what are the main urinary disorders
urinary frequency
incontinence
urinary retention
BPH
what groups of drugs are involved with treating urinary frequency // incontinence
DOTS - Anticholinergics // Muscarinics
Darifenacin
Oxybutynin
Tolterodine
Solifenacin
Mirabegron - Beta 3 adrenoceptor agonist
what drug that is not part of the usual suspects that has an indication for stress incontinence only in women
duloxetine
how can we reduce the side effects of antimuscarinics
giving Mr formulations can help to reduce the side effects
what are the common side effects of anticholinergic / antimuscarinic medication
cant see
cant pee
cant sit
cant shit
what is the first line for nocturnal enuresis
non drug advise
what is the second line for nocturnal enuresis
oral or sublingual desmopressin taken at night
what is the third line for nocturnal enuresis
imipramine
what are the common side effects of desmopressin
hyponatraemia and nausea
what is a potential severe side effect of desmopressin
seizures and convulsions if hyponatraemia is caused
how can we prevent hyponatraemia from occuring with the use of desmopressin
if a patient is to take the medication advise for them to take it 1 hour before or at bedtime and limit fluids for 1 hour before taking the dose and 8 hours after
is urinary retention an emergency
only if acute
how do we treat acute urinary retention
catheter
how do we treat chronic urinary retention
surgically
alpha blockers
name as many alpha blockers that are used in the treatment of chronic urinary retention or BPH
tamsulosin, alfuzosin, doxazosin, and terazosin
what is the most common cause of urinary retention in men
bph
how do we treat bph
alpha blockers
or
5a reductase inhibitors
name two 5a reductase inhibitors
finasteride
dutasteride
in terms of contraception what is important with 5a reductase inhibitors
they are excreted in the condoms so wearing a condom is always recommended
what handling and sotrage requirements are associated with 5a reductase inhibitors
crushed or broken tablets should not be handled by woman of child bearing age
what cancer can 5a reductase inhibitors cause in both men and woman
breast
what mhra warning is associated with finasteride
if it is being used to treat hair loss then people have warned of depression or suicidal thoughts developing
what are alpha blockers contra-indicated in
faint in urinating
what is a major side effect of alpha blockers
1st dose hypertension