve injury is a risk factor and relative indication for amputation, it is never an absolute indication for amputation. Hard signs for vascular injury include: active hemorrhage, expanding hematoma, bruit or thrill, absent distal pulses, and distal ischemic signs and symptoms (five P’s). In the face of these hard signs, imaging such as CT angiography should be used to evaluate for vascular injury. With that said, most hard signs can be explained by soft-tissue or bone bleeding, traction of intact arteries due to unreduced fractures, or compartment syndrome. Early soft-tissue coverage is associated with a lower complication rate. The goal is to close wounds within 7 to 10 days to decrease the risk for infection, osteomyelitis, nonunion, and further tissue loss. It is best to get wound control prior to bone grafting, avoiding the risk of losing valuable limited bone; therefore, bone grafting is generally postponed until 8 to 10 weeks after soft-tissue wound coverage.

Answer 102

The correct response is Option C. The answer is debridement with repair of the tibial nerve and coverage with an anterolateral thigh (ALT) free flap. This patient is presenting with a grade IIIB open fracture of the distal tibia and fibula with an open medial wound. Traditionally, lower extremity injuries with an insensate plantar foot were considered unsalvageable. However, more recent data have demonstrated that an insensate foot by itself should not be considered a contraindication to limb salvage if repair is otherwise possible. Studies have shown equivalent long-term outcomes with limb salvage and primary amputation and that half of the patients with tibial nerve injuries will regain plantar sensation within two years post-injury. This vignette describes a situation in which one could reasonably expect a successful outcome. The size and location of the wound are most amenable to coverage with a microvascular free flap. In this instance, a fasciocutaneous flap will provide adequate soft-tissue coverage with minimal donor morbidity and potentially better long-term outcome if secondary bone grafting or hardware revision is required. The reverse sural fasciocutaneous is a versatile flap that can be used for reconstruction of many different wounds of the distal lower extremity. The flap is a neurocutaneous flap supplied by the vascular axis of the sural nerve as well as distal peroneal artery perforators. In this case, the peroneal artery was damaged from the trauma and the pedicle of the flap is in the zone of injury, making it an inappropriate choice for reconstruction when better options are available. The use of biologic materials such as bilaminar acellular dermal regeneration templates have been used successfully to cover wounds with exposed vital structures such as bone, tendon, and nerve. However, its use is best suited for smaller wounds or in patients in whom microvascular reconstruction is contraindicated or not desired. This patient required soft-tissue coverage over a major nerve repair and a comminuted fracture with internal hardware. A microvascular free flap would be the method of choice in this patient when feasible. As stated previously, up to fifty percent of patients with tibial nerve injuries will recover plantar sensation after nerve repair. Nerve repair should be attempted to improve the overall outcome.

Answer 103

Correct answer is option a. Superficial peroneal nerve is very superficial at the area between the anterior and lateral compartments near the proximal fibula (near the fibular head). The two incision technique will be in close proximity to the superficial peroneal nerve. -

Answer 104

The correct response is Option D. The utility of the flap has been proven in both healthy and compromised wounds; neither peripheral arterial disease nor diabetes has precluded its success. Of the possible complications, partial flap loss has occurred most commonly. As a result, numerous modifications to the flap have been proposed. These include maintaining a narrow (2 cm wide) pedicle, including a cutaneous ?tail? along the length of the pedicle and maintaining a mesentery between the sural nerve and the deep fascia. Infection rates have been low, ranging from 0 to 2.5%. The fasciocutaneous variety of the reverse sural flap is often malleable enough to conform to most defects. When a deeper defect exists, a fasciomusculocutaneous variation of the flap has been designed to carry a portion of the gastrocnemius muscle via one of the larger proximal perforators typically found deep to the cutaneous paddle in the proximal leg. Cutaneous paddles have been harvested with dimensions of up to 12 × 15 cm, allowing coverage of most ankle and heel wounds. Reconstruction of larger donor defects with split-thickness skin grafts makes dehiscence unlikely.

Answer 105

The correct answer is option C. While historical studies showed muscle flaps had superior vascularity and better ability to decrease bacterial counts in wounds, these were compared to random pattern fasciocutaneous flaps, not free flaps with a known blood supply. More recent series have shown no difference in clearance of chronic osteomyelitis when comparing muscle and fasciocutaneous flaps. Thorough debridement is believed to be the most critical factor in treatment of osteomyelitis. Salgado 2005, Kovar 2019, Buono 2018 The correct answer is option C.

Answer 106

The correct answer is option B. This 28-year-old man has a markedly diminished dorsalis pedis pulse after sustaining a laceration of the anterior tibial artery when he was stabbed in the leg. Therefore, he is most likely to have numbness of the first web space of the foot on physical examination. The first web space is innervated by the deep peroneal nerve; this nerve courses within the anterior compartment of the leg with the anterior tibial artery, which becomes the dorsalis pedis artery in the foot. -The dorsal aspect of the foot (with the exception of the first web space) is innervated by the superficial peroneal nerve. -The lateral foot is innervated by the sural nerve, and the medial foot is innervated by the saphenous nerve. None of these nerves travels with an artery. The plantar surface of the foot is innervated by the tibial nerve, which courses within the deep posterior compartment of the leg with the posterior tibial artery.

Answer 107

The correct response is Option E. A recent meta-analysis of 61 papers showed that venous insufficiency is associated with a nine-fold increase in risk of developing a complication in a distally based sural flap. Other risk factors, such as peripheral vascular disease, diabetes, obesity, and hypertension, have been associated with increased rates of complications previously in the literature, but venous insufficiency is associated with the highest rate of complications. The pooled data from this series showed a 26% complication rate, a 3.2% flap loss rate, and a 15.3% partial flap loss rate. As the design of the sural flap is distally based, the physiology of the flap requires reversed flow through the venous system. Advanced age is also associated with an increased complication rate and there is literature to suggest a delay procedure in this patient population. Other papers have found smoking to have a higher risk of complications as well. There is still much debate over which patients should undergo a delay procedure or venous supercharging, but in general, high-risk patients with multiple comorbidities should be considered for this additional surgery. Coronary artery disease has not been found to be associated with increased risk of flap-related complications.

Answer 108

The correct response is Option E. Gustilo initially classified long-bone fractures into three types in order to establish a treatment algorithm. Essentially, this classification subdivided fractures according to the energy of the initial trauma that resulted in significant soft-tissue injury, periosteal stripping, and fracture comminution in the worst subtype. Debridement, antibiotics, and primary or delayed wound closure were advocated dependent on fracture severity. Type III fractures were subsequently subdivided into A, B, and C subtypes. Subtypes were stratified according to potential for complications such as infection, osteomyelitis, non-union, and amputation rates. Type IIIC had open fracture with arterial injury requiring repair (the case in this patient, even though there appears to be adequate soft-tissue coverage). Although fracture fixation methods have substantially improved since the original publications of Gustilo, the ability to transport bone into segmental traumatic defects has also since developed, and free flaps have extended our ability to cover large wounds. This classification system has stood the test of time and still forms the basis of prognosticating and determining the optimum treatment algorithm.

Answer 109

The correct response is Option A. Avulsion of the tibial nerve is one of the two absolute indications for amputation in the context of Gustilo Type IIIB and IIIC open tibial fractures. This is because outcomes of microsurgical reconstruction of the insensate foot in these cases are very poor. The other absolute contraindication to reconstruction is a warm ischemia time of 6 hours or greater, which the patient described does not have. The patient has just lost pulses after manipulation and fixation. This is a new finding, with very recent ischemia time. This is a potentially fixable situation, and not necessarily a contraindication to reconstruction. Recent loss of pulses could contribute to a need for amputation in the future but would not require that decision now. Polytrauma, such as a liver laceration or an intracranial injury, can evolve into relative contraindications to reconstruction, but they are not absolute contraindications by themselves. The liver laceration could resolve and allow safe microsurgical reconstruction. Even the delay of time to reconstruction that polytrauma can necessitate can be managed with bony fixation, wound care, and vacuum-assisted closure placement until construction of a flap can be performed. The loss of plantar skin and metatarsal fractures by themselves are also not an absolute contraindication to reconstruction. This is a potentially reconstructible problem that should not push the plastic surgeon to recommend amputation. The additional foot trauma can potentially be reconstructed either with a skin graft or a flap. The intracranial injury can evolve to a point where neurosurgery would eventually release the patient for a free flap. So, the parietal contusion is not necessarily an absolute contraindication to reconstruction, depending on the eventual outcome from the head injury. The patient may very well get better from that, and become a limb salvage candidate. It all depends on severity.

Answer 110

The correct response is Option C. This 35-year-old man with diabetes mellitus who previously underwent kidney transplantation has a large ulcer overlying the left Achilles tendon. Because of his immunosuppressive state and concomitant diabetes mellitus, he is most likely to experience cardiovascular problems, neuropathy, and poor wound healing following any type of reconstructive surgery. However, despite these potential adverse sequelae, free tissue transfer is most appropriate for management of the ulcer. Appropriate work-up should be obtained before attempting any reconstructive procedure. Growth factor therapy will not adequately heal this large ulcer. A skin graft alone is inappropriate for coverage of exposed tendons. Because amputations often increase cardiovascular demand in patients with diabetes mellitus, they should only be used as a last resort. An amputation is also inappropriate in a young patient because it will significantly alter his ability to perform activities of daily living. In addition, the Syme's amputation is used in wound management of the forefoot and not the distal calf.

Answer 111

The correct response is Option C. The sural nerve is located at the distal leg between the lateral malleolus and the Achilles tendon. The greater saphenous vein is located between the medial malleolus and the extensor hallucis longus tendon. The posterior tibial vessels are located between the medial malleolus and the Achilles tendon. The dorsalis pedis artery is located between the tendons of the tibialis anterior and the extensor hallucis longus.

Answer 112

The correct response is Option B. The saphenous artery supplies vascularity to the saphenous flap, a fasciocutaneous flap that provides only limited coverage of small defects in the region of the knee. The saphenous artery is a branch of the descending genicular artery. The genicular artery arises from the superficial femoral artery. The descending branch of the lateral femoral circumflex artery arises from the profunda femoris and continues distally in the leg as the superior lateral genicular artery. The profunda femoris artery gives off its major branches more proximally in the leg. The superficial femoral artery becomes the popliteal artery at the popliteal fossa.

Answer 113

The correct answer is option B. The patency rate of autogenous vein grafts for infra-popliteal bypasses is superior to that of prosthetic grafts. However prosthetic grafts may be used in limb salvage situations, as an alternative to amputation. Vein stripping (for patients with varicose veins) typically involves removal of the great saphenous vein. In such cases, alternate autologous options include the lesser saphenous, superficial femoral, basilic, or cephalic veins.

