BUSINES CLASS 2 Flashcards

(631 cards)

1
Q

Most likely diagnosis for 24F with unilateral headache, photophobia, and N/V?

A

Migraine

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2
Q

Abortive medications for migraines?

A

Mild: NSAID / Acetaminophen
Mod–Severe: Triptans (Sumatriptan, Zolmitriptan), Ergots (DHE)
Antiemetics: Metoclopramide, Prochlorperazine

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3
Q

Prophylaxis options for migraines (if >3/month or ↓QoL)?

A

Beta-blocker (Propranolol) (avoid if asthma)
TCA (Amitriptyline)
Anticonvulsants (Valproate, Topiramate)
CCB (Verapamil)
Riboflavin, Mg

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4
Q

Manifestations of Cluster Headache?

A

Severe unilateral peri-orbital pain, lasts 15 min–3h
Autonomic: Lacrimation, rhinorrhea, ptosis, miosis (Horner’s)
Daily clusters x weeks

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5
Q

Investigations for Cluster Headache?

A

CT/MRI (if first presentation to r/o secondary cause)

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6
Q

Treatment options for Cluster Headache?

A

Acute: 100% O₂ 6–12 L/min, Triptans (SC/IN), intranasal lidocaine, Octreotide
Prophylaxis: CCB (Verapamil), Lithium, Steroids, Topiramate

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7
Q

Why prophylaxis for 35F with migraines 2–3/wk?

A

> 3/month, QoL impaired

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8
Q

Prophylaxis options for migraines (4 classes)?

A

TCA (Amitriptyline)
Anticonvulsant (Valproate, Topiramate)
CCB (Verapamil)
BB (Propranolol)
Supplements: Vit B2 (Riboflavin), Mg

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9
Q

Classes of medications for migraine treatment?

A

NSAID/Acetaminophen
Triptans
Ergots (DHE)
Antiemetics (Metoclopramide, Prochlorperazine)

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10
Q

If vomiting and can’t take PO, what to use?

A

IV/IM Metoclopramide
Sumatriptan SC or IN
DHE nasal spray

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11
Q

Contraindications to triptans/ergots?

A

CAD, Stroke, Uncontrolled HTN
MAOI in last 2 weeks
Pregnancy

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12
Q

Next step for patient with migraines 2–3/wk, failed Tylenol/NSAID?

A

Triptan, Ergot, or Antiemetic

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13
Q

Contraindications for NSAID and Triptan/Ergot?

A

NSAID → PUD, renal disease
Triptan/Ergot → CV/CVA/Pregnancy

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14
Q

Prophylaxis classes for migraines?

A

TCA, BB, CCB, Anticonvulsant, Riboflavin

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15
Q

Why prophylaxis for severe migraine, 4d/month, asthmatic?

A

> 3/month, ↓QoL

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16
Q

Prophylaxis options for asthmatic patient (avoid BB)?

A

TCA (Amitriptyline)
Anticonvulsant (Valproate, Topiramate)
CCB (Verapamil)
Riboflavin

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17
Q

Likely diagnosis for female with IBS + migraines, multiple complaints?

A

Somatization disorder

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18
Q

Non-pharmacological management for somatization disorder?

A

Stick with one physician
Limit investigations
Psychotherapy / Biofeedback
Regular follow-up

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19
Q

New diplopia with normal neuro exam — what to do?

A

Reassure

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20
Q

Risk factors for Stomach Cancer in Japanese patient?

A

FAP, H. pylori, Barrett’s, Gastric surgery, Pernicious anemia
Smoking, Obesity, Pickled/salted/nitrosamines

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21
Q

Symptoms/Exam findings for Stomach Cancer?

A

Wt loss, N/V, Epigastric mass, LAD, Hepatomegaly

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22
Q

Diagnosis for Stomach Cancer?

A

Upper endoscopy

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23
Q

Treatment options for Stomach Cancer?

A

Surgery, Chemo, Radiation
Prevention: Stop smoking/EtOH, treat H. pylori

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24
Q

History red flags for Celiac Disease (35F, diarrhea, anemia)?

