Physio Flashcards

(118 cards)

1
Q

Human beings are

A

highly complex species

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2
Q

most important
yet mysterious structure

A

Brain

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3
Q

Our sensations, perceptions,
needs, desires,
feelings, emotions,
thoughts, and memories,
all are guided by
the

A

Very powerful mind

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4
Q

The branch of psychology
concerned with the
relationship between the
physical functioning of an
organism and its behavior.

A

Physiological psychology

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5
Q

It is also the scientific study of
the biological origins of
behavior.

It is the joining of
both psychology and physiology
that permits understanding of
human behavior
; normal and
abnormal.

It tries to explain behavior
in terms of the
physiological change that
occur inside the body.

A

Physiological Psychology

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6
Q

It is not enough to
have good mind; the
main thing is to use
it well.

A

Rene Descartes

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7
Q

PHILOSOPHICAL ROOTS
OF physiological
PSYCHOLOGY

A

Philosophy
Animism
Monoism
Dualism

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8
Q

originally concerned
itself with the basis of human knowledge and thought.

Philosophers soon realized
that in order to understand the basis of knowledge, they must understand the nature of reality,

(‘love of wisdom”)

A

Philosophy

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9
Q

the
predecessor of physical and biological
science.

A

natural philosophy

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10
Q

an ancient belief that natural
phenomena were caused by animating
spirits.

All moving object – “animals, the
wind and tides, the sun, moon, and stars” were assumed to have spirits that caused
them to move.

A

Animism

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11
Q

suggests that the nature of reality is
dual,
that is, the mind and the body
are viewed as being two separate
entities.

It is believed that the body is made
up of the physical material
, while
the mind is not.

A

Dualism

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12
Q

a French philosopher and mathematician, believed that the soul could control the body.

Formulated the first physiological model of behavior.

A

Rene Descartes

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13
Q

believed that the only one sort of
substance is there in the universe.

Thus, the universe consists of only
matter and energy

. When the body
interacts with the environment, the
mind is created.

Human is a unified whole

the mind is a phenomenon produced by the
workings of the body and its
interaction with the muscles.

What we call “mind” is a
consequence of the functioning of
the body and its interactions with
the environment

A

Monism

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14
Q

Under Monism

A

Determinism And Freewill

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15
Q

is a belief
that the world is an
orderly place
where each
events is determined by
the events that precede it

A

Determinism

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16
Q

is a belief that
the mind is not constrained
by physiology
, they are
able to act on their own
will

A

Freewill

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17
Q

BIOLOGICAL ROOTS OF
PHYSIOLOGICALPSYCHOLOGY

A

Luigi Galvani
Johannes Muller
Jean Pierre Flourens
Paul Broca
Gustav Fritsh and Eduard Hitzig
Charles Darwin
Wilhelm Wundt
Herman Von Helmholtz

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18
Q

He was the first scientist who attempted to measure the speed of conduction.

It is slower than 90 ft/seconds
In his 1850 experiment,

measured the speed of the nerve impulse in a frog’s sciatic nerve, finding it to be approximately 90 feet per second (about 27 meters per second).

He used a special instrument called a myograph to measure the time it took for the electrical signal to travel along the nerve, a technique that was a significant innovation at the time and helped to prove that nerve impulses involved physical, not mysterious, processes.

A

HERMAN VON HELMHOLTZ (1821-1994)

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19
Q

He found that stimulation of a frog’s nervecaused the muscle to which it was attached to contract or twitch if electrical current as made to flow through them.

The muscle would contract even when the
muscle and the nerve attached to it were
removed from the rest of the body; thus,
pressurized ventricular.

A

Luigi Galvani

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20
Q

He is one of the founders of experimental
physiology.

His most important
contribution was his “doctrine of specific
nerve energies
.”

He observed that
although all nerves carry the same basic
message (an electric impulse) we perceive the messages of different nerves in
different ways

A

Johannes Muller

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21
Q

Performed the method called
experimental ablation.

He removed
various parts of animals’ brains and
observed their behavior

. By seeing
what the animal could no longer do,
he infer the function of the missing
portion of the brain.

A

Jean Pierre Flourens

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22
Q

Applied the principle of experimental ablation
to human brain
,

he did not intentionally
remove parts of human brain

. Instead, he
observed people whose brain had been
damage by strokes. In 1861 he performed an
autopsy on the brain
of a man who had had
stroke that caused him to lose the ability of
speak, which led Broca’s observation that the
left side of the cerebral cortex performs
functions necessary for speech.