Answer 114

The correct response is Option E. This patient appears to demonstrate symptoms of a tibial nerve injury. The tibial nerve is a branch of the sciatic nerve. It travels through the popliteal fossa and gives off branches to gastrocnemius, soleus, plantaris, and popliteus muscles. The tibial nerve travels in proximity to the posterior tibial artery. In the leg, it gives off branches to the flexor digitorum longus, tibialis posterior, and flexor hallucis longus. Distally in the foot, it branches to give rise to the medial and lateral plantar nerves, which provide sensation to the plantar surface of the foot. Injury to the tibial nerve results in deficits of plantarflexion, as well as anesthesia to the plantar surface of the foot. The femoral nerve innervates muscles of the anterior thigh, including the quadriceps group, iliacus, and sartorius. Injury to the femoral nerve results in weakness of leg extension. The obturator nerve provides innervation to the medial thigh muscles (adductor group), including adductor brevis, longus, and magnus, as well as the gracilis and obturator externus. The cutaneous branch provides sensation of the medial thigh. Injury to the obturator nerve results in weakness in thigh adduction, and sensory deficits in the medial thigh. The peroneal nerve is divided into superficial and deep branches at the area of the fibular neck. The superficial peroneal nerve supplies the lateral compartment of the leg, giving motor branches to peroneus longus and brevis, as well as sensory contributions to the lateral aspect of the leg. Injury to the superficial peroneal nerve results in anesthesia of the lateral aspect of the leg and weakness in eversion and plantarflexion of the foot. The deep peroneal nerve travels in the anterior compartment of the leg, and gives branches to the tibialis anterior, extensor hallucis longus, and extensor digitorum longus and brevis, as well as peroneus tertius. The sensory distribution of the deep peroneal nerve is in the area of the first web space. Injury to the deep peroneal nerve causes weakness in dorsiflexion of the foot. The sural nerve travels on the posterior aspect of the leg between the lateral malleolus and calcaneus. It provides sensation to the lateral aspect of the foot, and does not have a motor component. It is commonly sampled in nerve biopsy and used as a source of nerve graft. Injury or sacrifice of the sural nerve would result in numbness of the lateral foot.

Answer 115

The correct response is Option D. Muscle flaps were “workhorses” for lower extremity reconstruction for years, but harvest of muscle always leaves some donor site functional morbidity because of loss of the muscle function. Survival rates, speed of dissection, and treatment of osteomyelitis are not significantly different between the flap types. Muscle flaps tend to fill dead space easier than fasciocutaneous flaps.

Answer 116

The correct answer is option B. Amputation is indicated in this patient who has obvious necrosis of the toe. Indeed, ischemic changes and wound problems are often seen in patients with diabetes mellitus. Because these patients are typically predisposed to further, more proximal amputations in the future, a conservative approach to amputation should be used in this instance. Several factors, including ankle-brachial index, help to predict the success rate in patients who undergo partial amputations of the foot; an ankle-brachial index of less than 0.7 indicates a markedly increased risk for wound healing problems following surgery. However, this patient has an ankle-brachial index of 0.76, which is an acceptable risk for complications following amputation. Therefore, an evaluation for the likelihood of revascularization should be undertaken prior to any amputation procedure. The surgeon should attempt to save as much of the foot as possible to allow for primary closure of the defect. As a result, the amputation should be performed at the metatarsal level in this patient. The surgeon should also be aware of the vascular supply to the adjacent toes during the amputation procedure in order to prevent any associated complications.

Answer 117

The correct response is Option E. The most appropriate next therapy option for this patient is systemic corticosteroids. These ulcerative lesions are most likely pyoderma gangrenosum (PG), an ulcerative cutaneous condition of unknown etiology. This condition is most likely associated with other systemic diseases like inflammatory bowel disease, or immunologic diseases. This diagnosis is usually one of exclusion, and one must have a high index of suspicion for ulcerative wounds that are persistent despite adequate workup and treatment. One must be especially aware of PG’s association with a condition known as pathergy. This is a phenomenon in which surgical manipulation of the area or distant sites may trigger worsening of the ulcerative condition and/or development of the condition in an area of skin trauma. First-line therapy for PG involves the use of prednisone. Other anti-inflammatory agents, including immunosuppressive agents, and biologic agents have also been used. The prognosis is generally good; however, the disease can recur and residual scarring is common. Because of these factors, the other options are not the most appropriate next steps in the treatment of this patient.

Answer 118

The correct response is Option C. The patient described has a Gustilo IIIC injury. Based on the best available data, he should undergo amputation. Ultimately, the choice to reconstruct versus amputate is a gestalt of the situation and the patient, as well as the capabilities of the hospital and the care team. In this case, the factors influencing the decision would be the warm ischemia time of 6 hours and severed posterior tibial nerve, as well as the extensive soft-tissue injury. Some of the newer data suggests that absence of plantar sensation is no longer criteria for amputation in and of itself. However, an anatomically disrupted nerve in an adult strongly favors amputation. In addition, there is evidence supporting the notion that limb salvage might involve less cost in the long term versus reconstruction. Gustilo Classification I: open fracture; clean; wound less than 1 cm II: open fracture; wound greater than 1 cm IIIA: open fracture; extensive soft-tissue injury but adequate tissue for coverage IIIB: open fracture; extensive soft-tissue injury but inadequate tissue for coverage IIIC: any of the above with a vascular (arterial) injury

Answer 119

The correct answer is A) Anterolateral thigh fasciocutaneous free flap Explanation: The anterolateral thigh (ALT) fasciocutaneous free flap is a reliable and versatile option for coverage of lower extremity defects. It provides robust vascularized coverage with minimal donor site morbidity, as it does not require harvesting muscle. For defects involving exposed bone and periosteal stripping, split-thickness skin grafts are unreliable. Rationale for other options: • B) Local gastrocnemius flap: This flap cannot reach defects in the distal third of the tibia or near the ankle. • C) Rectus abdominis myocutaneous flap: Although effective, it involves sacrificing a muscle, leading to higher donor site morbidity compared to the ALT flap. • D) Propeller flap based off the anterior tibial artery: This option is not viable in this case due to the lack of a significant perforating vessel as identified on CT angiography. • E) Split-thickness skin graft: This is not suitable for defects with exposed bone or periosteal stripping, as it requires a vascularized wound bed for survival. Key considerations for flap selection: Microsurgical techniques are feasible in elderly patients with peripheral vascular disease and provide optimal outcomes for complex wounds. ALT fasciocutaneous flaps are associated with excellent coverage, aesthetic outcomes, and minimal donor site morbidity. References: 1. Gohritz A, Osinga R, Haumer A, Schaefer DJ. Microsurgical reconstruction of the lower extremity in the elderly. Clin Plast Surg. 2021;48(2):331-340. doi:10.1016/j.cps.2021.01.008 2. Üstün GG, Aksu AE, Uzun H, Bitik O. The systematic review and meta-analysis of free flap safety in elderly patients. Microsurgery. 2017;37(5):442-450. doi:10.1002/micr.30156 3. Yang Z, Xu C, Zhu Y, et al. Flow-through free anterolateral thigh flap in reconstruction of severe limb injury. Ann Plast Surg. 2020;84(5S Suppl 3):S165-S170. doi:10.1097/SAP.0000000000002372

Answer 120

The correct answer is option B. This patient has early wound dehiscence after undergoing open reduction and internal fixation of a lateral malleolus fracture. Appropriate management involves early coverage of the exposed bone and hardware to promote bony union while preventing bacterial colonization of the hardware, which may lead to the development of osteomyelitis. Because this patient underwent open reduction and internal fixation only two weeks ago, fixation is still required to maintain rigid fracture stabilization. Instead, coverage with a free flap is recommended to provide stability and vascularity and to enhance function once bony union is obtained. Skin grafting will not provide stable, well vascularized coverage in this patient. External fixation is problematic because of the location of the fracture. Removal of the hardware two weeks after fracture is indicated only for established hardware failure.

Answer 121

The correct response is Option E. The anterolateral thigh (ALT) flap has proven to be one of the most versatile free tissue transfers in reconstructive surgery. Based on perforators from the descending branch of the lateral circumflex femoral artery that traverse the vastus lateralis (VL) (80%) or the septum between the rectus femoris and VL (18-20%), this flap can be fashioned as large as 10 cm wide by 25 cm long. Occasionally, no large perforator will be identified during dissection; in this circumstance, the flap may be carried on multiple perforators along with the vastus lateralis muscle. Branches of the lateral circumflex femoral artery also supply the sartorius (partial, as the supply is segmental), rectus femoris (descending branch), and tensor fascia lata (ascending branch). Vascular supply to the gluteus maximus arises from the superior and inferior gluteal arteries.

Answer 122

The correct response is Option B. Rhabdomyosarcomas represent the most common soft-tissue sarcoma of childhood and are responsible for approximately half of all soft-tissue sarcomas in this age group. They are thought to originate from immature cells that are destined to form striated skeletal muscle, although they can arise anywhere in the body. With modern multimodal management, the cure rates for localized disease are generally greater than 70% overall. The primary goal of local tumor control in extremity rhabdomyosarcoma is limb-sparing complete resection where possible. Vascularized bone grafting represents the gold standard for reconstructing segmental bone loss greater than 6 cm associated with a compromised local soft-tissue environment that occurs with radiotherapy and chemotherapy. For large weight-bearing intercalary reconstruction, significant literature supports the combination of a large structural allograft combined with vascularized fibula as described by Capanna in 1980. With this combination, the neoosteogenic properties of the free fibula are supplemented by the immediate structural support of the bulk allograft and provide a durable single-stage biological reconstruction. Distraction osteogenesis is a technique of de novo bone formation that capitalizes on normal bone healing with gradual, surgically controlled distraction of adjacent osteotomy defects and has the advantage of simultaneously expanding surrounding soft-tissue envelopes. The technique requires viable bone in proximity to one another following a latency phase and is useful in limb lengthening and craniofacial procedures but has limited utility in long segmental tumor reconstruction. The induced membrane technique proposed by Masquelet is a two-step procedure where a segment of bone loss is first filled with an acrylic spacer and later replaced by cancellous bone graft in the so-called self-induced reactive "periosteal" membrane. The technique requires two stages and is less favored in the setting of planned radiation or chemotherapy where experience has shown that vascularized flaps or supplemented vascularized allografts are beneficial. The medial femoral condyle flap has been used for small osteoperiosteal, corticoperiosteal, and osteocartilaginous flaps based off either the articular descending genicular or superomedial genicular arteries. It would be insufficient in size for a 20-cm-long bone defect. The Van Ness rotationplasty is a type of autograft where functional limb below the knee is used to reconstruct more proximal defects. It can be a useful “spare part” reconstructive option in composite proximal extremity resections by repurposing a functional ankle joint more proximally in a rotated configuration for preserved gait advantage at the repurposed knee. A rotationplasty would not be indicated for intercalary resections sparing joint and metaphysis.

Answer 123

The correct response is Option A. An understanding of the actions of donor muscles is necessary when using muscle flaps for reconstruction. A knowledge of the specific muscles, which are included as part of specific flaps also helps one understand what donor deficits may be produced when using a particular flap. The anterolateral thigh (ALT) flap perforators often traverse part of the vastus lateralis muscle, and the muscle may need to be dissected and therefore can be injured during flap harvest. It is rare that any long-term sequelae, such as weakness, are noted without muscle harvest. If the muscle is taken, as is often necessary for the filling of a dead space, weakness of knee extension may be noted as the vastus lateralis is a large part of the quadriceps muscle of the thigh, which is primarily responsible for knee extension. Thigh abduction is accomplished by the tensor fascia lata and sartorius muscles. The pectineus, adductor longus and brevis, gracilis, and adductor magnus are responsible for thigh adduction. Thigh flexion is achieved by the pectineus, adductor brevis, and adductor magnus. Knee flexion is done primarily by the hamstrings-semitendinosus, semimembranosus, and biceps femoris muscles.