A

Wt loss, Anemia, Nocturnal diarrhea, Bloody stool, FHx colon Ca/IBD, Rash

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25
Tests for Celiac Disease?
IgA-tTG + IgA level Small bowel biopsy = Gold standard
26
Advice for managing Celiac Disease?
Gluten-free (no wheat/barley/rye; oats OK if pure) Treat deficiencies (Fe, B12, Folate, Vit D) Dietitian referral DEXA (OP risk) Screen 1st-degree relatives
27
Complications of Celiac Disease?
Osteoporosis, Infertility, NHL, Autoimmune disease
28
Classes of medications for IBD?
5-ASA (Mesalamine, Sulfasalazine) Steroids (Prednisone, Budesonide) Immunosuppressants (Azathioprine, 6-MP, MTX) Antibiotics (Metronidazole, Cipro) Biologics (Infliximab, Adalimumab, Vedolizumab)
29
If chloroquine-resistant area → what drug?
Mefloquine (unless CI).
30
Contraindications to Mefloquine?
Seizures, Psych hx (depression, psychosis, schizophrenia), Conduction abnormalities.
31
Side effects of Mefloquine?
N/V, diarrhea, pruritus, Dizziness, insomnia, vivid dreams, psychosis.
32
Non-pharm prevention for malaria?
Avoid dusk–dawn outdoors, Long sleeves + tuck in, Mosquito nets (insecticide-treated), DEET repellents, Avoid stagnant water.
33
If pregnant & declines malaria meds?
Emphasize strict non-pharm prevention above.
34
Antidote for acetaminophen overdose?
N-acetylcysteine (NAC) – best within 4h.
35
Key labs to monitor in acetaminophen overdose?
INR, Bilirubin, AST, ALT, Creatinine, Glucose.
36
Side effects of NAC?
Anaphylactoid reaction, Flushing, tachycardia, edema, Rare: autoimmune.
37
Absolute contraindications to nitrates?
Hypotension, PDE-5 inhibitor use <48h (tadalafil, sildenafil), Severe anemia, ↑ ICP.
38
Relative contraindications to nitrates?
RV infarct, Brady/tachycardia, Alcohol intoxication.
39
Next investigations for angina?
ECG, Troponins, CK-MB, Lipids, A1C, Cr, Echo, CXR, Stress test (if stable).
40
TM findings in otitis media?
Bulging, immobile TM, Loss of landmarks, erythema, ± Purulent discharge.
41
Advice to parents for otitis media?
Most viral → observe, f/u 48h, Give analgesia, Hand hygiene, Avoid 2° smoke, Vaccinations UTD.
42
When to give antibiotics for otitis media?
No improvement at 48h, <6 months old, Severe symptoms.
43
1st line antibiotic for otitis media?
Amoxicillin 90 mg/kg/day ÷2 x 5 days.
44
Key things to assess in a 1 month well baby visit?
Growth: length, weight, head circumference, Feeding: volume & frequency, wet diapers, Vit D.
45
Eye exam findings in a 1 month well baby visit?
Red reflex bilateral.
46
Hip exam findings in a 1 month well baby visit?
Assess for hip stability (Barlow/Ortolani).
47
SIDS prevention strategies?
No co-sleeping, Avoid smoke exposure, No pillows/stuffed toys.
48
Advice for dad who hunts wild animals?
Store ammo separate from gun, Wash/change clothes before handling baby.
49
Differentials for offensive vaginal discharge?
Bacterial vaginosis (most common), Candida, Trichomonas, PID, Foreign body, Malignancy.
50
If BV suspected → 1st line Rx?
Metronidazole.
51
Confirmatory test for BV?
Vaginal swab microscopy → Clue cells.
52
Advice while on metronidazole?
No alcohol, Avoid douching, No need to treat partner.
53
Differentials for cough, dyspnea, fever in a vaccinated 72M?
Pneumonia, COPD exacerbation, CHF exacerbation, Pulmonary embolism.
54
Preventive advice for cough, dyspnea, fever?
Hand hygiene, Avoid 2° smoke (and quit smoking if applicable).
55
4 steps in management of pneumonia?
CXR, CBC/WBC, CRP, Antibiotic Rx.
56
Immediate Rx for sexual assault?
PEP for HIV, GC, Chlamydia, Emergency contraception, Counseling / Support, Vaccination (Hep B).
57
Advice after sexual assault?
Option to report to police/legal, If no period → return for pregnancy test, HPV vaccination.
58
Best emergency contraception after unprotected sex?
Copper IUD up to 7 days.
59
If levonorgestrel used, side effects?
N/V, abdo pain, Fatigue, dizziness, HA, Breast tenderness.
60
What test later after unprotected sex?
Pregnancy test if no bleeding in 3 weeks.
61
Counseling after unprotected sex?
Use with Gravol to ↓ nausea, Offer long-term contraception, STI screening, HPV vaccination.
62
Signs of OM on TM in a 2y old?
Bulging, immobile, Erythema, opaque, Loss of light reflex.
63
If <48h + mild symptoms in a 2y old, what to do?
Observe + antipyretics, follow up in 48h.
64
If >48h / severe symptoms in a 2y old, what Rx?
Amoxicillin 90 mg/kg/day ÷2 × 5 days.
65
21. 17M found unresponsive – Likely diagnosis?
DKA
66
21. 3 common triggers for DKA?
Infection (UTI, pneumonia), Insulin non-compliance, MI, pregnancy, intoxication
67
21. Important investigations for DKA?
ABG / VBG: pH, HCO₃, anion gap; Glucose, serum ketones; K+, Na+, Cr, Osm; ECG
68
21. Initial treatment for DKA?
IV fluids (NS); Correct K+ first (no insulin if <3.3); IV insulin 0.1 U/kg/hr; Monitor, treat trigger
69
21. Suicide risk factors in DKA?
Age, gender (male), Recent breakup, Chronic illness, Non-adherence to meds
70
22. 20M, chronic constipation + subconjunctival hemorrhage – RFs for subconjunctival hemorrhage?
HTN, Increased venous pressure (vomit, strain, cough, sneeze), Coagulopathy, Trauma, FB, Infection
71
22. Investigations for subconjunctival hemorrhage?
Visual acuity, IOP measurement, Slit lamp exam
72
22. Classes of meds for constipation?
Stool softeners (docusate), Bulk agents (psyllium), Osmotic (lactulose, PEG), Stimulant (bisacodyl, senna)
73
22. Advice for constipation?
High fibre diet, Optimal fluid intake, Regular exercise, Don’t ignore urge to defecate
74
22. Rx for opioid-induced constipation?
Linaclotide, Lubiprostone, Naloxegol
75
23. BPPV (young pt, dizziness + HA) – Diagnostic manoeuvre?
Dix-Hallpike
76
23. Findings in BPPV?
Horizontal or torsional nystagmus
77
23. Rx manoeuvre for BPPV?
Epley’s manoeuvre
78
24. Teenager, eating disorder + cough + SOB – Investigations?
CXR, D-dimer (if PE suspected)
79
24. Meds to help symptoms in eating disorder?
SSRI (for depression/eating disorder)
80
24. Which team members needed for eating disorder?
Dietician, Psychiatrist, Psychologist, Social worker
81
25. ER patient – SOB, cough, dyspnea – Differential diagnoses?
