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Question 1

1. Patients with some type of MDS are at increased risk of developing
   A. acute lymphoblastic leukemia
   B. AML
   C. chronic lymphocytic leukemia
   D. chronic myelogenous leukemia

Answer 1

B. AML

Question 2

2. Which of the following agents has not been supported by scientific research as being associated with the development of secondary
   MDSs?
   A. Alkylating agents
   B. Organic solvents
   C. Insecticides
   D. Both B and C

Answer 2

D. Both B and C

Question 3

3. An increased incidence of MDSs is seen in
   A. males younger than 55 years of age
   B. females younger than 55 years of age
   C. males older than 55 years of age
   D. females older than 55 years of age

Answer 3

C. males older than 55 years of age

Question 4

4. The most frequently involved chromosomes in adults with MDSs are
   A. 1, 5, and 7
   B. 3, 5, and 8
   C. 5, 7, and 8
   D. 8, 12, and 13

Answer 4

C. 5, 7, and 8

Question 5

5. The most frequent chromosomal abnormalities in children with MDSs include all of the following except
   A. trisomy 8
   B. monosomy 7
   C. deletion of long arm of chromosome 20
   D. all of the above

Answer 5

D. all of the above

Question 6

6. The incidence of chromosomal abnormality in adults with MDSs is
   A. 5% to 15%
   B. 15% to 25%
   C. 25% to 60%
   D. 40% to 90%

Answer 6

D. 40% to 90%

Question 7

7. The karyotype associated with a high probability of transforming to
   AML is
   A. monosomy 5
   B. monosomy 7
   C. trisomy 11
   D. both A and B

Answer 7

D. both A and B

Question 8

8. Patients with MDSs commonly suffer from ______ initially.
   A. a rash
   B. anemia
   C. visual disturbances
   D. vertigo

Answer 8

B. anemia

Question 9

An appropriate description of refractory anemia (RA) is
A. anemia, no blast
B. anemia, less than 1% blasts
C. cytopenia, less than 5% blasts, no Auer rods

Answer 9

B. anemia, less than 1% blasts

Question 10

An appropriate description of refractory anemia with ring sideroblats (RARS) is
A. anemia, no blasts
B. anemia, less than 1% blasts
C. cytopenia, less than 5% blasts, no Auer rods

Answer 10

A. anemia, no blasts

Question 11

An appropriate description of refractory anemia with excess blasts, type 1 RAEB
A. anemia, no blasts
B. anemia, less than 1% blasts
C. cytopenia, less than 5% blasts, no Auer rods

Answer 11

C. cytopenia, less than 5% blasts, no Auer rods

Question 12

In young patients, the therapy of choice for MDSs involves
A. vitamins
B. allogeneic bone marrow transplantation
C. cytotoxic drugs
D. colony-stimulating growth factors

Answer 12

B. allogeneic bone marrow transplantation