Answer 124

The correct response is Option C. Targeted muscle reinnervation (TMR), as originally described by Dumanian and Kuiken, is a procedure in which sensory and/or mixed nerves are transferred or coapted to motor nerve branches, in an effort to promote organized nerve growth and also to improve prosthetic control. While initially explored for improvement of prosthetic functionality, researchers observed a concomitant reduction in neuropathic and residual limb pain. Though more research is needed, targeted muscle reinnervation may be most successful in decreasing or preventing pain when performed at the time of the amputation. The natural history of pain following TMR performed secondarily (not at the time amputation) includes a period of immediate relief (nerves are cut proximal to the neuroma), followed by activation of the nerves and increased pain (3 to 6 weeks), and plateau and reduction of pain (6 weeks to 6 months). Nearly all patients report a decrease in pain and improvement in quality of life. The degree with which the pain is decreased and life is improved may be related to the timing of the operation. Data suggest that the earlier the operation is performed, the better the results, perhaps because of the centralization of the somatic pain response, though more work is needed to elucidate this mechanism.

Answer 125

The correct response is Option E. Peroneal nerve palsy may lead to severe disability with footdrop and paresthesia. Traumatic peroneal palsy may result from supracondylar femoral fracture, knee dislocation, and proximal tibial fracture involving both motor and sensory changes. On examination, the motor deficit manifests as a footdrop, and the sensory deficit results in a loss of sensation along the dorsum of the foot. Unlike the loss of sensation associated with the peroneal nerve, the posterior tibial nerve is clinically morbid, as it is on the plantar aspect of the foot. The chronic injury may result in wounding of the plantar aspect of the foot, which may ultimately result in amputation. Electrodiagnostic testing should be performed within 1 month of the injury to confirm sensory and motor deficits. In patients with partial nerve palsy, greater than 80% will recover completely and can be expected to recover with observation alone. A patient with complete palsy will have a much worse prognosis, with only 40% of patients with a functional recovery. If there is no neurologic improvement after 2 to 3 months, operative decompression should be performed. If the nerve is noted to be in continuity, and nerve action potentials are transmitted across a lesion, then there may be continuity of the nerve, and neurolysis is performed. If there is a transected nerve, a direct repair or nerve grafting may be performed. When neurolysis and nerve grafting do not provide satisfactory results, the remaining surgical options are salvage procedures such as tendon transfer or arthrodesis. Posterior tibial tendon transfer is the most commonly used tendon transfer for this injury.

Answer 126

The correct response is Option E. The most likely nerve to be injured is the tibial nerve. The tibial nerve is a branch of the sciatic nerve. It travels through the popliteal fossa and gives off branches to the gastrocnemius, soleus, plantaris, and popliteus muscles. The tibial nerve travels in proximity to the posterior tibial artery. In the leg, it gives off branches to the flexor digitorum longus, tibialis posterior, and flexor hallucis longus. Distally in the foot, it branches to give rise to the medial and lateral plantar nerves, which provide sensation to the plantar surface of the foot. Injury to the tibial nerve results in deficits of plantar flexion, as well as anesthesia to the plantar surface of the foot. Tibial nerve disruption has been considered an indication for amputation as opposed to limb salvage in traumatic injuries of the lower extremity. However, one study suggests that limb salvage can be performed even in the face of absent plantar sensation at the time of presentation. This may indicate that absence of plantar sensation is not a reliable correlate for tibial nerve disruption. The deep peroneal nerve arises from the common peroneal nerve at the fibular neck. It travels in the anterior compartment of the leg and gives branches to the tibialis anterior, extensor hallucis longus, and extensor digitorum longus and brevis, as well as peroneus tertius. The sensory distribution is in the area of the first web space. Injury to the deep peroneal nerve causes weakness in dorsiflexion of the foot. The femoral nerve innervates muscles of the anterior thigh, including the quadriceps group, iliacus, and sartorius. Injury to the femoral nerve results in weakness of leg extension. The superficial peroneal nerve arises from the common peroneal nerve at the fibular neck. It supplies the lateral compartment of the leg, giving motor branches to peroneus longus and brevis, as well as sensory contribution to the lateral aspect of the leg. Injury to the superficial peroneal nerve results in anesthesia of the lateral aspect of the leg and weakness in eversion and plantar flexion of the foot. The obturator nerve provides innervation to the medial thigh muscles (adductor group), including adductor brevis, longus, and magnus, as well as the gracilis and obturator externus. The cutaneous branch provides sensation of the medial thigh. Injury to the obturator nerve results in weakness in thigh adduction and sensory deficits in the medial thigh.

Answer 127

The correct answer is option D. femoral artery cut down and embolectomy- this is threatened limb ischemia and should be treated emergently. Presentation also consistent with embolus. If patient had motor/sensory and femoral pulse, catheter directed TPA would be preferred as embolus would be more distal.

Answer 128

The correct response is Option E. The sartorius muscle has a Type IV vascularization pattern consisting of 8 to 10 pedicles from the superficial femoral vessel, which enter the muscle medially. The other arteries do not contribute to the blood supply of the sartorius muscle.

Answer 129

The correct response is Option D. This defect may be reconstructed with a posterior tibial artery perforator propeller flap. These vessels emerge between the flexor digitorum longus and the soleus muscle. In one anatomic study, there were three clusters of perforators: 4 to 9 cm, 13 to 18 cm, and 21 to 26 cm from the intermalleolar line. The peroneal artery perforators often arise through the posterior peroneal septum, and the anterior tibial artery perforators are often found between the extensor digitorum longus and the peroneus longus or between the tibialis anterior and the extensor digitorum longus.

Answer 130

The correct response is Option A. This patient is manifesting signs and symptoms of progressive acute compartment syndrome (ACS). ACS is a surgical emergency, and the next step in management is acute fasciotomy to fully decompress all involved compartments. Delays in fasciotomy increase unrecoverable tissue injury leading to permanent functional loss and morbidity such as muscle contractures, sensory deficits, paralysis, and infection. Compartment syndrome occurs when increased pressures within unyielding fascial compartments lead to progressive cellular anoxic injury to tissues within the compartment. Symptoms of ACS include pain out of proportion to injury and deep aching or burning pain. Complaints of paresthesia suggest progressive ischemic nerve dysfunction. Signs of ACS include pain with passive ranging of muscles in the affected compartment, a tense compartment with a firm and indurated "woody" feeling, and diminished sensation. Most cases of ACS occur with long-bone fractures, and risk increases with comminuted fractures. Other common forms of trauma including crush injury, severe thermal burns, constrictive bandages, penetrating trauma, vascular injuries, and ischemia-reperfusion injuries can lead to ACS. The anterior compartment of the leg is the most common site for ACS. Early signs of ACS affecting this compartment include loss of sensation in the distribution of the deep peroneal nerve, and weakness of dorsiflexion. Normal compartment pressures fall between 0 and 8 mmHg. Pain develops as compartment pressures increase, and tissue ischemia occurs as compartment pressures approach diastolic pressure. Differences between diastolic blood pressure and measured compartment pressure (delta pressure) less than 20 to 30 mmHg indicate a need for fasciotomy. As ACS evolves, muscle breakdown can lead to elevations in serum creatine kinase and myoglobinuria. Sensory deficits typically preclude motor deficits and EMG abnormalities progressing to total paralysis will occur. These are relatively late findings in ACS; they should not delay fasciotomy once progressive ACS is diagnosed. There is no diagnostic role for withholding analgesics in extremity trauma.

Answer 131

Correct answer is option E. The reverse sural artery flap is based on septocutaneous perforators from the peroneal and posterior tibial arteries. The dorsalis pedis artery passes beneath the extensor digitorum brevis tendon slip to the great toe. The sural nerve and its vasa nervorum are also included in the flap and may assist with vascularity. Mann 1980, Follmar 2007, Cheon 2008, Suri 2010 correct answer is option E.

Answer 132

The correct response is Option D. Propeller flaps are a useful method of lower extremity reconstruction. These flaps were initially popularized by Teo and have been utilized for a variety of defects in the lower leg and foot. The propeller flap is based on perforating blood vessels from the peroneal artery to reconstruct lateral defects and perforators from the posterior tibial artery to reconstruct defects on the medial aspect of the leg wound. The propeller flaps can often replace the need for a sural artery, neurocutaneous artery flap or a free tissue transfer. Laterally based plantar flaps may be used to cover small defects on the weight-bearing surface of the foot but are not reliable for larger or lateral defects. The posterior and anterior tibial arteries do not have perforator in the desired location for a distally based propeller flap. The lateral sural vessels are too proximal for heel coverage.

Answer 133

The correct answer is option E. The predominant blood supply to the reverse sural artery flap relies on perforators from the peroneal artery, which primarily originate at a point 5 cm proximal to the lateral malleolus. The median superficial sural artery and perforators from the gastrocnemius are involved in anterograde blood supply to the flap. Thus, these vessels are typically ligated in the reverse form of the flap. Likewise, injury to the lesser saphenous vein would not cause significant problems with venous outflow. In dissections and venous flow studies, small concomitant veins were found along both sides of the lesser saphenous vein and were considered to be venae comitantes of accompanying arteries of the vein. These accompanying veins played a role in bypassing the valves of the lesser saphenous vein. The sural artery flap can be harvested as a neural-veno-adipofascial flap. In this context, the sural nerve can used to provide sensation to the flap. This nerve does not provide primary blood supply to the flap, and injury would not compromise flap viability.

Answer 134

The correct response is Option D. Hypertension does not preclude the use of any fasciocutaneous flaps in the lower extremity. Diabetes mellitus can be associated with peripheral vascular disease, but by itself, would not prevent successful use of the reverse sural artery flap for foot or ankle reconstruction. Appropriate preoperative workup would include noninvasive ultrasound study of the lower extremity vasculature to prove the peroneal artery was patent. Vascularized flaps, including the reverse sural artery flap, provide excellent coverage for foot/ankle wounds, including those with underlying osteomyelitis. Effective treatment would necessitate adequate debridement and antibiotic therapy as part of the reconstructive paradigm. The distally based sural artery flap receives its blood supply from a few sources, the most robust of which are perforators from the peroneal artery. The most distal of these perforators arise between 4 and 7 cm proximal to the lateral malleolus. Additional perfusion arises from neurocutaneous perforators from the sural nerve and venocutaneous perforators from the lesser saphenous vein.

Answer 135

The correct response is Option D. Posttraumatic reconstruction of the lower extremities with significant soft-tissue defects that expose bone, joints and tendons generally require free tissue transfer. The Gustilo-Anderson fracture classification system is widely used to describe the injury when associated with a long bone fracture. Gustilo type IIIB fractures are associated with periosteal stripping and exposure of bone with contamination. In 1986, Godina emphasized coverage of these soft-tissue defects within the first 72 hours of injury. Given the nature of these poly-trauma injuries, coverage of these wounds is not always possible in the given time frame. Staged debridement and negative pressure therapy have become common in the management of these injuries. Inadequate bone or soft-tissue debridement prior to reconstruction is a common cause of failure. The wound has to be free of all contaminants prior to reconstruction; thus, it is unlikely that an 8-day delay is the cause of breakdown. Distal flap necrosis would show more superficial breakdown and, in this case, is not the cause for a deep space infection. The patient's age does not have any bearing on this complication.

