Pharm 5

Question 1

What are the classes of sedative-hypnotic drugs?

Answer 1

• benzodiazepines
• non-benzodiazepines (barbiturates)
• non-benzodiazepines (sedative hypnotics)
• other nonbenzodiazepines

Question 2

Sedative hypnotic drugs:

Benzodiazepines

Answer 2

• Halcion

- Restoril

Question 3

Sedative hypnotic drugs:

Non-benzodiazepines (barbiturates)

Answer 3

• Luminal/phenobarbital
• Nembutal/pentobarbital
• Seconal/secobarbital

Question 4

Sedative hypnotic drugs:

Non-benzodiazepines sedative hypnotics

Answer 4

• Ambien
• Sonata
• Lunesta
• Rozerem

Question 5

Sedative hypnotic drugs:

Other non-benzodiazepines

Answer 5

Tylenol
Advil PM
Benadryl
Nyquil

Etc.

Question 6

Anti-anxiety drugs: classes

Answer 6

• benzodiazepines

- antidepressants

Question 7

Anti-anxiety drugs:

Benzodiazepines

Answer 7

• Valium
• Xanax
• Ativan

Question 8

Anti-anxiety drugs:

Antidepressants

Answer 8

• Cymbalta
• Lexapro
• Paxil
• Zoloft
• Effexor
• XR

Question 9

Which drug classes are used as anti-seizure drugs?

Answer 9

• Barbiturates
• Benzodiazepines
• Hydantoins
• Iminostilbenes
• Succinimides
• Valproates

Question 10

Which benzodiazepines are helpful for acute status epilepticus (not long term)?

Answer 10

• Valium

- Ativan

Question 11

Anti-seizure drugs:

Hydantoins - off-label use

Answer 11

Neuropathic pain

Question 12

Anti-seizure drugs:

Hydantoins - adverse effects

Answer 12

• cerebellar signs

- gingival hyperplasia

Question 13

Anti-seizure drugs: How do iminostilbenes work?

Answer 13

By slowing recovery of Na+ channels from firing too rapidly

Question 14

Anti-seizure drugs:

Iminostilbenes - adverse effects

Answer 14

issues with salt imbalances

• water retention
• antidiuretic hormone release
• cardiac arrhythmias
• CHF

Question 15

Anti-seizure drugs: example of a succinimide drug

Answer 15

Zarontin

Question 16

In addition to seizures, valproate are also used to treat

Answer 16

BP

Question 17

This drug class is used to treat absence seizures

Answer 17

Succinimides (Zarontin)

Question 18

What are 2nd generation anti-seizure drugs?

Answer 18

Used as an add-on to first gen drugs (“specialty drugs”)

Question 19

Which are the two second generation anti-seizure drugs?

Answer 19

• gabapentin

- lyrica

Question 20

Adverse effects of gabapentin (and other anti-anxiety drugs)

Answer 20

• sedation
• fatigue
• dizziness
• ataxia

Question 21

Adverse effects of lyrica

Answer 21

• dizziness
• drowsiness
• peripheral edema

Question 22

How does Lyrica cause peripheral edema?

Answer 22

Inhibition of Ca2+ channels

Question 23

What is the 2nd gen anti-seizure drug, Lyrica, used for?

Answer 23

Chronic pain

• fibromyalgia
• diabetic peripheral neuropathy
• post-herpetic neuralgia