Dendrites and cell body ion channels
Chem-gated Na + and cl - (and others - mechanically gated for certain neurons)
Axon hillock ion channels
Voltage gated Na + and K + channels
Axon ion channels
Voltage gated Na + and K + channels
Axon terminals ion channels
Voltage gated Ca 2 + channels
Local potentials
Change in voltage in a small location on the dendrites or cell body membrane of a post synaptic cell
EPSP
Excitatory neurotransmitter opens Na + channels, causing depolarization
IPSP
Releases inhibitory neurotransmitter that opens K + or cL _ channels to cause hyperpolarisation
Spatial summation
Multiple neurons input
Temporal summation
Input from repeated firing of one neuron
Threshold potential
–60mv
Action potential steps
1 VG Na + channels open,2 massive influx causes rapid depolarization 3 at ~30mv, vg Na + inactivates, vg k+ opens and cell repolarizes ,4 VG k+ close slowly causing hyperpolarisation, 5 all VG k+ channels close and membrane goes to -70mv
Absolute refractory period
2nd ap cannot be generated because VG Na + channels are open or inactive
Relative refractory period
2nd AP can only be generated if stimulus is larger than normal because some VG Na + channels are shifting from inactive to closed