Answer 136

The correct answer is option D. Atherosclerosis is a progressive disease that exists on a continuum. Fatty streaks are the **first visible evidence** of atherosclerosis and develop early in life. The process of fatty streak development is *initiated by endothelial injury and dysfunction*, caused by hypercholesterolemia, diabetes, smoking, etc. As lipids accumulate within the vessel wall, leukocytes migrate and form **foam cells (macrophages containing cholesterol)**. Next, **smooth muscle cells proliferate** within the intima and the fatty streak progresses to a **plaque**. Thus smooth cell regression is not a stage of atherosclerosis.

Answer 137

The correct response is Option B. The treatment goal in the management of open tibial fractures and lower extremity salvage is to preserve a limb that will be more functional than an amputation. If the extremity cannot be salvaged, the goal is to maintain the maximum functional length. Given the advanced age of the patient described, his associated injuries, and an insensate injured lower extremity, the most appropriate management of the injured leg would be a below-knee amputation. Below-knee amputations provide better prosthetic function and require less energy for ambulation than above-knee amputations. Although improved microvascular techniques have allowed for nerve repair and nerve grafting, the results of nerve repair and grafting in the lower extremity have been poor. In addition, the repair of the posterior tibial artery would not be necessary if the anterior tibial and peroneal arteries were to remain patent. Free tissue transfer might be indicated for the soft-tissue defect. However, any anticoagulation used would increase the chance of serious bleeding complications because the patient is being treated nonoperatively for a splenic laceration. Skin grafting over exposed bone would not be a good option.

Answer 138

**The correct answer is option C.** **Rationale:** The superficial peroneal nerve innervates the peroneus longus and brevis muscles in the lateral compartment, which are responsible for foot eversion. It also provides sensory innervation to the lateral aspect of the leg. The location of the injury (below the fibular head) and the specific deficits—weakness in eversion with preserved dorsiflexion (which is mediated by the deep peroneal nerve)—point specifically to an isolated superficial peroneal nerve injury. The deep peroneal nerve (option A) controls dorsiflexion and sensation in the first web space. The tibial nerve (option D) controls plantar flexion. The femoral (option B) and sural (option E) nerves do not match the motor or sensory deficits described. **References:** 1. Agur AMR, Dalley AF. Lower limb. In: Grant's Atlas of Anatomy. 15th ed. Lippincott Williams and Wilkins; 2020:471-584. 2. Kasabian AK, Karp NS. Lower-extremity reconstruction. In: Grabb and Smith's Plastic Surgery. 7th ed. Lippincott Williams and Wilkins; 2014:941-954.

Answer 139

The correct answer is option D. An MRI should be performed in this patient to exclude a diagnosis of osteomyelitis. Although all of the imaging studies listed above will show abnormalities of bone, only a gadolinium-enhanced MRI will delineate the signal characteristics of bone marrow and specific enhancement pattern characteristic of osteomyelitis. Measurement of erythrocyte sedimentation rate is highly sensitive but nonspecific for osteomyelitis; this test is used instead as a follow-up for determining the efficacy of treatment in patients previously diagnosed with osteomyelitis. High-resolution CT scans are inferior to MRI for diagnosis of osteomyelitis.

Answer 140

Correct answer is option B. The anterolateral thigh free flap is supplied by perforators of the descending branch of the lateral circumflex femoral artery. The tensor fascia lata flap is supplied by the ascending, transverse, and descending branches. The gracilis flap is supplied by the medial circumflex femoral artery. The saphenous and medial condylar flaps are supplied by the saphenous artery. Ali 2009.

Answer 141

The correct response is Option B. The pedicled gastrocnemius flap has been shown to be a reliable source of vascularized soft tissue for injuries of the distal thigh, knee, and proximal leg. The lateral or medial head may be harvested. Lateral gastrocnemius harvest risks damaging the common peroneal nerve, with an incidence of 7.7%. Medial gastrocnemius harvest, for obvious anatomical reasons, does not carry this risk. There are few data on the morbidity of donor sites, but those studies that have been done demonstrate no functional debility at a walking gait for less than 200 m. Patients do notice difficulty standing on their toes and have slowing with variable calcaneal gait when walking fast. Forty-two percent of patients could run, 22% had pain in the donor site at rest, and 20% had pain when walking more than 200 m. Seventy percent had pain and weakness in the operated leg when attempting to run. Range-of-motion deficit existed in the operated limb, with average loss of 27% flexion and 14% extension. The gracilis and sartorius muscles are not routinely used for pedicled reconstruction of the proximal tibia, nor would their harvest cause the symptoms of the patient described. The reversed sural artery flap is an adipofascial flap that could be used for this described defect; however, its dissection does not jeopardize the common peroneal nerve. The soleus muscle has better venous muscle pump function than the gastrocnemius, and edema, not nerve damage, is more common after use of the gastrocnemius. The limited data available suggest that the functional deficit with resulting limitation to ankle flexion is also more severe with soleus harvest.

Answer 142

The correct answer is option B. The anterior compartment is the most commonly affected compartment, usually secondary to tibial fracture. It contains the anterior tibial artery, deep peroneal nerve, tibialis anterior muscle, peroneus tertius, extensor hallucis longus, and extensor digitorum longus.

Answer 143

The correct response is Option E. The soleus muscle flap is most appropriate for reconstruction in this patient. The soleus is a bipenniform muscle; its medial head originates from the posterior tibia, and the lateral head originates from the proximal fibula. It is located deep to the gastrocnemius in the superficial posterior compartment. Blood to the medial head is predominantly supplied by the popliteal and posterior tibial arteries and the lateral head is predominantly supplied by the peroneal artery. Depending on the size of the defect, a hemisoleus muscle flap can be used to preserve flexor function. Below-knee amputation is an option if salvage of the leg is not possible or if the extremity is insensate, particularly in older patients. An anterior tibialis muscle flap can be used for small defects. In this patient with an absent dorsalis pedis pulse and possible injury to the anterior tibial artery, this is not an optimum choice. For lower-extremity reconstruction, the gastrocnemius muscle flap is used for knee wounds and proximal tibial defects, the soleus for middle third defects, and free tissue transfer for distal third defects. The gastrocnemius muscle flap might not reach the defect in the middle third and therefore is not the best option. Free tissue transfer is often used for reconstruction of high-velocity injuries to avoid the use of muscle in the zone of injury. Free tissue transfer, however, is not the best option for this 53-year-old man because his history of cigarette smoking and absent pedal pulse suggest the possibility of peripheral vascular disease.

Answer 144

The correct response is Option C. Antiplatelet therapy should be initiated to minimize the risk for flap loss in this patient. This patient has a reactive thrombocytosis which can commonly occur following trauma, infection, inflammation, or major surgery (e.g., post-splenectomy). This temporary elevation in platelet count is usually transient and peaks at approximately 2 weeks after injury. The traditional pharmacologic agents for microvascular thrombosis have minimal (e.g., aspirin) or no anti-platelet effects (e.g., heparin, hirudin, and thrombolytic agents). There are no guidelines or standards of care, but Hollenbeck et al. advocate for administration of glycoprotein IIb/IIIa antagonists (e.g., abciximab, tirofiban, and eptifibatide), which block the final common pathway for platelet aggregation. Thienopyridines (e.g., clopidogrel) often reach steady state after 4 to 7 days, which would further delay surgery. Platelet apheresis has also been described to reduce platelet count and secondary flap salvage. Acute trauma patients with elevated preoperative platelet counts are at higher risk for both intraoperative and postoperative microvascular complications (especially arterial thrombosis). Proceeding with free tissue transfer without any precautions is high risk for failure. A hematology consult and bone marrow biopsy is not necessary since the hypercoagulable state is usually self-limited but can take several weeks. This is not a chronic medical condition requiring further workup or treatment. Multiple studies suggest that patients with complex open fractures requiring soft-tissue coverage have improved outcomes with early free flap coverage, so it is not appropriate to wait until after this condition resolves. The platelet elevations can peak at approximately 2 weeks, which would delay reconstruction and increase morbidity. Delaying reconstruction increases the risks for infection, nonunion, and ultimately failure of limb salvage.

Answer 145

The correct response is Option D. An MRI should be performed in this patient to exclude a diagnosis of osteomyelitis. Although all of the imaging studies listed above will show abnormalities of bone, only a gadolinium-enhanced MRI will delineate the signal characteristics of bone marrow and specific enhancement pattern characteristic of osteomyelitis. Measurement of erythrocyte sedimentation rate is highly sensitive but nonspecific for osteomyelitis; this test is used instead as a follow-up for determining the efficacy of treatment in patients previously diagnosed with osteomyelitis. d to an advanced stage. High-resolution CT scans are inferior to MRI for diagnosis of osteomyelitis.

Answer 146

The correct response is Option A. This patient has a pressure sore from cast immobilization. He also has asymptomatic peripheral vascular disease, as is evidenced from his clinical examination. For the lower extremity to heal, adequate blood flow is required and this can be most effectively quantified with an ankle brachial index measurement. Ankle brachial index less than or equal to 0.9 establishes the presence of peripheral artery disease. Ankle brachial index between 0.5 and 0.79 yields wound healing issues and less than 0.5 results in rest pain and arterial insufficiency. CT angiography, MRI, MRA, and percutaneous angiography can assist in delineating anatomy but they do not yield clinically helpful information about perfusion, prognosis, or stratification of peripheral artery disease.

Answer 147

The correct response is Option B. Lower extremity fractures with combined soft-tissue and neurovascular trauma have high rates of complications, and a percentage of these injuries lead to amputation. Risk factors for amputation include Gustilo IIIC injuries, sciatic or tibial nerve injuries, prolonged ischemia (more than 4 to 6 hours), significant soft-tissue injury, significant wound contamination, multiple injured extremities, advanced age, lower versus upper extremity trauma, and futile attempt at revascularization. While tibial nerve injury is a risk factor and relative indication for amputation, it is never an absolute indication for amputation. Hard signs for vascular injury include: active hemorrhage, expanding hematoma, bruit or thrill, absent distal pulses, and distal ischemic signs and symptoms (five P’s). In the face of these hard signs, imaging such as CT angiography should be used to evaluate for vascular injury. With that said, most hard signs can be explained by soft-tissue or bone bleeding, traction of intact arteries due to unreduced fractures, or compartment syndrome. Early soft-tissue coverage is associated with a lower complication rate. The goal is to close wounds within 7 to 10 days to decrease the risk for infection, osteomyelitis, nonunion, and further tissue loss. It is best to get wound control prior to bone grafting, avoiding the risk of losing valuable limited bone; therefore, bone grafting is generally postponed until 8 to 10 weeks after soft-tissue wound coverage.

Answer 148

The correct response is Option E. Common peroneal nerve injuries involving motor function loss have been reported in up to 50% of knee dislocations. If isolated sensory disturbances are also included, the incidence of nerve injury approaches 75%. If no recovery is noted by 3 to 6 months following injury, then surgical treatment is warranted. Physical exam primarily determines the nerve to be explored, neurolysed, and possibly grafted, but nerve conduction studies can be useful pre- and intraoperatively. The common peroneal nerve divides into three branches at the knee, an articular branch that innervates the joint capsule and lateral collateral ligament of the knee, the superficial, and deep branches. The superficial branch innervates the muscles of the lateral compartment of the leg and provides sensation to the lateral calf and dorsal foot. The deep branch innervates the anterior compartment and provides sensation to the first web space of the foot. The scenario given above is most consistent with compromise of the superficial peroneal nerve. If dorsiflexion of the ankle and toe extension had also been lost, then common peroneal nerve injury would have been suggested. The posterior tibial nerve proper innervates the muscles of the posterior calf, mediating ankle plantar flexion and toe flexion. The medial and lateral plantar nerves are terminal branches of the posterior tibial nerve. They provide motor innervation to the deep plantar muscles of the foot and sensation to the plantar surface of the foot.