Pneumonia, Asthma exacerbation, COPD exacerbation, MI, CHF, PE, Pneumothorax
82
25. Findings of pneumothorax?
↓ air entry on affected side, Hyperresonance, ↓ chest wall movement, Tracheal deviation to opposite side, Use of accessory muscles
83
25. 1st line management for pneumothorax?
If <3 cm + minimal symptoms → Observe; If >3 cm or symptomatic → Aspiration; If unstable/tension PTX → Needle decompression → chest tube
84
26. Immigrant, no English, spouse interpreting, suspicion high – What is your next step?
Arrange for medical interpreter
85
26. If cupping marks seen – what to ask?
Ask about intimate partner violence (IPV)
86
26. Next step management for IPV?
Safety planning, Offer reporting to authority, Document findings, Follow-up, Social work referral
87
27. Chest pain – life threatening vs urgent causes – Life-threatening causes?
MI, PE, Aortic dissection, Cardiac tamponade, Tension pneumothorax, Esophageal rupture
88
27. Urgent but not immediately fatal causes?
Pneumonia, Pericarditis, CHF exacerbation, Asthma exacerbation, Stable angina, Esophageal spasm
89
28. 40F – routine preventive health screen – What preventive screening tests?
BP, BMI / Waist circumference, Lipids (TC, LDL, HDL), A1C, Pap smear (if indicated), FIT/FOBT for CRC, Mammogram (per age)
90
28. 4 lifestyle advice?
Regular exercise, Avoid smoking, Moderate alcohol intake, Mediterranean diet, Vaccinations (flu, shingles, pneumococcal, Tdap), Seatbelt, sunscreen, safe driving
91
29. 42M – alopecia (denies hair pulling, FHx baldness) – Differential diagnosis?
Androgenetic alopecia, Alopecia areata, Tinea capitis, Traction alopecia, Trichotillomania, Post-trauma scar
92
29. Management for alopecia?
Topical or intralesional steroid (AA), Minoxidil, Wig/hair piece, Camouflage make-up, Dermatology referral
93
30. 63F, HFpEF, worsening symptoms – NYHA classification?
Class II (symptoms with ordinary activity like walking dog)
94
30. Causes of HF?
HTN, CAD / MI, AFib, COPD, Anemia, Thyroid disease, Alcohol / substance abuse, Sarcoidosis / amyloidosis
95
30. Symptoms of HF?
PND, Orthopnea, Fatigue, Peripheral edema, Palpitations, Confusion in elderly
96
30. Medications with mortality benefit in HF?
MRA (spironolactone), ARNI (sacubitril/valsartan), SGLT2 inhibitor (empagliflozin), β-blocker (metoprolol, bisoprolol, carvedilol), ACEi / ARB (ramipril, candesartan)
97
First-line medication class for child with Status Epilepticus?
Benzodiazepines (Lorazepam IV, Diazepam PR, Midazolam IM/buccal if no IV).
98
Supportive measures for child with Status Epilepticus?
Secure airway, breathing, circulation Oxygen if hypoxemic IV glucose if hypoglycemic Suction secretions Draw blood (lytes, glucose)
99
If 2 benzo trials fail, what is the second line treatment?
Fosphenytoin, phenytoin, levetiracetam, or phenobarbital.
100
History features of Stomach Cancer?
Early satiety Weight loss Anemia Epigastric pain Anorexia
101
Physical exam findings in Stomach Cancer?
Pallor Virchow’s node (L supraclavicular) Sister Mary Joseph nodule (umbilical) Ascites Hepatomegaly
102
Paraneoplastic findings in Stomach Cancer?
Acanthosis nigricans Trousseau’s (migratory thrombophlebitis) Dermatomyositis
103
Management principles for a 15y with Intellectual Disability?
Multidisciplinary (psych, OT, PT, social work, education support) Parental training Vocational training Regular follow-up with FP/specialist Family counseling
104
Monitoring required for Lithium patient (FHx hypothyroid)?
Lithium levels (q1–2w initially → q3mo once stable) TSH (risk of hypothyroidism) Renal function LFTs
105
Follow-up schedule for Lithium patient?
Every 1–2 weeks until stable, then every 3 months.
106
Medication classes for COPD with example?
SABA: Salbutamol LABA: Salmeterol SAMA: Ipratropium LAMA: Tiotropium ICS: Budesonide
107
Monitoring tools for COPD?
Spirometry (FEV1/FVC) COPD Assessment Tool (CAT) 6MWT Weight/nutrition Imaging if worsening
108
First-line med before activity for Exercise-Induced Asthma (child)?
SABA (salbutamol).
109
If Exercise-Induced Asthma is not controlled, what to add?
Add ICS/LABA (e.g., Symbicort).
110
Simple clinic test for diagnosis of Exercise-Induced Asthma?
Exercise challenge test (e.g., stair climbing).
111
Triggers to avoid for Exercise-Induced Asthma?
Cold/dry air Smoke Air pollution Chlorine/pool chemicals
112
Practical advice for Exercise-Induced Asthma?
Use Ventolin puffer 10–20 min before exercise, review inhaler technique, spacer if needed.
113
Symptoms of worsening HFpEF patient?
SOB Fatigue Orthopnea/PND Peripheral edema
114
NYHA class if HFpEF patient is only symptomatic with exertion?
Class II
115
Mortality-reducing meds for HFpEF?
ARNI (sacubitril/valsartan) SGLT2i (empagliflozin) MRA (spironolactone) Beta-blocker (metoprolol, carvedilol)
116
Classic symptoms of Child with Croup?
Barky cough Inspiratory stridor Hoarseness Worse at night
117
Initial management for Child with Croup?
Dexamethasone (PO/IM) Nebulized epinephrine if mod–severe Oxygen if hypoxemic
118
Admission criteria for Child with Croup?
Stridor at rest Severe distress/hypoxemia Poor PO intake/dehydration Repeated racemic epi use Unreliable home situation
119
Diagnostic criteria for Kawasaki Disease (Warm CREAM)?
Fever >5 days + 4/5: Conjunctivitis (bilateral, non-exudative) Rash (polymorphous) Extremity changes (erythema, edema, peeling) Adenopathy (cervical >1.5 cm) Mucosal changes (strawberry tongue, cracked lips)
120
Key investigation for Kawasaki Disease?
Echocardiogram (baseline + 6 weeks).
121
Treatment for Kawasaki Disease?
IVIG 2 g/kg single dose (<10 days) High-dose aspirin → low-dose until ESR/platelets normalize
122
Fatal complication of Kawasaki Disease?
Coronary artery aneurysm.
123
Bupropion contraindications?
Seizure disorder Eating disorder Alcohol or benzo withdrawal MAOI use in last 14 days Recent bupropion use
124
Side effects of Bupropion?
Insomnia Dry mouth Restlessness Hypertension Nausea
125
Side effects of Varenicline (Champix)?
Insomnia Vivid dreams Suicidal ideation Psychosis Nausea, constipation
126
AAN classification & return for Grade 1 concussion?
