SMD

Question 1

small molecule drugs

Answer 1

-most common med on the market
-well defined chemical structure
-created through chemical synthesis or derived from natural productd

Question 2

penicilin

Answer 2

-naturally produced by a fungi
-marked beginging of the antibiotic era

Question 3

AZT (retrovir)

Answer 3

-first HIV drug
-made by a failed drug from the 1960s

Question 4

how many SMD were approved in 2020?

Answer 4

75%

Question 5

in 2020, what was the % of sale of SMD

Answer 5

90%

Question 6

what drugs in the piple line are SMD?

Answer 6

70%

Question 7

pros to SMD

Answer 7

-easy chemical structures
-easy to make
-predicitble properties
-various administoring routes
-cheaper/generics

Question 8

brand name v generic

Answer 8

brand name has exclusivity when pt is active
-generics are cheaper and can be covered by insurance

Question 9

cons to SMD

Answer 9

-lack of high specify (off target effects occur)
-risk of drug-drug interactions
-generics
-bioavailability and solubility issues

Question 10

how to increase bioavailibity and solubilty of SMD?

Answer 10

-jet milling (smaller particle size)
-salts/cocrystals
-amorphous solid dispersions

Question 11

ways SMD interact with receptors

Answer 11

-full agonist
-partial agonist
-inverse agonist
-antagonist

Question 12

what is the most common dosage form?

Answer 12

tablets
-long shelf life