Pharmacology > Nitrates > Flashcards

Nitrates Flashcards

(5 cards)

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1
Q

Examples

A
  • Glyceryl trinitrate (GTN), Isosorbide Mononitrate (ISMN), Isosorbide Dinitrate
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2
Q

Mechanism

A
  • Metabolised to form NO -> GMP production -> Inhibits entry of calcium ions -> Vascular smooth muscle relaxation (vasodilation)
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3
Q

Indications

A
  • Acute relief of angina
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4
Q

SE

A

Common: Headaches, postural hypotension

Important: Tolerance, tachycardia, flushing

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5
Q

CI

A
  • Hypothyroidism, MI, CHF, Hypotension
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