Digoxin

Question 1

Class

Answer 1

Cardiac glycosides

Question 2

Mechanism

Answer 2

1. Inhibits sodium potassium ATPase
2. Prolongs phase 4 of cardiac AP
3. Increase preload -> + Inotropic, - chronotropic

Question 3

Indications

Answer 3

• Rate control
• Heart failure

Question 5

SE

Answer 5

Digoxin toxicity; narrow therapeutic window

Confusion

GI upset

Evidence of cardiotoxicity – palpitations, arrhythmias, conduction disturbances

Blurred or yellow vision

Question 6

CI

Answer 6

• Sick sinus syndrome
• Bradycardia (Heart block)
• WPW, Vtach, Vfib
• Hypokalaemia, hypercalcaemia
• Previous MI