AMS <15 min → return same day if resolved
127
AAN classification & return for Grade 2 concussion?
AMS >15 min → observe, return after 1 wk sx-free
128
AAN classification & return for Grade 3 concussion with LOC <1 min?
LOC <1 min → imaging, admit; return after 1 wk sx-free
129
AAN classification & return for Grade 3 concussion with LOC >1 min?
LOC >1 min → admit, return after 2 wks sx-free
130
What does BP ↑ + pulse ↓ post-injury indicate?
↑ ICP → Cushing’s triad
131
Serious signs that need CT for concussion?
Basal skull fracture signs (Battle’s, raccoon eyes, CSF leak), open/depressed skull fracture, ≥2 vomiting episodes, age >65, GCS <15 after 2h
132
When can a person drive after a first unprovoked seizure?
After 3 months seizure-free, with workup/referral.
133
Driving restrictions after epilepsy diagnosis?
Must be seizure-free for 12 months (compliant).
134
Driving restrictions after a seizure during medication withdrawal?
No driving ×3 months after med change.
135
Driving restrictions after alcohol withdrawal seizure?
Drive only if seizure-free & alcohol-free for ≥12 months.
136
Driving restrictions for sleep-only seizures?
Can drive if unchanged x5 years.
137
Differential diagnosis for viral pharyngitis?
Viral pharyngitis, Strep throat, EBV/Mono, CMV, HIV
138
Classic mono triad?
Fever, pharyngitis, generalized LAD.
139
Investigations for suspected mono?
Monospot (heterophile Ab); if negative → CBC + EBV serology
140
Management of viral pharyngitis/EBV?
Supportive: rest, fluids, analgesia; avoid contact sports ×4 weeks (risk splenic rupture); corticosteroids if airway obstruction.
141
Complications of EBV infection?
Splenic rupture, tonsil hypertrophy → airway obstruction, hepatitis, neurologic (optic neuritis, transverse myelitis)
142
Red flag history features for celiac disease?
Weight loss, anemia, nocturnal diarrhea, blood in stool, FHx GI cancer/IBD
143
Tests for celiac disease?
Serology: IgA anti-tTG (with total IgA); confirm: small bowel biopsy
144
Skin lesion associated with celiac disease?
Dermatitis herpetiformis
145
Advice & management for celiac disease?
Strict gluten-free diet (avoid wheat, rye, barley; oats allowed if pure); replace deficiencies (iron, folate, B12, Vit D, Ca); dietitian referral; BMD baseline + repeat serology q6–12mo; screen 1st-degree relatives.
146
Complications of celiac disease?
Nutritional deficiencies, osteoporosis, infertility, delayed puberty, intestinal T-cell lymphoma, other autoimmune diseases
147
5 main medication classes for IBD?
5-ASA (mesalamine, sulfasalazine), steroids (prednisone, budesonide), immunosuppressants (azathioprine, 6-MP, methotrexate), antibiotics (metronidazole, ciprofloxacin), biologics (infliximab, adalimumab, vedolizumab)
148
Classes & examples of anti-emetic medications?
M1 antagonist: scopolamine; H1 antihistamines: diphenhydramine, dimenhydrinate; D2 antagonists: metoclopramide, prochlorperazine; 5-HT3 antagonist: ondansetron
149
Non-pharmacological strategies for malaria prevention?
Long sleeves, tucked clothing; insect repellent (DEET); insecticide-treated bed nets; avoid outdoors dusk–dawn; remove stagnant water.
150
Contraindications for mefloquine?
Epilepsy, depression, psychosis/schizophrenia, cardiac conduction defects
151
Side effects of mefloquine?
GI upset, pruritus; headaches, dizziness; vivid dreams, insomnia; psychosis/hallucinations
152
X-ray features of osteoarthritis?
Joint space narrowing, subchondral sclerosis, subchondral cysts, osteophytes
153
X-ray features of rheumatoid arthritis?
Bony erosions, symmetric joint space narrowing, cartilage loss, marginal erosions; MRI/US more sensitive.
154
Treatment options for post-herpetic neuralgia?
TCA (amitriptyline, nortriptyline), anticonvulsants (gabapentin, pregabalin), SNRIs (duloxetine, venlafaxine), topical lidocaine or capsaicin
155
Investigations for epididymitis?
Urethral swab for Gram stain & NAAT; midstream urine culture; NAAT urine for GC/Chlamydia
156
Empiric treatment for epididymitis?
Ceftriaxone 250 mg IM once + doxycycline 100 mg BID ×10–14 days
157
GCS Table - Eye opening (4)?
4: Spontaneous 3: To speech 2: To pain 1: None
158
GCS Table - Verbal response (5)?
5: Oriented 4: Confused 3: Inappropriate words 2: Incomprehensible sounds 1: None
159
GCS Table - Motor response (6)?
6: Obeys commands 5: Localizes pain 4: Withdraws from pain 3: Abnormal flexion 2: Extension 1: None
160
GCS Table - Maximum and Minimum scores?
Max = 15, Min = 3
161
4 Principles of Family Medicine (Canada)?
FP is a skilled clinician FP is community-based FP is a resource to a defined population Patient–physician relationship is central
162
Pericarditis - Causes?
Viral, bacterial, fungal Trauma Malignancy Autoimmune (SLE, RA)
163
Pericarditis - Symptoms?
Sharp pleuritic chest pain, ↑ leaning forward, ↓ lying down Fever, fatigue, SOB
164
Pericarditis - Exam findings?
Pericardial friction rub Sinus tachycardia
165
Pericarditis - ECG findings?
Diffuse ST elevation PR depression
166
Pericarditis - Complications?
Effusion, tamponade, constrictive pericarditis
167
Pericarditis - Tamponade signs (Beck’s triad)?
Muffled heart sounds Hypotension ↑ JVP
168
Pericarditis - Management?
NSAIDs Steroids if refractory/autoimmune Bacterial: vanco + ceftriaxone Tamponade: pericardiocentesis, surgical call
169
Plantar Fasciitis - Risk factors?
Athletes Older age Obesity Leg length discrepancy
170
Plantar Fasciitis - Symptoms?
Heel pain, worst in AM/1st steps Pain ↑ with running, prolonged standing
171
Plantar Fasciitis - Exam findings?
Pain at medial calcaneus Pain on passive dorsiflexion
172
Plantar Fasciitis - Differential Diagnosis?
Stress fracture Achilles tendinitis Gout
173
Plantar Fasciitis - Imaging?
X-ray usually normal US: fascia >4 mm
174
Plantar Fasciitis - Management?
Acute: NSAIDs, ice, orthotics, stretching Night splints Local corticosteroid injection Ortho referral if refractory
175
Vitamin B12 Deficiency - Pregnancy complications?
Neural tube defects FTT Developmental delay
176
Vitamin B12 Deficiency - General symptoms (5 Ps)?
