B-Blockers

Question 1

Examples

Answer 1

• Cardioselective (b1) - Bisoprolol, atenolol
• Non-cardioselective (b1/2) - propanalol

Question 2

Mechanism

Answer 2

• Competitive inhibitor of b1 adrenoreceptors Inhibit activation of GPCR -> Reduced CAMP Less intracellular calcium -> Decreased ionotropy

Question 3

Indications

Answer 3

• Angina, MI, Hyperthyroidism, CHF

Question 4

SE

Answer 4

Common: Dizziness/hypotension

Important: bronchoconstriction, bradycardia, hypoglycaemia, reynaud’s

Question 5

CI

Answer 5

• HF, PVD, Poorly controlled DM (can mask effects of hypoglycaemia)
• Avoid in asthma, heart block, hypotension

Question 6

Interaction

Answer 6

• Alcohol (hypotensive effect)
• Antiarrhythmics (bradycardia)
• Anti-hypertensives