Pharmacology > ACE I > Flashcards

ACE I Flashcards

(6 cards)

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1
Q

Examples

A
  • Ramipril, enalapril, captopril
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2
Q

Indications

A
  • HTN, CHF, Diabetic nephropathy
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3
Q

Mechanism

A
  • Competitive inhibition of ACE -> Decreased conversion to angiotensin II -> Decreased aldosterone & Vasoconstriction
  • Stops conversion of bradykinin to inactive metabolites
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4
Q

CI

A
  • Renal impairment
  • Hypersensitivity
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5
Q

SE

A

Common: Persistent dry cough, (first dose) hypotension

Important: Renal failure, Hypersensitivity (angio-oedema), hepatitis

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6
Q

Monitoring

A
  • Stop if abnormal LFT, U&E
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