Answer 149

The correct response is Option B. The common peroneal nerve derives from the dorsal branches of the fourth and fifth lumbar and first and second sacral nerves. The common peroneal nerve lies between the biceps femoris and lateral head of the gastrocnemius muscle; it continues around the neck of the fibula between the peroneus longus muscle and the fibula, and then branches into the superficial fibular and deep fibular nerves. The common peroneal nerve innervates the peroneus longus, peroneus brevis, and biceps femoris muscle. Injury to this nerve results in a foot drop and sensory loss to the dorsal surface of the foot. The lateral sural nerve is a cutaneous nerve arising from the common fibular nerve. It supplies sensation to the posterior and lateral surfaces of the leg. This nerve does not supply motor innervation. The posterior tibial nerve, also known as the tibial nerve, is derived from L4, L5, S1, S2, and S3. It is a branch of the sciatic nerve. The nerve gives branches to the gastrocnemius, popliteus, and soleus muscles. Below the soleus muscle it supplies the tibialis posterior, the flexor digitorum longus, and the flexor hallucis longus muscles. The lateral plantar nerve is a branch of the tibial nerve. It supplies the quadratus plantae and the abductor digiti minimi muscles. Its sensory component supplies the skin of the fifth toe and the lateral half of the fourth toe. The lateral calcaneal nerve is a branch of the sural nerve supplying cutaneous sensation to the lateral aspect of the heel skin. This nerve is a cutaneous nerve with no muscle innervation.

Answer 150

The correct response is Option E. Thirty percent of diabetic patients have significant arterial calcifications in these arteries, which impedes blood pressure cuff compression, rendering the ankle-brachial pressure index inaccurate for ischemia. The ankle-arm index of 0.7 may thus be falsely elevated in this patient. Ordinarily, one would attempt to raise this index to at least 0.5 or 0.6 before performing soft-tissue reconstruction. Biphasic or triphasic arterial waveforms are usually consistent with sufficient vascularity for wound healing. Monophasic waveforms are associated more with extremity ischemia. However, even monophasic waveforms, as long as there is good amplitude and a narrow waveform complex, may be acceptable prior to attempting soft-tissue reconstruction. Digital vessels are frequently spared from calcification and absolute toe pressures are a better indicator of peripheral ischemia than ankle pressures. A toe pressure of less than 30 mmHg indicates ischemia and the need to obtain an angiogram with a view to prior vascular inflow improvement (such as angioplasty, stenting, or surgical reconstruction) before proceeding to soft-tissue reconstruction. Capillary refill time is a subjective clinical evaluation that is not as accurate or objective as pressure testing. Incomplete plantar arch communication between the dorsalis pedis and posterior tibial arterial systems is not an accurate indication for ischemia.

Answer 151

Correct Answer: E) Common peroneal nerve Rationale: Traumatic proximal tibiofibular dislocations frequently lead to injury of the common peroneal nerve, which courses around the fibular head, making it particularly susceptible to injury in these cases. Neurologic symptoms often include sensory deficits in the first dorsal webspace (innervated by the deep peroneal nerve) and foot drop due to weakness in dorsiflexion and toe extension. The other options are incorrect: • Tibial nerve: Responsible for plantarflexion and sensation to the sole of the foot; its injury would not result in first webspace anesthesia. • Sural nerve: Provides sensation to the lateral aspect of the foot and ankle, not the first webspace. • Saphenous nerve: A sensory nerve that supplies the medial aspect of the leg and ankle. • Sciatic nerve: Typically causes widespread motor and sensory deficits in the lower limb, rather than isolated first webspace anesthesia. Traumatic proximal tibiofibular fracture-dislocation injuries can be severe, sometimes needing immediate surgical intervention. Especially in cases with open fractures, vascular injury and compartment syndrome have been reported, with compartment syndrome being seen in 29% of cases in one study. Most larger case series also report variable rates of amputation, whether for a nonreconstructable limb, vascular injury, or nerve dysfunction. Common peroneal nerve injury is the most commonly reported nerve injury, sometimes involving greater than 35% of cases. As such, residual peroneal nerve deficits are the most common reason for later nerve reconstruction surgery. Posterior tibialis tendon transfer is a common option for common peroneal nerve dysfunction-related footdrop. 1. Herzog GA, Serrano-Riera R, Sagi HC. Traumatic proximal tibiofibular dislocation: a marker of severely traumatized extremities. J Orthop Trauma. 2015;29(10):456-459. doi:10.1097/ BOT.0000000000000348 2. Rajan PV, Ramski DE, Romeo NM. Traumatic dislocation of the proximal tibiofibular joint: a systematic review and 10-year experience from a level 1 trauma center. J Am Acad Orthop Surg Glob Res Rev. 2022;6(5):e21.00105. doi:10.5435/ JAAOSGlobal-D-21-00105 3. Krishnamurthy S, Ibrahim M. Tendon transfers in foot drop. Indian J Plast Surg. 2019;52(1):100-108. doi:10.1055/s-0039-1688105

Answer 152

The correct response is Option A. Nerve injury is a relatively rare but significant complication of varicose vein stripping. Knowledge of anatomy can help identify which nerve is involved in most injuries. Injury to the saphenous nerve would cause anesthesia over the medial calf and medial malleolus. Injury to the deep peroneal nerve would cause weakness in dorsiflexion and would result in increased insertional activity on electromyography of the tibialis anterior. Hypersensitivity on the dorsal foot or numbness over the lateral heel would come from an injury to the superficial peroneal nerve and the sural nerve, respectively.

Answer 153

The correct response is Option C. The absolute minimum compartment pressure measurements ranging from 25 to 50 mmHg are quoted as absolute indications for fasciotomy. The most frequently quoted absolute measurement is 30 mmHg.

Answer 154

The correct answer is option B. There is no difference in time to primary bone union or incidence of tibial non-union when comparing fasciocutaneous and muscle flaps. There is also no difference in time until return to ambulation and full weight bearing. Yazar 2006, Spfiadellis 2012, Paro 2016, Cho 2017 The correct answer is option B.

Answer 155

The correct response is Option D. The patient has a major vascular injury that is greater than 5.5 cm in length. A shark bite is considered contaminated and requires debridement. Because of the length of arterial injury, vein grafting is the most appropriate management option. End-to-end and end-to-side anastomoses are incorrect because the arterial defect is too long. The use of prosthetic material is incorrect because this is a contaminated wound, increasing the risk for infection.

Answer 156

The correct response is Option B. On the basis of the scenario described, fasciocutaneous free flap is the most appropriate management option. The soleus muscle flap is appropriate for defects of the middle third of the leg but lacks adequate reach for soft-tissue coverage of the distal third of the leg. Tissue expansion has been described for soft-tissue reconstruction of congenital talipes equinovarus but is usually reserved for children and in the setting of primary correction. When comparing tissue expansion in the limb versus non-limb sites, the incidence of complications associated with tissue expansion is significantly higher in the limb. Because a nonvascularized allograft is to be used, and the patient has a contracted and scarred soft-tissue envelope, tissue expansion would be associated with higher risk of expansion failure and complications when compared with free tissue transfer soft-tissue reconstruction. Cross-leg flaps are rarely used because of the availability of free tissue transfer. This flap is more appropriate in children than elderly patients, in whom stiffness is a factor. A reverse sural artery flap is not appropriate given the patient’s multiple past surgeries and local scars.

Answer 157

The correct response is Option E. Common peroneal nerve injury is common after posterior knee dislocation, usually occurring at or near where the nerve crosses the fibula neck. After surgical exploration to confirm the peroneal nerve is intact, initial management consists of supportive care with an ankle brace to correct foot drop. Patients are observed clinically for recovery, often with serial electromyography and nerve conduction studies. Tibialis posterior to anterior transfer will restore the patient’s ability to dorsiflex the ankle. The donor muscle is innervated by the tibial nerve, which is not commonly injured in a posterior knee dislocation. The tendon is dis-inserted from the tarsus and brought out through the medial leg. It is transferred through the interosseous membrane to the tibialis anterior tendon. By 18 months after injury, the motor end plates to the tibialis anterior have degenerated, making a nerve transfer no longer an option. Earlier after injury, a nerve transfer from the tibialis posterior to the tibialis anterior might be a feasible option. Peroneus longus and brevis would also be paralyzed in the setting of a common peroneal nerve injury such as this patient’s. In certain situations, such as with some patients with leprosy, the deep peroneal nerve is not paralyzed. For these patients, the peroneus longus can be used as a tendon transfer, but it is normally used to provide toe extension in conjunction with a tibialis posterior transfer to provide ankle dorsiflexion.

Answer 158

The correct response is Option C. The most appropriate management is immediate coverage of the exposed tibia using a filet-of-foot free flap. Free tissue from the amputated foot can be transferred to provide appropriate soft-tissue coverage without additional donor site morbidity. The dorsalis pedis artery and/or posterior tibial artery supply vascularity to the flap, and the tibial nerve provides sensory innervation. Above-knee amputation should be considered only as the last possible option. The energy required for ambulation in a patient with an above-knee amputation is much greater than in a patient with below-knee amputation. The reverse rectus femoris flap is not based on a distal pedicle; thus, it should not be used in a patient in whom knee extension must be preserved. A latissimus dorsi flap and split-thickness skin graft could be used for coverage if the amputated part were injured and unavailable as a donor site; however, in this patient there is no evidence of trauma distal to the lower third of the leg. Microvascular replantation cannot be performed in a patient who has sustained an avulsion amputation. In addition, bone shortening of greater than 10 cm would ultimately result in an abnormal gait.

Answer 159

The correct response is Option C. A free anterior lateral thigh flap is large enough to close the defect, can be thinned for aesthetics and shoe wear, and may allow for primary closure of the donor site. Although free tranverse rectus abdominus myocutaneous (TRAM) flap coverage is a possibility, the potential complications of taking muscle and unpredictable control of the final contour make them less ideal options. The reverse sural flap is not an option because of the ligation of the posterior tibial artery. In addition to having severe donor site morbidity, the dorsalis pedis would remove the remaining blood supply to the foot. The vascular nature of the defect’s wound bed makes bilaminate neodermis (Integra) and negative pressure wound therapy a less optimal choice.

Answer 160

The correct response is Option C. Most studies that demonstrate shoulder weakness and loss of motion show that the loss of function is greatest in the early postoperative period and returns to baseline, or close to baseline, at 1 year or more after surgery. All studies comparing types of latissimus flaps demonstrate less morbidity with perforator or muscle-sparing flaps as compared to traditional or extended latissimus dorsi (LD) flaps. Lower functional morbidity is observed with more native muscle preserved as is other flaps. This assumes that the muscular branches of the motor nerve to the latissimus are spared. A recent meta-analysis does show higher functional impairment than expected after latissimus flap transfer. The number of patients who required a change in occupation was less than 10%. This was likely because of difficulty with activities such as ladder climbing, painting overhead, and sustained reach overhead. The function of the latissimus dorsi muscle is shoulder adduction, extension and internal rotation. Other muscles of the rotator cuff perform similar functions and will assist in compensation for the loss of the latissimus. Patients who do develop weakness report it in activities involving shoulder adduction and internal rotation. Paradoxically, limitations in range of motion are mostly in shoulder flexion and abduction possibly related to tight skin closure and internal scarring. Donor site seroma formation is particularly problematic, with published rates ranging from 3.9 to 79%. Core muscles such as rectus abdominis, external oblique, gluteus maximus, medius, and minimus, and erector spinae all contribute to rotation, balance, and stabilization during sitting and standing.

