Movement disorders CPC

Question 1

List major classes of degenerative disorders

Answer 1

1. dementing diseases
2. movement disorders
3. motor neuron disease

Question 2

list dementing diseases

Answer 2

1. Alzheimer’s Disease
2. Lewy Body Disease Spectrum (LBD)
3. Frontotemporal Dementia (FTD)

Question 3

List movement disorders

Answer 3

1. Parkinson’s disease
2. Multiple systems atrophy (MSA)
3. Progressive Supranuclear Palsy (PSP)
4. Huntington’s disease
5. Spinocerebellar ataxias

Question 4

List motor neurons diseases

Answer 4

1. Spinal muscular atrophy (SMA)
2. Amyotrophic lateral sclerosis (ALS)
3. Primary lateral sclerosis (PLS)

Question 5

dementing disease signs

Answer 5

1. Impaired language
2. Impaired long term memory
3. Impaired planning, behavior, judgment, executive control
4. Impaired short term memory

Question 6

Movement disorder categories

Answer 6

1. basal ganglia disorder

2. cerebellar disorders (HANDS Tremor)

Question 7

Basal ganglia disorder signs

Answer 7

1. Tremor (usually resting)
2. Hypokinesis
3. Hyperkinesis

Question 8

Hypokinesis:

Answer 8

bradykinesis and rigidity

Question 9

Hyperkinesis:

Answer 9

1. chorea
2. athetosis (involuntary writhing movements)
3. akathisia (restlessness)

Question 10

Cerebellar disorders (HANDS Tremor) signs

Answer 10

1. Hypotonia
2. Ataxia/Asynergia
3. Nystagmus
4. Dysarthria
5. Stance and gait disequilibrium
6. Tremor (usually intention)

Question 11

Overlap of Progressive Supranuclear Palsy

Answer 11

tauopathy that manifests as a movement disorder

Question 12

Overlap of AD

Answer 12

tauopathy that manifests as dementing diseases

Question 13

List synucleinopathies

Answer 13

1. parkinson’s disease

2. Multiple system atrophy

Question 14

Parkinson’s disease histology hallmarks

Answer 14

1. Lewy bodies
2. Lewy neuritis (proteinacious structures around neurons)
3. Substantia nigra degeneration (with few neurons and gliosis)

Question 15

Multiple system atrophy

histology hallmarks

Answer 15

1. Glial cytoplasmic inclusions (inclusions are synuclein protein)
2. Gliosis and glial scars
3. Neuronal inclusions
4. Diffuse involvement/degeneration of brainstem, putamen, white matter, and cerebellum

Question 16

various disease processes affecting specific neuroanatomic site manifest ______

Answer 16

similar symptoms.

Question 17

damage to the substantia nigra can cause

Answer 17

1. parkinson’s disease
2. multiple system atrophy
3. progressive supranuclear palsy
4. corticobasal degneration

All present with parkinsonian-like symptoms

Question 18

What is the role the frontal lobes in human cognition?

Answer 18

1. Voluntary movement
2. Language production (left)
3. Motor prosody - inflection of speech, homologous area on right side
4. Comportment
5. Executive Function/ understand emotions of others

Question 19

What is the role the temporal lobe in human cognition?

Answer 19

1. Audition
2. Language comprehension
3. Sensory prosody - understanding inflection, located on right side
4. Memory
   - -Hippocampus - remember H.M. removal of bilateral hippocampi for intractable epilepsy
5. Emotion
   - -Limbic system and Papaz circuit

Question 20

What is the role the parietal lobes in human cognition?

Answer 20

1. Tactile sensation
2. Visuospatial function
3. Attention ( R )
4. Reading (L)
5. Writing (L)
6. Calculation (L)

Question 21

What is the role the occipital lobes in human cognition?

Answer 21

1. Vision
2. Visual Perception
3. Visual Recognition