Hämatologie > 10. MDS > Flashcards

10. MDS Flashcards

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1
Q

(MDS)

Definition

A

klonale Proliferation
hämatopoetischer Stammzellen

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2
Q

(MDS)

Pathophysiologie

A

dysplastische Zellen mit Apoptoseneigung

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3
Q

(MDS)

Differenzialdiagnosen

A
  • andere Anämie-Formen
  • andere hämatologische Neoplasien
  • reaktive KM-Veränderungen
  • toxische KM-Schäden
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4
Q

(MDS)

Leitbefund

A

Hepatosplenomegalie

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5
Q

(MDS)

Leitbefunde im Blutbild

A
  • hyperchrome makrozytäre Anämie
  • Panzytopenie
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6
Q

(MDS)

Diagnosesicherung
(Befunde)

A
  • Knochenmarkaspirat
    (Dysplasie)
  • Knochenmarkbiopsie
    (Hyperzellularität)
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7
Q

(MDS)

Diagnostik: Faustregel

A

“Penie peripherer, Zellreichtum zentral”

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8
Q

(MDS)

Therapie

A

supportive-
- Transfusionen

MDS-spezifische
- Chemotherapie /
- allogene Stammzelltransplantation

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