Monobactams

Question 1

What is a Monobactam?

Answer 1

Unique class of beta-lactams with a four-membered ring lacking a fifth or sixth member, like other beta-lactams

Question 2

Only available agent of Monobactams

Answer 2

Aztreonam (Azactam)

Question 3

Monobactams Distribution

Answer 3

distribute well into most tissues; not extensively bound to proteins

Question 4

Monobactams Half life

Answer 4

3 hours

Question 5

Monobactams Elimination

Answer 5

excreted primarily unchanged by glomerular filtration

Question 6

Monobactams Mechanism of Action

Answer 6

interfere with bacterial cell wall synthesis; safe toxicity profile.

Question 7

Monobactams Clinical Uses

Answer 7

treating urinary tract infections (UTIs) and respiratory tract infections.