A

Paul Broca

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23
Q

used electrical stimulation as a
tool for understanding the physiology of
the brain.

They applied weak electrical
shock to the exposed surface of a dog’s
cerebral cortex
and found that stimulation
of different portions of a specific region of
the cortex caused contraction of specific
muscles on the opposite side of the body.

A

GUSTAV FRITSCH& EDUARD HITZIG

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24
Q

His
book “Expression of the Emotions in Man
and Animal”

in 1872 talked about the
continuity of facial expressions across
different cultures.

This book is still
important source of valuable information
for the researchers studying emotion

A

Charles Darwin

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25
There has been a **rapid progress in the use of scientific technologies to study human behavior** over the years. It was **after the World War II** when most of the psychologist started studying the brain and the function of the nervous system. Hence, **physiological psychology grew out of psychology**, the first book by Wundt was titled **Principles of Physiological Psychology.**
Wilhelm Wundt
26
_____ area is responsible for speech and _____ area is responsible for language
Broca’s and Wernicke's
27
difficulties with speech fluency and grammatical structure.
Broca's Aphasia
28
is a region in the brain, specifically in the frontal lobe of the dominant hemisphere (usually the left), crucial for **language production and processing. It's involved in forming sentences, coordinating speech,** and understanding grammar
Broca's Area
29
I am not what happened to me to me, I am what I choose to become. -
Carl Gustav Jung
30
METHODSTO STUDY THE FUNCTIONING OF THE LIVING BRAIN
Computerized Tomography (CT scan) Magnetic Resonance Imaging (MRI) Positron Emission Tomography (PET)
31
combines a **series of X-ray images taken from different angles** around your body and uses computer processing to create **cross-sectional images (slices)** of the bones, blood vessels and soft tissues inside your body. images provide **more-detailed information than plain X-rays can do**
Ct Scan
32
is a type of scan that uses **strong magnetic fields and radio waves** to produce detailed images of the inside of the body. is a **large tube that contains powerful magnets.** **You lie inside the tube** during the scan.
Mri
33
an imaging test that helps **reveal how your tissues and organs are functioning.** **uses a radioactive drug (tracer)** to show this activity. This scan **can sometimes detect disease before it shows up** on other imaging tests.
Pet
34
HISTOLOGICAL TECHNIQUES
1. FIXATION 2. SECTIONING a. Freezing b. Embedding 3. STAINING a. Cell-body stains b. Myelin Stains c. Membrane stains d. histofluorescence Method
35
are used to **investigate the anatomy of the brain in detail** . A simple examination of the brain does not provide complete information about the cell structure and the various connections that exist between neuron. Hence, to study neural tissue properly under microscope, it has to fixed and stained
Various histological procedures
36
Procedures to **retain the tissue** in the form it had at the time of the organism’s death ֍ **Destroying the autolytic enzymes** (autolytic means self-dissolving) which will turn the tissue into a shapeless mush ֍ **Preserving the tissue to prevent decomposition** by bacteria or molds through placing it in a **fixative** ֍ “*"Perfusion**” (pouring through) includes **removal of the blood and replacement of another fluid**
Fixation
37
– the tissue is being **chilled with refrigeration device.** The brain is first **soaked in sucrose solution**, which *minimizes tissue damage* by preventing formation of **large ice crystals** as the brain freezes
Freezing, Sectioning
38
– the **tiss**ue is embedded in materials that are of **sliceable consistency** at room temperature such as **paraffin and nitrocellulose** before cutting
Embedding, Sectioning
39
– **methylene blue** was discovered by **Franz Nissl**, a German neurologist; can **stain cell body of brain tissues**; **cresyl violet** – the most frequently used dye
Cell-body stains (also called NISSL stain
40
**colors myelin sheaths"", which can identify fiber bunches, however, pathway of single fiber cannot be traced
Myelin Stain
41
contains **salts of various heavy metals** such as silver, uranium or osmium that interact with the somatic, dendritic and axonal membrane
Membrane Stains
42