Pancytopenia Peripheral neuropathy Papillary atrophy (glossitis) Posterior column neuropathy (↓ vibration, proprioception) Pyramidal signs (incontinence, paraplegia)
177
Vitamin B12 Deficiency - Treatment regimens?
PO: 2000 mcg/day ×2 wk → 1000 mcg/day maintenance IM (pernicious anemia): 1000 mcg daily ×1–2 wk → monthly
178
HIV Patient with C6 # - Differential Diagnosis for neck pain + C6 fracture?
OA/degenerative Osteomyelitis (incl. TB/Pott’s) Spinal epidural abscess Malignancy/mets/myeloma Compression fracture (HIV/steroids/osteoporosis)
179
HIV Patient with C6 # - First step in suspected spinal fracture?
Spinal immobilization + urgent neuro & ortho consult (don’t move until cleared).
180
Before Intubation - Steps?
Explain/consent (if able) Pre-oxygenate (bag-mask O₂) Prepare equipment: correct tube size, suction, meds Confirm placement: auscultate, EtCO₂, chest rise Monitor SpO₂, ECG, BP
181
Kawasaki Disease - Diagnostic criteria (Warm CREAM)?
Fever >5 d + ≥4/5: Conjunctivitis (non-exudative, bilateral) Rash (polymorphous) Extremity changes (erythema, edema, peeling) Adenopathy (cervical >1.5 cm, unilateral) Mucosal changes (strawberry tongue, cracked lips)
182
Kawasaki Disease - Key investigation?
Echocardiogram (initial + 6 wk).
183
Kawasaki Disease - Treatment?
IVIG 2 g/kg once (within 10 d) ASA: high dose → low dose until ESR/plt normalize
184
Kawasaki Disease - Complications?
Coronary artery aneurysm (fatal) Myocarditis/pericarditis (most common)
185
Smoking Cessation Medications - Contraindications to bupropion (Zyban)?
Seizures Eating disorders MAOI within 14 d Recent bupropion use Allergy
186
Smoking Cessation Medications - Side effects of bupropion?
Insomnia ↑ BP Dry mouth Restlessness Nausea
187
Smoking Cessation Medications - Side effects of varenicline (Champix)?
Insomnia Vivid dreams Suicidal ideation Psychosis, depression Nausea, constipation
188
Concussion – Return to Play & Cushing’s - AAN grading system?
See Q41
189
Concussion – Return to Play & Cushing’s - Cushing’s triad?
If BP ↑ + HR ↓ → ↑ ICP
190
Single unprovoked seizure?
No driving × 3 months (need EEG/CT + neuro referral).
191
After epilepsy diagnosis?
Must be seizure-free ≥12 months + compliant.
192
Seizures in sleep only?
Can drive if stable ≥5 years with no change.
193
Medication withdrawal?
No driving × 3 months after med change.
194
Seizure recurrence after withdrawal?
No driving × 6 months.
195
Long-term withdrawal + seizure-free ≥5y?
Eligible for all vehicles.
196
Alcohol withdrawal seizures?
Drive only if EtOH-free + seizure-free ≥1 year.
197
Febrile/toxic seizures?
No restriction if fully recovered.
198
DDx for sore throat?
Viral pharyngitis, Group A strep, EBV mono, CMV, HIV, Influenza.
199
EBV classic triad?
Fever, Pharyngitis, Generalized LAD.
200
Investigations for EBV?
Heterophile Ab test (Monospot). If −: CBC diff + EBV serology (Anti-EBV IgM).
201
Management of EBV?
Supportive (fluids, analgesics, rest). Avoid amoxicillin (→ rash in EBV). Avoid contact sports × 4 weeks (splenic rupture risk). Steroids if airway obstruction.
202
Complications of EBV?
Splenic rupture, Tonsillar hyperplasia → airway obstruction, Fatigue (8–12 wk recovery).
203
Clinical clues for Celiac Disease?
Fatigue, diarrhea, foul-smelling stools, Weight loss, FTT in kids, Extraintestinal: dermatitis herpetiformis, peripheral neuropathy, anemia, infertility, ↓ bone density.
204
Diagnosis of Celiac Disease?
Best serology: IgA anti-tTG (with total IgA). Confirm: small bowel biopsy (villous atrophy).
205
Management of Celiac Disease?
Strict gluten-free (avoid wheat, barley, rye; oats OK if pure). Replace deficiencies: Fe, folate, B12, Vit D, Ca. Dietitian referral. BMD baseline. Repeat serology after 6 months.
206
Complications of Celiac Disease?
Malnutrition, OP/osteoporosis, Intestinal T-cell lymphoma, Autoimmune diseases, Delayed puberty/fertility issues.
207
IBD Treatment – Classes?
5-ASA (mesalamine, sulfasalazine), Steroids (pred, budesonide), Immunosuppressants (azathioprine, 6-MP, methotrexate), Antibiotics (metronidazole, ciprofloxacin), Biologics (infliximab, adalimumab, vedolizumab).
208
Anti-Emetic Classes?
M1 antagonist: Scopolamine, H1 antihistamine: Dimenhydrinate, diphenhydramine, D2 antagonist: Metoclopramide, prochlorperazine, haloperidol, 5-HT3 antagonist: Ondansetron.
209
Non-pharm advice for Malaria Prevention?
Long sleeves, tucked-in clothing, Insect repellents (DEET, picaridin), Insecticide-treated bed nets, Avoid dusk–dawn outdoors, Remove stagnant water.
210
Chemoprophylaxis contraindication example?
Mefloquine contraindicated if: seizures, psychosis, depression, schizophrenia, conduction defects.
211
Side effects of mefloquine?
Nausea, vomiting, diarrhea, Pruritus, dizziness, vivid dreams, insomnia, Rare: psychosis, hallucinations.
212
OA X-Ray Features?
Joint space narrowing (asymmetric), Subchondral sclerosis, Subchondral cysts, Osteophytes.
213
RA X-Ray Features?
Symmetric joint space narrowing, Bony erosions, Cartilage loss, MRI/US more sensitive early.
214
First-line treatments for Post-Herpetic Neuralgia?
TCA (amitriptyline, nortriptyline), Anticonvulsants (gabapentin, pregabalin), SNRI (duloxetine, venlafaxine).
215
Adjuncts for Post-Herpetic Neuralgia?
Topical lidocaine, Capsaicin cream, Opioids only if refractory.
216
Investigations for Epididymitis?
Urethral swab for GC/Chlam NAAT, Midstream urine culture, Urine NAAT for GC/CT.
217
Treatment for Epididymitis?
Ceftriaxone 250 mg IM once + doxycycline 100 mg BID × 10–14 d. Rest, scrotal support, NSAIDs.
218
GCS Reminder?
Eye 4, Verbal 5, Motor 6. ## Footnote Max 15, min 3.
219
What are the 4 Principles of Family Medicine (Canada)?
1️⃣ Skilled clinician 2️⃣ Community-based discipline 3️⃣ Resource to a defined population 4️⃣ Patient–physician relationship is central
220
What is the etiology of Pericarditis?
Viral (most common), bacterial, TB, fungal, trauma, malignancy, autoimmune (SLE, RA)
221
What are the symptoms of Pericarditis?
Sharp pleuritic chest pain → better leaning forward, worse supine; fatigue; exercise intolerance; fever
222
What are the exam findings in Pericarditis?
Pericardial friction rub; sinus tachycardia
223