Answer 161

The correct response is Option B. While anatomic variants in the vasculature of the leg are rare, failure to recognize these prior to sacrifice of the peroneal artery during harvest of a fibular free flap can result in disastrous ischemic complications. Variations occur more commonly in patients who have vascular insufficiency due to underlying atherosclerotic changes. In these patients, clinical examination alone is insufficient to adequately define blood flow patterns to the leg and foot. Color-flow Doppler imaging has demonstrated excellent ability to define the presence of flow-limiting lesions in the leg. Monophasic signals in any of the three major runoff vessels strongly suggest that the limb will be at risk for ischemia following sacrifice of the peroneal artery. Comparison of the findings on color-flow Doppler with angiography demonstrates that angiography is an unnecessary addition to the initial study. Angiography and CT angiography offer excellent road maps of the vasculature of the lower extremity, but each does involve the use of intravenous contrast. The dose of contrast used in CT angiography is significantly lower than that in traditional angiography, but neither would be justified in this patient with pre-existing renal insufficiency. MR angiography provides a map of the vessels comparable to both angiography and CT angiography without the use of nephrotoxic contrast agents. The additional information gained by seeing the vessels preoperatively (by MRA, CT angiography, or traditional angiography) may be justified when very long segments of the bone need to be harvested or when the perfusion to the overlying skin paddle may be better defined. Transcutaneous partial pressure of oxygen measures perfusion and does not offer any anatomic detail. The postoperative image shown demonstrates the free fibula reconstruction of the radius.

Answer 162

The correct response is Option E. The answer is tibial nerve. The sciatic nerve comes off the sacral plexus, then it branches into sural nerve, common peroneal nerve, and tibial nerve. The tibial nerve terminal branches are the medial sural cutaneous nerve, medial plantar nerve, and lateral plantar nerve. The medial plantar nerve innervates the abductor hallucis, flexor digitorum brevis, flexor hallucis brevis, and first lumbrical muscle. The cutaneous branches innervate the skin of the medial 2/3 of the sole of the foot as well as plantar digital toes. There are also terminal branches to the intertarsal and tarso-metatarsal joints. The flap is supplied by the medial plantar artery off the posterior tibial artery. The artery is found between the abductor hallucis and flexor digitorum brevis. It travels along the medial border of the foot and anastomosis with the first plantar metatarsal artery. Next, the perforators run between the abductor hallucis muscle and the plantar aponeurosis to the skin of the instep.

Answer 163

The correct response is Option A. The patient is presenting with extensive acute thrombotic occlusion resulting in clinically evident symptomatic venous insufficiency of the extremity. If the occlusion is left untreated, progressive cyanosis and secondary ischemia followed by gangrene develop. Locally delivered thrombolytic agents via catheter-directed thrombolysis with or without percutaneous transluminal angioplasty is an effective first line of treatment in this scenario where the patient presents within a few days of symptom onset (ie, prior to clot fibrosis) and is not high-risk for bleeding. In patients who are high-risk for bleeding (eg, acute intracerebral hemorrhage, gastrointestinal bleeding), alternative methods of restoring venous outflow include clot retrieval through other percutaneous or open techniques (eg, transluminal aspiration thrombectomy, open inferior vena cava (IVC) thrombectomy with or without temporizing groin arteriovenous fistula creation). Systemic thrombolysis can be considered when other first line therapies are not available but has been associated with high frequency of major bleeding complications in several randomized trials (14% for streptokinase). Systemic anticoagulation infusion helps prevent progression but does not restore acute compromised ischemic limb secondary to venous outflow obstruction. Oral anticoagulation is not indicated for acute management of a limb-threatening thrombosis. Femoral vein to IVC vascular bypass is not a described procedure for venous insufficiency. Limb-threatening thrombo-occlusive venous insufficiency resulting in a painful swollen blue leg, such as that pictured (also known as “phlegmasia cerulea dolens,” literally "painful blue edema") was first described with heparin-induced thrombocytopenia. It has also been associated with cancer or life-threatening critical illness. More recently, a growing population of patients are at risk due to unretrieved IVC filters. While IVC filter placement may protect the pulmonary vascular bed, it does not lessen thrombotic predisposition or incidence in the lower extremities, and IVC thrombosis with or without phlegmasia cerulea dolens has been reported to occur in 3 to 30% of patients following IVC filter placement. Filter retrieval following its initial indicated need can lessen secondary thrombotic complications, but data suggest that only a fraction of retrievable filters are later removed. In a systemic review, overall retrieval was 34% with a high percentage of nonretrieval occurring for a variety of reasons, including loss to follow up (particularly in trauma centers), limited life expectancy, and/or unresolved underlying conditions.

Answer 164

The correct response is Option D. This Gustilo IIIB wound is best covered with a free muscle flap. The latissimus muscle flap is an effective and frequently used flap for large wounds. This flap also has the advantage of large vessels and a long pedicle length. Dressing changes followed by a skin graft will not provide durable coverage over the tibia, is not appropriate in a healthy teenager who is not at surgical risk, and the time delay to coverage may predispose the patient to the development of osteomyelitis. A neuroadipofascial flap based on the vessels accompanying the sural nerve would be a poor choice, as this would be harvested from the zone of injury. The soleus flap is traditionally used for middle third defects of the leg and also is within the zone of injury. This is a salvageable extremity in a young teenager, which makes amputation inappropriate.

Answer 165

Correct answer is option E. Gustilo initially classified long-bone fractures into three types in order to establish a treatment algorithm. Essentially, this classification subdivided fractures according to the energy of the initial trauma that resulted in significant soft-tissue injury, periosteal stripping, and fracture comminution in the worst subtype. Debridement, antibiotics, and primary or delayed wound closure were advocated dependent on fracture severity. Type III fractures were subsequently subdivided into A, B, and C subtypes. Subtypes were stratified according to potential for complications such as infection, osteomyelitis, non-union, and amputation rates. Type IIIC had open fracture with arterial injury requiring repair (the case in this patient, even though there appears to be adequate soft-tissue coverage). Although fracture fixation methods have substantially improved since the original publications of Gustilo, the ability to transport bone into segmental traumatic defects has also since developed, and free flaps have extended our ability to cover large wounds. This classification system has stood the test of time and still forms the basis of prognosticating and determining the optimum treatment algorithm. The Gustilo grading scale: Type Findings I Clean wound bed, simple/minimally comminuted bone injury, wound <1 cm II Wound contaminated, moderate comminution of bone, wound >1 cm IIIA Wound highly contaminated, severe comminution, wound 1 to 10 cm IIIB Wound highly contaminated, severe comminution, wound >10 cm IIIC Major vascular injury requiring repair for limb salvage

Answer 166

The correct response is Option A. The Gustillo-Anderson classification system is used to grade open fractures based on the extent of bone and soft tissue injury, and the extent and nature of wound contamination. Aggressive debridement, administration of prophylactic antibiotics, application negative pressure dressing while the wound is open, and early definitive wound coverage (less than 5 days) reduces the infection risk. The open fracture described is a grade II injury and a first-generation cephalosporin alone provides appropriate antibiotic coverage. A concurrent vascular or neural injury or gross contamination could escalate this into a grade III injury, but there is no mention of these factors in the clinical scenario described.

Answer 167

The correct response is Option C. Sensory neuropathy leads to loss of protective sensations. This then leads to neuropathic imbalance with loss of coordination which increases mechanical stresses, unperceived trauma, Charcot foot, and ulcers. Sympathetic neuropathy leads to warm, dry feet which are prone to skin breakdowns. Patients with diabetes who also have peripheral vascular disease are more prone to ischemic ulcers. Patients with diabetic foot ulcers have not been associated with large-vessel atherosclerosis.

Answer 168

The correct response is Option A. The common peroneal nerve forms as the sciatic nerve bifurcates at the apex of the popliteal fossa. It then follows the medial border of the biceps femoris muscle and tendon. The nerve then passes over the posterior aspect of the fibular head and winds around the neck of the fibula. The common peroneal then divides into the deep and superficial peroneal nerve branches. The deep branch supplies the anterior muscles of the leg, the dorsum of the foot, and the skin of the first web space. The superficial branch supplies the peroneus longus and brevis muscles and the skin on the distal third of the lower leg and dorsum of the foot. Because of its relatively superficial position, the common peroneal nerve is the most commonly injured nerve of the lower extremity. Transection of the common peroneal nerve results in paralysis of all muscles in the anterior and lateral compartments of the leg (dorsiflexors and ankle evertors). This pattern of injury results in the classic picture of a foot drop. The distribution of sensory loss would include the anterolateral leg and dorsum of the foot. Sensation of the medial foot is from the saphenous nerve and branches of the medial plantar nerve. Lateral foot sensation is provided by the sural nerve. Sensation of the plantar aspect of the foot is from the terminal branches of the tibial nerve (medial and lateral plantar nerves). All of the muscles of plantar flexion of the ankle and toes (i.e. gastrocnemius, soleus, plantaris, and tibialis posterior, flexor hallucis longus, flexor digitorum longus, and the intrinsic plantar foot muscles) are innervated by the tibial nerve.

Answer 169

The correct response is Option C. Lower extremity open fractures are described using the Gustilo classification. The patient in this scenario has a Gustilo IIIB: extensive soft tissue avulsion or degloving, from high velocity injury and gross contamination. The best treatment for such injuries is intraoperative debridement and washout with early or immediate fracture stabilization, often with an external fixator. Immediate soft-tissue reconstruction is not done due to the high-energy mechanism and gross contamination. This mandates repeat evaluation to assure all nonviable tissue and foreign material are removed prior to reconstruction. Definitive and stable soft-tissue reconstruction should be done as soon as possible and is classically thought to be best when provided within 72 hours of injury. Soft-tissue reconstruction done as quickly as possible reduces the risk of nonunion and osteomyelitis. In the proximal third of the leg, the gastrocnemius flap is indicated, while the soleus flap is for the middle third. Most often, free tissue transfer is the best option for the distal third wounds. Cross-leg flap is seldom used because of the prolonged immobilization that is required. Delayed reconstruction beyond the one week window is sometimes necessary because of other confounding factors in a multiple-trauma patient. In such situations, preventing desiccation of the bone is necessary, for which negative pressure wound therapy is useful. Soft tissue reconstruction is then accomplished when feasible with preference for flap reconstruction.

Answer 170

The correct response is Option E. When multiple tendon grafts are needed or when it is necessary to harvest grafts long enough to reach from the forearm to the fingertip, lower extremity tendon graft harvest is necessary. The plantaris tendon is a good source of tendon graft and is present in about 80% of limbs. The graft is harvested through a vertical incision just anterior to the medial aspect of the Achilles tendon. Then the graft is followed proximally using either a tendon stripper or with further incisions. As such, dissection of the plantaris tendon begins behind the medial malleolus and close to the tibial nerve. The sural nerve lies about the lateral malleolus and thus is not likely to be inadvertently injured during plantaris harvest. The medial plantar artery is on the sole of the foot and would be distal to the field of dissection. The extensor hallucis brevis muscle is a small muscle that lies over the dorsum of the foot and thus, like the dorsalis pedis artery, would not be injured in the dissection.