– technique for precisely **locating certain kinds of transmitter substances in the brain** . Brain tissue is exposed to **dry formaldehyde gas** **noradrenergic neurons** would fluoresce a bright yellow when the tissue is examined under ultraviolet light
Histoflourescene Method
43
2 Ways for TRACKING BRAIN PATHWAYS
Amino-acid Autoradiography Horseradish Peroxidase (HRP) Technique
44
is a **photographic method used to detect radioactive materials** , among them radiolabeled proteins that are resolved by **2-DE**, since autoradiography energy is able to **penetrate through the gel and onto the photographic film.** **Seeks to look at the origin of the brain**
Amino-acid Autoradiography
45
is an **enzyme used to amplify signal in photometric assays** by catalyzing the conversion of chromogenic or chemiluminescent substrates for the detection of targets such as proteins, carbohydrates, and nucleic acids
Horseradish Peroxidase (HRP) Technique
46
LABORATORY TECHNIQUES
AN ELECTRON MICROSCOPE - STEREOTAXIC SURGERY
47
a technique for **obtaining high resolution images of biological and non-biological specimens.** It is used in biomedical research to investigate the **detailed structure of tissues, cells, organelles and macromolecular complexes.**
Electron Microscope
48
or **stereotaxy** , a *"three dimensional** surgical technique that **enables lesions deep within tissues** to be located and treated using cold (as in cryosurgery), heat, or chemicals **Permits the insertion of an object into the depths of the brain without serious damage to the overlying tissue"" “**Stereotaxis**” means solid arrangement, which has the ability to locate objects in space
STEREOTAXIC SURGERY
49
permits the investigators to locate brain structure hidden from view Used when operating the brain, can drill a part of the brain where the blood clot is located.
Stereotaxic apparatus
50
TECHNIQUES TO STIMULATE THE BRAIN ELECTRICALLY
MICROELECTRODES MACROELECTRODES
51
are **biopotential electrodes"** with an **ultrafine tapered tip** that can be inserted into individual biological cell These electrodes serve an important role in **recording action potentials from single cells** and are commonly used in neurophysiological studies.
Microelectrodes
52
- are considered more suitable for measuring the **collective sum** of slow potentials from multiple cells near the electrode, the local field potential (LFP)
MACROELECTRODES
53
(nerve cell) is the information – processing and information – transmitting element of the nervous system.
neuron
54
parts of the neurons
soma or cell body dendrites axon terminal buttons synapse
55
* **contains the nucleus** and much of the machinery that ***provides for the life** processes of the cell * process neural messages
soma
56
( means tree) * receives the message from another neuron
dendrites
57
transmitters of neuron
axon terminals
58
they make myelin sheaths
schwann cells
59
the conducting fiber
axon
60
insulating fatty layer that speeds transmissions
myelin sheaths
61
is making an analogy/explanation/context that everyone, even outside your field, understands.
generalization
62
there is dissecting the feelings that you are sad.
reduction
63
parts of a typical cell, animal cells
a. cell membrane b. nucleus c. nucleolus d. chromosomes e. cytoplasm f. mitochondria e. endoplasmic reticulum h. golgi apparatus i. lysosomes j. microfilaments k. microtubules
64
- outer boundary of the cells - has protein molecules on the outer surface - called as plasma membrane
cell membrane
65
where proteins are synthesized by the ribosomes
rough er
66
it synthesized lipids, steroid hormones, and some carbohydrates used to form **glycoproteins**
smooth er
67
where carbohydrates are synthesized, combined with protein s. - **packed to form globules** of glycoproteins
golgi apparatus
68
digestive system of the cell - membrane-enclosed organelles that contains an array of enzymes capable of breaking down all types of proteins, nucleic acid, carbo, lipids
lysosomes
69
**has enzymes** that detoxify harmful substances
peroxisomes
70
power plant of the cells helps in ATP synthesis
mitochondria
71
cell's control center - important role in protein synthesis, metabolism, transport and growth - housing the cell's DNA and regulating growth and developments - contains chromatin
nucleus
72
membranous cell structures
lysosomes perixosomes mitochondria nucleus er golgi aparatus plasma membrane
73
non membranous cell strucutres
ribosomes cilia and flagella nucleolus cytoskeleton
74
also called as **protein factories of cells** - synthesizes proteins
RIBOSOMES
75
**cell extensions** which are **hair like**
CILLIA
76
PROPEL THE SPERM CELLS
FLAGELLA
77
has important role in the formation of ribosomes - transcribing rna n
nucleolus
78
