What is a synapse?
The gap between 2 neurons
Function of a synapse
To transfer impulses across neurons
Steps of a synapse functioning
An action potential arrive at the presynaptic knob.
Ca+ ion channels open and ions diffuse into the presynaptic knob.
Vescicules containing neurotransmitters fused with presynaptic membrane. Causing neurotransmitters to be released into the synapse.
Neurotransmitters diffuse down conc gradient across cleft towards postsynaptic neuron.
Neurotransmitters bind to receptors which have a complimentary structure.
Na+ ion channels on post-synaptic membrane open and so ions diffuse in. Above threshold, an action potential is triggered.
Neurotransmitters degrae and released from receptors. Channels close and resting potential restored.
Why is the impulse / neurotransmitter unidirectional?
Neurotransmitters and vesicules found in the presynaptic knob.
Receptors only on postsynamptic membrane.
Neurotrasmitter and enzyme in cholergenic synapse
Neurotransmitter - Acetylcholine
Enzyme - Acetylcholine esterase
What is summation?
Build up of transmitters in the synapse to help generate an action potential.
Why is summation required sometimes?
Some action potentials do not result in a sufficient concenrtations of neurotransmiteers for a sufficient opening of Na channels for an action potential to be triggered.
Spatial summation
Many different presynaptic neurones collectively trigger a new action potential by combining neurotransmitters they release to exceed threshold on a postsynaptic.
Temporal summation
One neurone releases neurotransmitter repeatedly over a short period of time to add up to enough to exceed the threshold.
What is an inhibitory synapse?
A realising of neurotransmitter which makes the postsynaptic membrane less likely to trigger an action potential.
How does inhibtory synapse reduce action potentials?
Hyperpolarisation.
Membrane is more negative and below resting potential so needs more sodium ions for an action potential.
Where are synapses located?
At the end of axons
Process of inhibitory synapse
Neurotransmitters bind to Cl- ion channels causing them to open and move into the postsynaptic neurone.
K+ channels open and K+ move into the postsynaptic neurone.
Differences between cholergic and neuromuscular synapses
Neurone to neurone/effecter vs motor neurone to muscle fibre
Neurones motor, sensory or relay vs only motor neurones
Excitatory or inhibitory vs only excitatory
Similarities between cholergic and neuromuscular synapses
Neurotransmitter transported by diffusion.
Receptors cause a reflux of Na+ when neurotransmitter binds.
Use a Na+ / K+ pump to repolarise the axon.
Use enzymes to break down neurotransmitters.