Tissues and organs associated with the hematopoietic system include
A. the bone marrow
B. the fetal liver
C. the lymph nodes and thymus
D. all of the above
D. all of the above
The normal sequence of blood cell development is
A. yolk sac—red bone marrow—liver and spleen
B. yolk sac—thymus—liver and spleen—red bone marrow
C. yolk sac—liver and spleen—red bone marrow
D. liver and spleen—yolk sac—red bone marrow
C. yolk sac—liver and spleen—red bone marrow
- The maturational sequence of the thrombocyte (platelet) is
A. megakaryoblast-promegakaryocyte-megakaryocyte- metamegakaryocyte-thrombocyte
B promegakaryocyte-megakaryocyte-metamegakaryocyte -thrombocyte
C. megakaryoblast-promegakaryocyte-megakaryocyte- thrombocyte
D. megakaryoblast-promegakaryocyte-metamegakaryocyte- thrombocyte
C.
megakaryoblast
promegakaryocyte
megakaryocyte
thrombocyte
- The maturational sequence(s) of the erythrocyte is (are)
A. rubriblast-prorubricyte-rubricyte-metarubricyte- reticulocyte-mature erythrocyte
B. prorubricyte-rubricyte-metarubricyte-reticulocyte-mature erythrocyte
C. pronormoblast-basophilic normoblast-polychromatophilic normoblast orthochromic normoblast—reticulocyte—mature erythrocyte
D. both A and C
D. both A and C
- The cell maturation sequence of the segmented neutrophil is
A. promyelocyte-myeloblast-myelocyte-metamyelocyte- band or stab-segmented neutrophil (PMN)
B. myeloblast-promyelocyte-myelocyte-metamyelocyte- band or stab-segmented neutrophil (PMN)
C. monoblast-promyelocyte-myelocyte-metamyelocyte- band or stab-segmented neutrophil (PMN)
D. promyelocyte-myelocyte-metamyelocyte-band or stab- segmented neutrophil (PMN)
B. myeloblast-promyelocyte-myelocyte-metamyelocyte- band or stab-segmented neutrophil (PMN)
6 The hematopoietically active area of bone marrow is (are)
A. yellow marrow
B. red marrow
C. storage compartments
D. calcified structures
B. red marrow
- Bone marrow represents approximately____________ of total body weight and averages 1500 gms. in adults
A. 1.0% to 3.0%
B. 3.5% to 6%
C. 8% to 10%
D. more than 25%
B. 3.5% to 6%
- By age 18, red marrow can be found in the
A. skull bones
B. vertebrae and ribs
C. sternum and pelvis
D. all of the above
D. all of the above
- When the body reverts back to extramedullary hematopoiesis,
abnormal conditions in the bone marrow such as __________ can be present
A. hemolytic or aplastic anemias
B. infiltration by malignant cells
C. overproliferation of a cell line
D. any of the above
D. any of the above
- Stem cells are functionally defined at the single cell level as
A. having the capacity for self-renewal
B. having the capacity of multipotential differentiation
C. being essential in tissues with low cellular turnover
D. A and B
A and B
- The abbreviation MAPCS stands for
A. multiple adult progenitor cells
B. multipotent adult progenitor cells
C. many abnormal progenitor cells
D. multiply active potential cells
B. multipotent adult progenitor cells
- Erythropoiesis occurs in specialized niches (erythropoietic niches) where erythroid precursors can
A. proliferate
B. differentiate
C. enucleate
D. all of the above
D. all of the above
- Erythroid cells account for ____________of nucleated cells in normal bone marrow.
A. 1% to 2%
B. 5% to 38%
C. 40% to 50%
D. >50%
B. 5% to 38%
- During granulopoiesis, mature cells spend an average of __________ in the proliferating pool.
A. <24 hours
B. 1 to 2 days
C. 3 to 6 days
D. >1 week
C. 3 to 6 days
- Once in the blood circulation, granulocytes have an average life span of
A. 1 to 2 hours
B. 2 to 4 hours
C. 6 to 10 hours
D. >24 hours
C. 6 to 10 hours
- Myeloid cells account for_______of the nucleated cells in normal bone marrow.
A. 5% to 10%
B. 15% to 25%
C. 23% to 85%
D. >95%
C. 23% to 85%
- Macrophages in the bone marrow of patients with Gaucher’s disease have __________ in the cytoplasm.
A. iron-rich hemosiderin
B. iron-rich ferritin
C. uncatabolized glucocerebrosides
D. erythrocytes filled with hemoglobin
C. uncatabolized glucocerebrosides
- The term interleukin is used to describe
A. a group of protein molecules
B. cytokines
C. molecules that influence blood cell proliferation, maturation, migration, and adhesion
D. all of the above
D. all of the above
- The major role of hematopoietic growth factors appears to be regulating
A. the proliferation of HPCS
B. the differentiation of HPCS
C. the survival and function of mature blood cells
D. All of the above
D. All of the above
- As a blood cell matures, the overall cell diameter in most cases
A. increases
B. decreases
C. remains the same
B. decreases
As a blood cell matures, the ratio of nucleus to cytoplasm (N:C) in most cases
A. increases
B. decreases
C. remains the same
B. decreases
- The chromatin pattern, in most cells, as the cell matures
A. becomes more clumped
B. becomes less clumped
C. remains the same
A. becomes more clumped
- The presence of nucleoli is associated with
A. immature cells
B. all young cells, except myeloblasts
C. only erythroblasts
D. disintegrating cells
A. immature cells
- In the blast stage of development of leukocytes, the cytoplasm of the cell is
A. dark blue and lacks vacuoles
B. light blue and lacks granules
C. light blue and has specific granules
D. gray with many dark-blue granules
B. light blue and lacks granules