What are the ECG findings in Pericarditis?
Diffuse ST elevation; PR depression
224
What are the complications of Pericarditis?
Pericardial effusion; constrictive pericarditis; tamponade (Beck triad: ↑JVP, hypotension, muffled heart sounds)
225
What is the treatment for Pericarditis?
NSAIDs ± colchicine; steroids if autoimmune/refractory; bacterial: IV Vanco + ceftriaxone; tamponade: pericardiocentesis + urgent surgical referral
226
What are the risk factors for Plantar Fasciitis?
Athletes; older age; obesity; leg length discrepancy
227
What are the symptoms of Plantar Fasciitis?
Heel pain (medial calcaneus); worse with 1st steps in AM or after rest; worse with running, prolonged standing
228
What are the exam findings for Plantar Fasciitis?
Pain with passive dorsiflexion; pain standing on tiptoes
229
What are the differential diagnoses for Plantar Fasciitis?
Calcaneal stress fracture; Achilles tendinitis; gout
230
What imaging is used for Plantar Fasciitis?
X-ray usually normal; US: fascia thickness >4 mm
231
What is the management for Plantar Fasciitis?
NSAIDs, ICE; orthotics, stretching, strengthening; night splints; steroid injection if refractory; ortho referral
232
What are the pregnancy complications associated with B12 Deficiency?
Neural tube defects; FTT; developmental delay
233
What are the general symptoms of B12 Deficiency (5 P’s)?
Pancytopenia; peripheral neuropathy; papillary atrophy (glossitis); posterior cord involvement (sensory ataxia); pyramidal tract signs (paraplegia, incontinence)
234
What is the treatment regimen for B12 Deficiency?
Oral: 2000 mcg daily × 2 wk → 1000 mcg daily maintenance; IM: 1000 mcg daily × 1–2 wk → monthly for life (if pernicious anemia)
235
What are the differential diagnoses for neck pain + fracture in an HIV patient?
Osteoarthritis / degenerative; osteomyelitis (incl. TB, Potts); spinal epidural abscess; malignancy (mets, myeloma); compression fracture (osteoporosis, steroids, HIV)
236
What’s the first step for an HIV patient with neck pain + fracture?
Spinal immobilization + urgent ortho/neurosurg consult
237
What are the steps before intubation?
Consent if able; pre-oxygenate (bag–mask O₂); prepare equipment: tube size, suction, meds; confirm placement: auscultation, EtCO₂, chest rise; monitor SpO₂, ECG, BP
238
What is the mnemonic for Kawasaki Disease?
Warm CREAM: Fever > 5 days + ≥4/5: Conjunctivitis (non-exudative, bilateral); rash (polymorphous); extremity changes (erythema, edema, peeling); adenopathy (cervical, >1.5 cm); mucosal changes (strawberry tongue, cracked lips)
239
What investigations are done for Kawasaki Disease?
Echo (baseline + repeat 6 wk)
240
What is the treatment for Kawasaki Disease?
IVIG 2 g/kg once (<10 days); ASA high dose → then low-dose until ESR/platelets normalize
241
What is a fatal complication of Kawasaki Disease?
Coronary aneurysm
242
What is a common complication of Kawasaki Disease?
Myocarditis/pericarditis
243
What are the contraindications to Bupropion for smoking cessation?
Seizure disorder; eating disorder; MAOI use in past 2 weeks; Bupropion allergy/previous use
244
What are the side effects of Bupropion?
Insomnia; ↑BP; dry mouth; restlessness; nausea
245
What are the side effects of Champix (Varenicline)?
Insomnia, vivid dreams; suicidal ideation, psychosis; depression; nausea, constipation
246
What is the classification of concussion according to AAN?
Grade 1: AMS <15 min → may return same day if sx resolved; Grade 2: AMS >15 min → out ≥1 wk, return if asymptomatic; Grade 3: LOC <1 min → out ≥1 wk, imaging, admit if needed; Grade 3: LOC >1 min → out ≥2 wk, admit, imaging
247
What is a red flag after a concussion?
↑BP + bradycardia = ↑ICP (Cushing’s triad)
248
What are the high-risk factors according to the Canadian CT Head Rule?
Basal skull fracture (Battle’s, raccoon eyes, CSF leak); suspected open/depressed skull fracture; vomiting ≥2; age ≥65; GCS <15 at 2h post-injury
249
What are the driving regulations for epilepsy?
3 mo after single seizure, 12 mo seizure-free after dx, 5y stable for sleep-only seizure
250
Ddx for pharyngitis?
Viral (adenovirus, EBV, CMV, HIV, influenza, coxsackie, HSV) Bacterial (GAS, Mycoplasma, Chlamydia, GC, diphtheria)
251
Classic Mono triad?
Fever Pharyngitis Generalized LAD
252
Tests for Mono?
Monospot (heterophile Ab) If negative: CBC + EBV serology (anti-EBV IgM/IgG)
253
Management for Mono?
Supportive: hydration, analgesia, rest Steroids if airway obstruction
254
Complications of Mono?
Splenic rupture → avoid contact sports x4wk Tonsil hypertrophy/airway obstruction Hepatitis
255
Key risks of long-term PPI use?
↑ C. diff risk ↓ Mg, ↓ Ca absorption → osteoporosis, fractures ↓ Vit B12 absorption ↑ Pneumonia
256
Red flags in GERD requiring further workup?
Weight loss Anemia Dysphagia/odynophagia Melena/hematemesis Persistent sx despite max therapy Age >50 new sx
257
Presentation of hypercalcemia?
Bones, stones, groans, psychiatric overtones N/V, constipation, arrhythmia, weakness, polyuria/polydipsia, confusion
258
Treatment for hypercalcemia?
IV fluids Calcitonin (fast) IV bisphosphonate (zoledronic acid) Steroids (if lymphoma/MM) Dialysis if severe/refractory
259
Palliative options for bone mets pain?
Radiation ADT (GnRH analogues, orchiectomy) Bisphosphonates/denosumab Analgesia
260
Classic triad of cholecystitis?
RUQ pain, fever, leukocytosis
261
Signs of cholecystitis?
Murphy’s sign (inspiratory arrest) Guarding, rebound
262
Labs for cholecystitis?
↑ WBC Mild ↑ ALP, AST/ALT, bilirubin
263
Imaging for cholecystitis?
US (first line) HIDA if uncertain
264
Complications of cholecystitis?
Empyema, gangrene Perforation Gallstone ileus Cholangitis, pancreatitis
265
Management of cholecystitis?
NPO, IV fluids, analgesia IV abx (ceftriaxone + metronidazole) Surgical referral
266
Risk factors for anxiety disorders?
Female sex FHx anxiety/depression Trauma/abuse Stressful life events Substance use Childhood shyness/overprotection
267
Non-pharmacological treatments for anxiety?
CBT, counselling, relaxation, mindfulness Group therapy, stress reduction
268
Pharmacological treatments for anxiety?