Answer 171

The correct answer is option B. Compared with a conventional nonvascularized autograft, a vascularized fibula graft has increased osteocyte viability. In one study, osteocyte counts in the cortex of vascularized grafts were 89% of those observed in normal control subjects. There were substantially fewer surviving osteocytes in conventional grafts. Nonvascularized bone autograft incorporation occurs by creeping substitution, which involves gradual vascular ingrowth, resorption, and replacement of necrotic bone. The revascularization process that occurs causes significant mechanical weakening due to bone resorption at six to 12 months. Vascularized bone grafts allow living bone tissue to be transplanted to an adjacent or remote location. They have been used in segmental bone defects larger than 6 cm due to tumor, trauma, osteomyelitis, or infected nonunion. Other indications include avascular necrosis of bone, composite tissue loss requiring complex reconstruction, and longitudinal growth with physeal transfer. The transfer of vascularized bone grafts increases cell survival and as a result the process of bone graft incorporation by creeping substitution is obviated. Significant osteopenia is not seen and bone mass is maintained after transfer. The result is improved strength, healing, and stress response. Cell survival results in less remodeling during revascularization.

Answer 172

The correct answer is option E. For lower extremity reconstruction in trauma patients, multiple studies comparing fasciocutaneous free flaps and muscle free flaps have shown no difference in flap thrombosis or flap loss, limb salvage, infection, bone healing, and functional recovery. Both types of flaps also undergo similar rates of secondary revisions. Yazar 2004, Cho 2017 The correct answer is option E.

Answer 173

The correct response is Option C. The flap used to cover the Achilles tendon in the patient described is the reverse sural fasciocutaneous flap. It is based on perforators from the peroneal artery through a network of small vessels. The general axis of the flap follows the sural nerve from behind the lateral malleolus to the mid portion of the gastrocnemius muscle bellies. Sural nerve injury results in loss of lateral foot sensation. This is often of no functional consequence because its harvest does not result in loss of a major neurovascular structure. The other vessels noted do not supply inflow to the flap.

Answer 174

The correct response is Option B. In a patient who has a 12-cm bone defect, the most appropriate management is reconstruction using a well-vascularized, uninjured segment of bone graft, such as a contralateral free vascularized fibula graft. The contralateral fibula will provide more than 20 cm of bony length. Neither allograft nor nonvascularized autograft would provide the required bone length for revascularization. For this reason, nonvascularized bone graft is also not appropriate. Vascularized iliac crest graft can be used for reconstruction in the upper and lower extremities but would not provide a large enough segment of bone graft. Because of this patient's injuries, the ipsilateral fibula should not be used. In addition, harvest of an ipsilateral bone graft would remove the ipsilateral supplemental support.

Answer 175

The correct response is Option A. This patient has a pressure sore from cast immobilization. He also has asymptomatic peripheral vascular disease, as is evidenced from his clinical examination. For the lower extremity to heal, adequate blood flow is required and this can be most effectively quantified with an ankle brachial index measurement. Ankle brachial index less than or equal to 0.9 establishes the presence of peripheral artery disease. Ankle brachial index between 0.5 and 0.79 yields wound healing issues and less than 0.5 results in rest pain and arterial insufficiency. CT angiography, MRI, MRA, and percutaneous angiography can assist in delineating anatomy but they do not yield clinically helpful information about perfusion, prognosis, or stratification of peripheral artery disease.

Answer 176

The correct response is Option E. The predominant blood supply to the reverse sural artery flap relies on perforators from the peroneal artery, which primarily originate at a point 5 cm proximal to the lateral malleolus. The median superficial sural artery and perforators from the gastrocnemius are involved in anterograde blood supply to the flap. Thus, these vessels are typically ligated in the reverse form of the flap. Likewise, injury to the lesser saphenous vein would not cause significant problems with venous outflow. In dissections and venous flow studies, small concomitant veins were found along both sides of the lesser saphenous vein and were considered to be venae comitantes of accompanying arteries of the vein. These accompanying veins played a role in bypassing the valves of the lesser saphenous vein. The sural artery flap can be harvested as a neural-veno-adipofascial flap. In this context, the sural nerve can used to provide sensation to the flap. This nerve does not provide primary blood supply to the flap, and injury would not compromise flap viability.

Answer 177

The correct response is Option B. The symptoms and findings of severe pain at rest, ulceration, and gangrene seen in this patient are indicative of limb ischemia, a critically urgent condition that results from occlusion of the pedal and crural arteries. Although amputation had been performed in the past for patients with this condition, distal venous arterialization bypass is now a recommended alternative method for limb salvage. According to one small study of 18 patients, limb salvage was successfully accomplished in 83% of patients at surgery and 75% of patients at follow-up examination one year later. In these patients, the distal bypass was performed to the venous vessels of the foot using a conduit of either vein, synthetic graft, or a combination of both. The valves of the venous system were destroyed, and arterial inflow was then provided by the most distal patent artery. Because both the pedal and crural arteries are occluded in this patient, neither direct arterial bypass nor placement of an endovascular stent will address the problem. Both free muscle transfer and lumbar sympathectomy are associated with lower rates of limb salvage in patients with severe ischemia.

Answer 178

The correct response is Option B. Though it was never designed to predict treatment, the Gustilo classification has stood the test of time as a highly utilized grading system for lower extremity trauma. It is often used to predict the need for flap coverage, to estimate the risk for osteomyelitis, and to guide antibiotic use.

Answer 179

The correct response is Option C. The patient described has a limb amputation that includes a significant avulsion component, exemplified in the long tendon stumps that appear ripped off from their muscle bellies, and ankle disarticulation. Avulsion amputations of the lower extremity are not suitable for replantation because of the extended neurovascular damage that is present on both ends well beyond the level of the injury. The incidence of thrombosis at the anastomosis is high. Use of vein grafts on a free flap could be considered, but, in this case, they may have to be connected as high as knee level to ensure patency. The amputated part likely has massive microscopic endothelial damage extending to terminal vessels and could only be used as a donor site for skin grafts. Therefore, there is no role for immediate or delayed replantation. While preservation of maximum tibial length is desirable in preparing the amputation stump, prosthetic fitting for ankle disarticulations is fraught with trouble. Some tibial shortening is required to have a comfortable, reliable prosthesis. In the scenario described, tibial shortening of 2 and 4 in would have equivalent results because there is still ample length of proximal tibia available to provide the same functionality and equivalent energy expenditure. Therefore, use of a free flap to protect an additional 2 in of tibia adds no advantage for this patient. When the level of amputation is through the proximal tibia, some benefit could be found in that a minimum of 6 in of proximal tibia is available for prosthetic fitting. Split-skin grafts are generally unstable in weight-bearing surfaces and take longer to heal and mature, which causes delay in rehabilitation. Skin grafts will not take or perform well when applied over an articular surface.

Answer 180

The correct answer is option B. aortobifemoral bypass- this is characteristic of Leriche syndrome: buttock claudication, impotence, and loss of femoral pulses. Aortobifemoral bypass is the mainstay of treatment. Axillobifemoral bypass with crossover is a secondary option in patients with hostile abdomen or high operative risk. The other options will not restore blood flow.

Answer 181

The correct response is Option E. The most appropriate management of this wound is serial debridement and delayed closure. With such a high level of contamination of both the soft and hard tissues, layered closure after the initial debridement will very likely lead to infection, especially in a patient with a history of smoking. It would be a mistake to perform a free tissue transfer in a highly contaminated wound. Furthermore, there is no missing or ischemic tissue. Negative pressure wound therapy followed by skin grafting would not be appropriate for a deep wound with bone exposure when local tissues are available for closure; this would be more appropriate for a superficial wound with missing skin. Healing by secondary intention is an option; however, serial debridement and delayed closure will take less time, is less painful, and avoids scar formation in the heel.

Answer 182

The correct response is Option A. The appropriate reconstructive option from the given choices for this patient would be bipedicled advancement flap. It is important to understand the blood supply to local skin flaps. The bipedicled advancement flap is a random pattern flap with perfusion from the dermal/subdermal plexus. Unlike a standard, single-pedicle random pattern flap, the bipedicled flap maintains skin connections in two directions allowing for a 2:1 length-to-width ratio. The donor defect of the bipedicled flap is typically skin grafted to minimize opposing tension on the flap and allow for greater advancement. The wide subcutaneous undermining 7 days prior would have allowed for the "delay phenomenon," potentially making the flap more reliable. The extensive wide subcutaneous undermining during initial primary closure likely injured perforators to the skin. The V-Y advancement flap is typically islandized during closure and would be compromised by adjacent wide undermining. Similarly, a keystone flap would be compromised if the skin was delaminated from the underlying tissues. An adjacent perforator flap is perfused by a cutaneous perforator (septocutaneous or muscular) which likely would have been injured during wide undermining. Split-thickness skin graft is not appropriate because there is no peritenon on the tendon. A Mustardé rotational flap is used for cheek advancement.

Answer 183

The correct response is Option C. The patient appears to demonstrate symptoms of a superficial peroneal nerve injury. The superficial peroneal nerve arises from the common peroneal nerve at the fibular neck. It supplies the lateral compartment of the leg, giving motor branches to peroneus longus and brevis, as well as sensory contribution to the lateral aspect of the leg. Injury to the superficial peroneal nerve results in anesthesia of the lateral aspect of the leg and weakness in eversion and plantar flexion of the foot. The deep peroneal nerve arises from the common peroneal nerve at the fibular neck. It travels in the anterior compartment of the leg and gives branches to the tibialis anterior, extensor hallucis longus, and extensor digitorum longus and brevis, as well as peroneus tertius. The sensory distribution is in the area of the first web space. Injury to the deep peroneal nerve causes weakness in dorsiflexion of the foot. The femoral nerve innervates muscles of the anterior thigh, including the quadriceps group, iliacus, and sartorius. Injury to the femoral nerve results in weakness of leg extension. The obturator nerve provides innervation to the medial thigh muscles (adductor group), including adductor brevis, longus, and magnus, as well as the gracilis and obturator externus. The cutaneous branch provides sensation of the medial thigh. Injury to the obturator nerve results in weakness in thigh adduction and sensory deficits in the medial thigh. The sural nerve travels on the posterior aspect of the leg between the lateral malleolus and calcaneus. It provides sensation to the lateral aspect of the foot and does not have a motor component. It is commonly sampled in nerve biopsy and used as a source of nerve graft. Injury or sacrifice of the sural nerve would result in numbness of the lateral foot. The tibial nerve is a branch of the sciatic nerve. It travels through the popliteal fossa and gives off branches to gastrocnemius, soleus, plantaris, and popliteus muscles. The tibial nerve travels in proximity to the posterior tibial artery. In the leg, it gives off branches to the flexor digitorum longus, tibialis posterior, and flexor hallucis longus. Distally in the foot, it branches to give rise to the medial and lateral plantar nerves, which provide sensation to the plantar surface of the foot. Injury to the tibial nerve results in deficits of plantar flexion, as well as anesthesia to the plantar surface of the foot.

