pharmaceutics

Question 1

pharmaceutics

Answer 1

helps relate the formulation of drugs to their delivery and disposition in the body
-formulation of pure drug substance into dosage forms

Question 2

physical chemistry

Answer 2

study of relationship btw the physical/chemical properties of a drug and the fate of drug in vivo (in body) to better design a dosage form

Question 3

things included in physical pharmacy

Answer 3

-solubility
-dissolution
-permeability
-stability
-polymorphism (ability to exist in diff structures)

Question 4

pharmaceutical formulation

Answer 4

process of the chemical substance, including the active drug, combined into medicine or a dosage form

Question 5

when is formulation often finalized?

Answer 5

phase 2 or 3 of clinical trials

Question 6

tablets are usally

Answer 6

mostly fillers and lubricants (80%) and dissolutions (how it dissolves, 10% and about 5-10% drug

Question 7

passive targeting

Answer 7

takes advantage of tissue permeability
-both biological and pharmacological factors affect the drug in a particular location
-usually takes advantage of tissue permeability

Question 8

active targeting

Answer 8

achieved by conjugating the delivery vehicle to a targeting moiety putting the drug accumulation in a specific location
-molecular interaction between carrier and target
-usually achieved by computing delivery

Question 9

pharmaceutical manufacturing

Answer 9

process of industrial scale synthesis of pharmaceutical dosage forms
-broken down into different operations of milling, granulation, coating, and tablet pressing

Question 10

knowing pharmacokinetics can help prescribers with

Answer 10

adjusting dosage forms more accurately and rapidly
-therapeutic drug monitoring

Question 11

pharmaceutics help relate

Answer 11

formation of drugs to their delivery and disposition medication

Question 12

extended release

Answer 12

designed to last longer in body, fewer doses and works for longer period of time
-helps prevent side-effects

Question 13

immediate release

Answer 13

designed to work quickly

Question 14

sustained release (SR)

Answer 14

-type of extended release
-fewer doses, works longer

Question 15

delayed release

Answer 15

-not dissolving in stomach but in small intestine
-has coating to protect it