SSRI, SNRI (first-line) Benzos (short-term only)
269
Mnemonic for panic attack symptoms?
STUDENTS FEAR 3Cs Sweating, Trembling, Unsteady, Derealization, Excess HR, Nausea, Tingling, SOB, Fear, Chest pain, Chills
270
Medical causes of agitation in an office?
Hypoxia, hypoglycemia, stroke, infection, withdrawal, meds (steroids, stimulants)
271
Approach to an agitated patient?
Recognize early, de-escalate (calm tone, boundaries, stand near exit) Involve family/security if needed Address underlying cause
272
Pharmacological options if danger in agitation?
Lorazepam, diazepam Haloperidol ± benztropine
273
Differential diagnosis for rapid cognitive decline?
NPH (“wet, wobbly, wacky”) Multi-infarct dementia (CVD) Subdural hematoma Brain tumor/metastases CJD Severe depression (“pseudo-dementia”)
274
Differential diagnosis for poor school performance in new immigrant child?
Hearing/vision impairment Endocrine/metabolic: hypothyroid, anemia, DM, malnutrition Psych: ADHD, depression, PTSD Social: language barrier, bullying
275
Next steps for poor school performance in new immigrant child?
Screen vision/hearing CBC, TSH Mental health assessment School support
276
Fatigue – “PS VINDICATE” mnemonic?
Psychogenic → depression, anxiety, OSA, fibromyalgia, CFS Sedentary lifestyle Vascular → stroke, TIA Infectious → TB, mono, HIV, hepatitis Neoplastic → malignancy Nutrition → iron, B12, folate deficiency Drugs → BB, benzos, antihistamines Idiopathic Chronic disease → CHF, COPD, CKD, CLD Autoimmune → SLE, RA, PMR Toxins → EtOH, heavy metals Endocrine → hypothyroid, DM, Addison’s, Cushing’s
277
When is driving unsafe in dementia?
Multiple MVCs last 5 yrs, caregiver/family concern, aggression/impulsivity, MMSE ≤24, self-restricted driving.
278
How to evaluate driving safety in dementia?
Clinical Dementia Rating ≥1, on-road OT driving assessment.
279
Most likely cause of decreased LOC and ↓RR?
Opioid overdose.
280
Immediate drug for opioid overdose?
Naloxone.
281
Other supportive steps for opioid overdose?
Airway, O₂, IV access, monitor ECG, glucose, pupils.
282
Key features of Parkinson’s Disease (TRAP)?
Tremor (resting, pill-rolling, unilateral), rigidity (cogwheel, lead-pipe), akinesia/bradykinesia (slow, ↓ initiation), postural instability (late).
283
Other signs of Parkinson’s Disease?
Masked facies, hypophonia, micrographia, sleep disturbance, seborrhea.
284
Risk factors for Atrial Fibrillation?
HTN, CAD, MI, HF, valvular disease, thyrotoxicosis, PE, pneumonia, hypoxia, hypoK/Mg, EtOH ('holiday heart'), ASD, sick sinus.
285
Minimum 2 investigations for Atrial Fibrillation?
12-lead ECG, echocardiogram, CBC, INR/PTT, renal/liver panel, TSH, fasting glucose, lipids.
286
Low-risk dental procedure management with DOACs?
Option 1: Continue DOAC, delay dose 4–6h after procedure, use tranexamic mouthwash. Option 2: Hold morning dose, resume next day.
287
Differential diagnosis for chronic abdominal pain on opioids?
Narcotic bowel syndrome, constipation, IBS, IBD, celiac, peptic ulcer, GERD, gallstones, renal stones, ovarian issues, malignancy.
288
Nutrition advice for diabetes?
Carbs 45–60%, protein 15–20%, fat 20–35%, <9% total energy from saturated fat, high fibre 30–50 g/d, low GI, avoid refined carbs, limit EtOH.
289
Exercise advice for diabetes?
150 min/wk aerobic, 2+ sessions resistance/wk.
290
Other lifestyle advice for diabetes?
Weight loss 5–10%, smoking cessation.
291
Child vs Adult grief characteristics?
Children: intermittent grief, limited understanding of death, may need help remembering deceased, longer grief period, depend on caregiver. Adults: continuous grief awareness, mature understanding, fully developed memories, shorter grief period, independent.
292
Physical/emotional symptoms of stress?
Anxiety, depression, headaches, GI upset, HTN, poor sleep, relationship problems.
293
Healthy coping strategies for stress?
Exercise, mindfulness/meditation, breathing exercises, progressive muscle relaxation, counselling/CBT, social support, problem-solving, stressor management.
294
Risk factors for domestic abuse?
Low SES, pregnancy, disability, age 18–24, substance use, history of abuse.
295
Management of domestic abuse?
Recognize: screen for IPV, relate: assess readiness for change, refer: resources, shelters, crisis line, social work, ask about weapons, create safe exit plan, document carefully, support autonomy.
296
Kotter’s 8 Steps for Change?
Create urgency, build guiding coalition, develop vision & strategy, communicate vision, empower broad-based action, generate quick wins, consolidate gains, anchor new approaches in culture.
297
Risk factors for prematurity?
Maternal: multiparity, cervical incompetence, infection, low SES, poor nutrition; Fetal: congenital anomalies, multiple gestation; Past obstetric: short interpregnancy interval, prior PTD; Other: tobacco, alcohol, cocaine, polyhydramnios; Comorbid: DM, thyroid disease, HTN, periodontal disease.
298
Clues for Fetal Alcohol Syndrome (FAS)?
Maternal alcohol use, low birth weight, developmental delay, facial features: flat midface, microcephaly, short palpebral fissures, long smooth philtrum, thin upper lip, CNS dysfunction.
299
Key history to ask for newborn fever?
PROM >18h, maternal fever, chorioamnionitis, maternal GBS status, prematurity.
300
Workup for newborn fever?
CBC, CRP, blood culture, urine C&S, lumbar puncture, CXR if respiratory symptoms, glucose, lytes.
301
Empiric treatment for newborn fever?
Ampicillin + Gentamicin.
302
Fatigue differential diagnosis (PS VINDICATE mnemonic)?
Psychogenic, sedentary lifestyle, vascular, infectious, neoplastic, nutrition, drugs, idiopathic, chronic illness, autoimmune, toxins, endocrine.
303
Anemia clues in a 12 y/o Greek girl?
Ethnicity (thalassemia), low-iron diet, pallor.
304
If MCV 65, Hb 105 in a 12 y/o girl?
Microcytic → check ferritin + Hb electrophoresis.
305
If MCV 97 in a 12 y/o girl?
Macrocytic → check reticulocyte count, B12.
306
Why test her sister for anemia?
Shared genetics (thal trait), diet, financial limitation.
307
Likely causes of fatigue in a 26F with an abusive husband?
Depression, hypothyroidism, anemia, pregnancy.