Answer 184

The correct response is Option C. The gastrocnemius flap is the primary flap used to cover soft-tissue defects of the upper third of the tibia and knee. The gastrocnemius muscle is a bipennate muscle located on the posterior surface of the lower leg. The muscle originates from the medial and lateral condyles of the femur and inserts into the Achilles tendon. The dominant blood supply of the muscle is the medial and lateral sural arteries, which are branches of the popliteal artery. Generally only one head of the gastrocnemius flap is harvested to cover soft-tissue defects. The muscle alone is generally taken and is covered with a split-thickness skin graft for lower extremity reconstructions. The geniculate arteries primarily supply the bone around the knee joint.

Answer 185

The correct response is Option E. The best treatment that would allow salvage of the fracture fixation is operative debridement and vascularized flap reconstruction. Stable fixation has been achieved and subacute wound dehiscence has occurred because of ischemia or devitalization of the overlying soft tissue. This is due to the forces of the original trauma as well as potential further traumatic insult of the tissue during surgical repair. In the absence of infection, immediate soft-tissue reconstruction will provide stable vascularized soft-tissue coverage of the fracture site and the hardware. As such, vascularized flap reconstruction is appropriate. In the distal leg, this often requires free tissue transfer, but depending on the location and size of the defect, soleus flap or perforator propeller flaps can be used. Gustilo provided a classification of open fractures of the leg in which the fracture site was exposed through a disruption of soft-tissue integrity: Determination of the type of flap reconstruction required requires assessment of not only the location and size of the defect, but also the zone of injury. Greater degrees of force are associated with the increasing Gustilo classification such that type III fractures often require free tissue transfer because of concomitant damage of the regional and local tissues. Operative debridement and placement of a VAC for a bridge to skin grafting is a potential treatment for an open wound with exposed bone without hardware. The period of time in which the wound remains open and granulates during this process provides a very high risk for hardware infection, nonunion, and osteomyelitis. Debridement with skin advancement and closure is likely to fail because of the difficulty in providing appropriate tension-free advancement flaps in the leg, combined with the need to accommodate for tissue loss from the debridement and ischemia of the advancing skin edges. The reliability of this treatment is poor and would have high risk for failure and subsequent hardware infection and nonunion or osteomyelitis. Hardware removal, casting, and wound care is not indicated since the fracture repair is intact and no signs of infection are present. However, if hardware removal were required because of overt infection, the most appropriate treatment would be placement of an external fixator and soft-tissue flap reconstruction. Hyperbaric oxygen and wound care is not the best option in this acute situation in which prompt soft-tissue reconstruction and vascularized coverage of the fracture site are required to salvage the existent fixation and avoid mal/nonunion or osteomyelitis.

Answer 186

The correct response is Option E. The medial plantar artery flap, or instep flap, provides sensate, full-thickness glabrous skin and subcutaneous tissue that can be transferred as a pedicled or free flap. The tissue is well suited for weight-bearing areas of the foot but has also been used as a free tissue transfer for palmar defects. Because the instep donor site is non–weight-bearing, the donor site can be covered with a skin graft. The innervation of the medial instep flap comes from the medial plantar nerve, a branch of the tibial nerve.

Answer 187

The correct response is Option B. This patient has early wound dehiscence after undergoing open reduction and internal fixation of a lateral malleolus fracture. Appropriate management involves early coverage of the exposed bone and hardware to promote bony union while preventing bacterial colonization of the hardware, which may lead to the development of osteomyelitis. Because this patient underwent open reduction and internal fixation only two weeks ago, fixation is still required to maintain rigid fracture stabilization. Instead, coverage with a free flap is recommended to provide stability and vascularity and to enhance function once bony union is obtained. Skin grafting will not provide stable, well vascularized coverage in this patient. External fixation is problematic because of the location of the fracture. Removal of the hardware two weeks after fracture is indicated only for established hardware failure.

Answer 188

The correct response is Option E. The superficial circumflex iliac and superficial femoral arteries provide vascularity to the sartorius muscle flap. The superficial circumflex iliac artery is a branch of the external iliac artery; it courses laterally to provide the primary blood supply to the groin flap and the proximal part of the sartorius muscle. The external iliac artery then continues as the common femoral artery and branches into the profunda femoris and superficial femoral arteries at a point distal to the inguinal ligament. The superficial femoral artery travels distally in the thigh and gives off segmental branches to the sartorius muscle. Because the groin is one of the most common areas of graft exposure, the sartorius muscle can be used to cover small defects. This muscle can be detached from its proximal origin on the iliac crest and turned over to cover groin wounds. Other options for coverage in this region include the gracilis, rectus femoris, vastus lateralis, tensor fascia lata, and rectus abdominis muscles. The lateral femoral circumflex artery, which is a branch of the profunda femoris artery, supplies blood to the rectus femoris, tensor fascia latae, and vastus lateralis muscles. The medial circumflex femoral artery is a branch of the profunda femoris artery. This vessel provides the blood supply to the gracilis muscle.

Answer 189

The correct response is Option A. The flexor hallucis longus flexes the great toe and is located in the deep posterior compartment. The soleus and plantaris muscles are located in the superficial posterior compartment, just deep to the gastrocnemius muscles. The peroneus brevis is located in the lateral compartment. The tibialis anterior is located in the anterior compartment.

Answer 190

The correct response is Option E. The most appropriate next step when evaluating the arterial perfusion of this diabetic patient’s foot is obtaining a toe-brachial index (TBI). TBI is calculated by dividing the great toe systolic pressure by the brachial systolic pressure. An index of \>0.7 is considered normal. Patients with diabetes mellitus have a higher incidence of peripheral arterial disease than the non-diabetic population. Atherosclerotic lesions in diabetic patients tend to favor the arteries below the knee, which also commonly display medial calcinosis, causing stiffening of the arterial walls, poor compressibility, and an unreliably high ankle-brachial index (ABI). Interestingly, the small vessels of the great toes are usually spared of disease, therefore the diagnostic advantage of TBIs. These features should be taken into consideration whenever assessing arterial blood flow to the distal lower extremity of a diabetic patient. Percutaneous arteriography is an invasive procedure and should be reserved for when surgical or endovascular therapeutic interventions are anticipated. Computed tomography arteriography and magnetic resonance arteriography may also be used in the diagnosis of peripheral artery disease in the lower extremities, but a normal TBI would most likely preclude their need. Repeating the ABI would most likely render a similar result, as the inability to compress the arteries in the leg is due to stiffened vessel walls.

Answer 191

The correct response is Option E. The most appropriate initial step for fracture stabilization is placement of an external fixation device. The patient described will require multiple debridements for the heavy contamination, followed by a free muscle flap to provide soft-tissue coverage of the exposed tibia fracture, and a future avascular bone graft for the 4-cm segmental bone loss. Intramedullary rod stabilization for the initial management of open fractures of the tibia has gained increasing popularity in the orthopaedic literature, but the bone fixation is converted from external fixation to an intramedullary rod within the first 10 days of injury immediately prior to muscle flap coverage. Although reported in the literature, the use of the ipsilateral fibula has been criticized, especially in trauma cases, because of (1) the loss of the mechanical integrity of the limb, which is especially useful to maintain limb length; (2) the loss of the peroneal artery in a traumatized limb; and (3) the loss of the origins of the deep muscles, which contributes an additional 30% loss of strength in an already traumatized and weakened extremity. A 4-cm segmental bone loss does not require vascularized bone by either a pedicled or free bone flap. Plate stabilization of the tibia fracture described is not indicated because of the heavy contamination and the soft-tissue loss. Also, avascular bone grafts are not recommended in the initial management of open lower extremity wounds because of the risk of graft loss secondary to infection. An antibiotic-impregnated spacer could be used to help prevent infection, but it is not the initial step for fracture stabilization.

Answer 192

The correct response is Option C. An adequate perforator is not found on dissection of the anterolateral thigh (ALT) free flap in up to 5% of cases. When an ALT flap perforator traveling between the rectus femoris and vastus lateralis or through the vastus lateralis to supply the anterolateral thigh skin is not found, there is a higher chance of finding a perforator that supplies the anteromedial thigh skin. This perforator, present in about 50% of thighs, most commonly arises from the descending branch of the lateral circumflex femoral artery, via a branch that supplies the rectus femoris muscle. This perforator can take a course through the rectus femoris or between the rectus femoris and vastus medialis. Alternately, one or more anteromedial thigh perforators may arise directly from the superficial femoral artery. When an ALT perforator cannot be located, the surgeon may salvage the situation by changing to an anteromedial thigh (AMT) free flap rather than exploring another donor site. Another alternative is to harvest a tensor fascial lata free flap, based on the ascending branch of the lateral circumflex femoral artery. The medial circumflex femoral artery, common femoral artery, and profunda femoris artery do not give rise to previously described cutaneous perforator flaps.

Answer 193

The correct response is Option D. Anatomic dissections by Drs. Grabb and Argenta found that the lateral calcaneal artery is usually the terminal branch of the peroneal artery but occasionally may arise from the posterior tibial artery. The branches of the peroneal include the nutrient artery which supplies the fibula, the perforating branch which gives branches to the tarsus, the communicating branch and the lateral calcaneal.

Answer 194

The correct response is Option C. The patient appears to demonstrate symptoms of a superficial peroneal nerve injury. The superficial peroneal nerve arises from the common peroneal nerve at the fibular neck. It supplies the lateral compartment of the leg, giving motor branches to peroneus longus and brevis, as well as sensory contribution to the lateral aspect of the leg. Injury to the superficial peroneal nerve results in anesthesia of the lateral aspect of the leg and weakness in eversion and plantar flexion of the foot. The deep peroneal nerve arises from the common peroneal nerve at the fibular neck. It travels in the anterior compartment of the leg and gives branches to the tibialis anterior, extensor hallucis longus, and extensor digitorum longus and brevis, as well as peroneus tertius. The sensory distribution is in the area of the first web space. Injury to the deep peroneal nerve causes weakness in dorsiflexion of the foot. The femoral nerve innervates muscles of the anterior thigh, including the quadriceps group, iliacus, and sartorius. Injury to the femoral nerve results in weakness of leg extension. The obturator nerve provides innervation to the medial thigh muscles (adductor group), including adductor brevis, longus, and magnus, as well as the gracilis and obturator externus. The cutaneous branch provides sensation of the medial thigh. Injury to the obturator nerve results in weakness in thigh adduction and sensory deficits in the medial thigh. The sural nerve travels on the posterior aspect of the leg between the lateral malleolus and calcaneus. It provides sensation to the lateral aspect of the foot and does not have a motor component. It is commonly sampled in nerve biopsy and used as a source of nerve graft. Injury or sacrifice of the sural nerve would result in numbness of the lateral foot. The tibial nerve is a branch of the sciatic nerve. It travels through the popliteal fossa and gives off branches to gastrocnemius, soleus, plantaris, and popliteus muscles. The tibial nerve travels in proximity to the posterior tibial artery. In the leg, it gives off branches to the flexor digitorum longus, tibialis posterior, and flexor hallucis longus. Distally in the foot, it branches to give rise to the medial and lateral plantar nerves, which provide sensation to the plantar surface of the foot. Injury to the tibial nerve results in deficits of plantar flexion, as well as anesthesia to the plantar surface of the foot.

Lower Extremity Flashcards

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