**framework** which **supports the cell** and its organelles forms microvilli, cillia, flagella
cytoskeleton
79
thread like structure found in nucleus of cells that carry dna
chromosomes
80
81
are **thin protein filaments** within cytoplasm - made of **actin** filaments
microfilaments
82
hallow, **tube like** protein structures that are crucial for **maintaining cell shape** and **segregating chromosomes during cell divisions**
microtubules
83
the body's communication network - controls both voluntary and involuntary movements
nervous system
84
2 parts of nervous system
1. central nervous system 2. peripheral nervous system
85
the control center of the body - brain and spinal cord
CNS
86
the network of nerves outside the brain and spinal cords - **cranial nerves** (from brain nerves), **spinal nerves** (from spinal cords)
PNS
87
TWO SUBDIVISIONS OF PNS
A. somatic nervous system b. autonomic nervous system
88
controls voluntary movements skeletal muscles
somatic nervous system
89
controls involuntary movements - organs, glands
autonomic nervous systems
90
2 branches of autonomic nervous system
**sympathetic** - fight of flight **parasympathetic** rest and digest
91
An impulse conduction route to and from the CNS (brain & spinal cord)
reflex arc
92
types of neurons
unipolar bipolar multipolar
93
* the most common type found in the CNS * the somatic membrane gives rise to **one axon** but to the **trunks of many dendritic** also known as **motor neuron or efferent** CNS TO PNS
MULTIPOLAR NEURONS
94
* give rise to **one axon** and **one dendritic tree** at opposite ends of the soma KNOWN AS **INTERNEURON**
BIPOLAR NEURONS
95
* has only one stalk that leaves the some and divides into two branches a short distance away KNOWN AS **SENSORY NEURON OR AFFERENT** PNS TO CNS
UNIPOLAR NEURON
96
**receive sensory signals** from sensory organs and **send them via short axons to the central nervous system**
SENSORY NEURONS
97
**conduct motor commands** from the **cortex to the spinal** cord or from the spinal cord to the muscles
MOTOR NEURONS
98
that interconnect various neurons within the brain or the spinal cord
INTERNEURONS
99
neurons with a **short extension** that quickly divides into two branches, one of which functions as a dendrite, the other as an axon
PSEUDO-UNIPOLAR
100
neurons that have short dendrites emanating **from the cell body and one long axon**
MULTIPOLAR
101
that have two main extensions of similar lengths
BIPOLAR NEURONS
102
transmit nerve impulses to the spinal cord or brain
AFFERENT
103
transmit impulses away from the brain or spinal cord
EFFERENT
104
* Conduct impulses from afferent neurons toward or to motor neurons
INTERNEURONS
105
SUPPORTING CELLs
NEUROGLIA ASTROGLIA MICROGLIA OLIGODENROGLIA EPENDYMAL CELLS SCHWANN CELLS
106
* the most important cell in the CNS * “**the nerve glue**”, glues the CNS together * physically and chemically **buffer the neurons** from the rest of the body * **surrounded neurons and hold them in place** * controls supply of chemicals needed * **insulate neurons so that messages will not scramble** * **act as housekeepers**
GLIA / NEUROGLIA
107
* provide **physical support** to the neuron * clean-up debris in the brain * chemically buffers fluid from surrounding neurons * supply neurons with **nutrients** and **dispose their waste products** through the capillaries **ASTROCYTES OR STAR CELLS**
ASTROGLIA
108
* **smaller type of glia**, serves as **phagocytes** engulfing dead neurons
MICROGLIA
109
provide support to axons and **produce myelin sheaths in the CNS**
Oligodendroglia
110
are epithelial cells that monitor the composition of cerebrospinal fluid (CSF). Specialized ependymal cells also participate in the secretion of CSF.
Ependymal Cells
111
supports axon and **produce myelin sheaths in the PNS**
SCHWANN CELLS
112
when the axon of a typical neuron is **injured by cutting**, and **severed the axonal connections from the cell body of the neuron**. The **detached section of the axon had no means of sustaining itself**, and thus died.
Wallerian degeneration
113
when part of the **axon still attached to the cell body** breaks down
Retrograde degeneration
114
WHEN THE **CELL BODY LOSES NISSL SUBSTANCE** AND EVENTUALLY THE CAPACITY TO SUSTAIN INSELF PNS - may sometimes reverse the effects of degeneration and repair CNS- unable to reverse the degeneration process
CHROMOTOLYSIS
115
when a **neuron form synapses** with the dying neuron die too
transsynaptic degeneration
116
117
the most frequently used dye
cresyl violet –
118
) was discovered by **Franz Nissl** a German neurologist; can stain cell body of brain tissues
– methylene blue