what is warfarins relationship with vitamin k
antagonises it as it is associatate with the wors coumarins and phenidiones
what is the main thing to know about warfarin?
takes up to 72 hours to have full effect
WARfarin - like WAR takes a long time to resolve
what strength is the white tablet
0.5mg
what strength is the brown tablet
1mg
what strength is the blue tablet
3mg
what strength is the pink tablet
5mg
what are the two MHRA warning with warfarin
IF a patient has a painful rash an has any form of renal issue refer to GP as coul be a risk calciphylaxis
IF a patient uses miconazole concominantly there is an increase bleeing risk
what is the antiote for wararin
vit k1
aka
phytomenidione
what shoul a warfarin patient avoi
cranberry juice
pomegranate juice
iet change revolving aroun leafy greens
heavy rinkin
pregnancy
what is the ose for MOST conitions warfarin treats
2.5
what are the exceptions to the rule where the target goes to 3.5
recurrant PE / VT
mechanical prosthetic heart valves
what is the acceptable range either sie of the target
0.5
what happens if a patient is bleeing heavily on warfarin
stop
give iv phytomeniione
what happens if a patient is bleeing minor on warfarin
stop
give iv phytomeniione
what happens if patient not bleeing but just has high inr of 8+
give iv phytomeniione ORALLY
stop
what happens if patient has inr between 5-8
stop 2 oses then regive
what meicine can increase warfarin activity
miconazole
amioarone
bezafibrate
what meicine can ecreses warfarin activirty
st john wart
alcohol
carbemazepine
what meicine can cause blee with warfarin
aspirin
clopiogrel (higher with thsi)