308
Medication causes of fatigue?
Melatonin, antihistamines.
309
First test for suspected hypothyroidism?
TSH.
310
Most common cause of hypothyroidism?
Hashimoto’s thyroiditis (autoimmune).
311
Diagnosis criteria for Chronic Fatigue Syndrome?
Fatigue >4 mo, not relieved by rest, causes dysfunction + ≥4 of: new HA, sore throat, tender LN, myalgia/arthralgia, unrefreshing sleep, post-exertional malaise, memory/concentration deficit.
312
Differential diagnosis for Chronic Fatigue Syndrome?
Fibromyalgia, anemia, TB, HIV, MG, hypothyroid, DM, OSA, malignancy.
313
Investigations for Chronic Fatigue Syndrome?
CBC, TSH, LFT, lytes, FBG, iron, sleep study.
314
Non-pharmacological treatment for Chronic Fatigue Syndrome?
Reassurance, sleep hygiene, CBT, pacing/exercise, support groups.
315
Pharmacological treatment for Chronic Fatigue Syndrome?
Treat depression/anxiety, NSAIDs for pain.
316
HINTS exam use?
Use only in Acute Vestibular Syndrome (continuous vertigo + nystagmus).
317
Head Impulse test results interpretation?
Abnormal corrective saccade → peripheral; normal → central (stroke).
318
Nystagmus test results interpretation?
Horizontal, unidirectional → peripheral; vertical, bidirectional → central.
319
Test of Skew results interpretation?
Skew deviation → central.
320
Dementia & Driving - Unsafe conditions
Unsafe if: Multiple MVAs, self-restricted driving/family concern, aggression/impulsivity, MMSE ≤24.
321
Dementia & Driving - Evaluation criteria
Clinical Dementia Rating ≥1 → unsafe. On-road OT driving test.
322
ER – Decreased LOC, ↓RR likely cause
Likely cause: opioid overdose. Immediate drug: Naloxone (0.4–2 mg IV/IM q2–3 min, up to 10 mg).
323
Parkinson Disease - TRAP Mnemonic
Tremor (resting, pill-rolling), rigidity (cogwheel, lead-pipe), akinesia/bradykinesia, postural instability. ## Footnote Other features: shuffling gait, mask-like facies, micrographia, hypophonia, sleep disturbance.
324
Atrial Fibrillation - Cardiac risk factors
HTN, cardiomyopathy, valvular disease, MI, pericarditis, ASD.
325
Atrial Fibrillation - Systemic risk factors
Hyperthyroidism, PE, pneumonia, OSA, EtOH ('holiday heart'), hypokalemia/magnesemia.
326
Atrial Fibrillation - Other risk factors
Rheumatic heart disease, sick sinus.
327
Atrial Fibrillation - Investigations
ECG, Echo (size, EF, valves), CBC, INR, renal/liver, TSH, glucose, lipids.
328
DOAC & Simple Tooth Extraction - Bleeding risk
Bleeding risk: low. Options: Hold DOAC on day of procedure, resume next day; Continue DOAC, but delay dose 4–6h post-procedure + use tranexamic acid mouthwash.
329
Chronic Abdominal Pain – On Opioids - Differential Diagnosis
Narcotic bowel syndrome, ectopic pregnancy, ovarian torsion, nephrolithiasis, constipation, bowel obstruction, malignancy, biliary colic, hepatitis.
330
DM – Non-Pharmacological - Nutrition
Carbs 45–60%, protein 15–20%, fat 20–35% (<9% sat fats), low GI carbs, ↑ fibre (30–50 g/day), limit EtOH.
331
DM – Non-Pharmacological - Exercise and Lifestyle
Exercise: 150 min/week aerobic + resistance ≥2x/week. Weight loss: 5–10% if overweight. Lifestyle: smoking cessation, stress mgmt, consistent carb intake.
332
Child vs Adult Grief - Children characteristics
Intermittent grief, limited understanding of death, limited memory pre-puberty, grieve longer, depend on caregiver.
333
Child vs Adult Grief - Adult characteristics
Continuous grief awareness, mature understanding of death, complete memory of deceased, independent in basic needs.
334
Child grief features
Risk of prolonged grief, PTSD, depression, anger, loss of security.
335
Risky Behaviours (Adolescents)
Violence, alcohol, tobacco, drugs, risky sex, eating disorders, crime/law-breaking.
336
Risky Behaviours - Reasons for not changing
Stage of change (not ready), ambivalence, no internalized risk perception.
337
Mammogram - When to Stop
Stop at age 74 (if previous normal screens).
338
Palliative Lung Ca – Confusion DDx
Opioid toxicity, Opioid withdrawal, Hypoxia, Brain metastases, Infection (PNA, UTI), Stroke/TIA, Hypercalcemia (paraneoplastic)
339
Infertility – When to Investigate for <35 yrs
After 12 months trying
340
Infertility – When to Investigate for 35–40 yrs
After 6 months
341
Infertility – When to Investigate for >40 yrs
Immediately
342
Infertility – When to Investigate sooner
Sooner if hx: PID, pelvic surgery, chemo/radiation, recurrent miscarriage, severe endometriosis
343
Infertility – Who to investigate
Both partners
344
Prematurity – Maternal Risk Factors
Multiparity, cervical incompetence, STI/UTI, vaginitis, low SES, poor nutrition
345
Prematurity – Fetal Risk Factors
Congenital anomaly, multiple gestation
346
Prematurity – Other Risk Factors
PROM, polyhydramnios, short interpregnancy interval, prior preterm delivery, age <17 or >35, smoking/EtOH, physical abuse, OSA, DM/HTN, uterine anomalies
347
Fetal Alcohol Syndrome (FAS) Hx clues
Maternal EtOH use, LBW, cognitive/attention deficits
348
Fetal Alcohol Syndrome (FAS) Facial Features
Flat midface (maxillary hypoplasia), Microcephaly, Short palpebral fissures, Long smooth philtrum, Thin upper lip
349
Fetal Alcohol Syndrome (FAS) CNS dysfunction
ADHD, learning disability, intellectual impairment
350
Newborn Sepsis – Key Hx
Ask about: PROM >18h, Maternal GBS status, Maternal fever / chorioamnionitis, Prematurity
351
Fatigue – PS VINDICATE Mnemonic
Psychogenic → depression, anxiety, OSA, fibromyalgia, CFS; Sedentary lifestyle; Vascular → stroke, TIA; Infectious → mono, TB, HIV, hepatitis; Neoplastic → malignancy; Nutrition → IDA, B12, folate deficiency; Drugs → BB, benzos, antihistamines, anticholinergics; Idiopathic; Chronic illness → CHF, COPD, CKD, CLD; Autoimmune → SLE, RA, PMR; Toxins → EtOH, heavy metals; Endocrine → hypothyroid, DM, pregnancy, Addison’s, Cushing’s
352
Chronic Fatigue Syndrome (CFS) Dx criteria
Unexplained persistent fatigue >4 mo + dysfunction + ≥4: Impaired memory/concentration, Sore throat, tender LNs, Myalgia/arthralgia, Non-restorative sleep, New HA, Post-exertional malaise >24h
353
Chronic Fatigue Syndrome (CFS) DDx
Fibromyalgia, anemia, depression, mono, HIV, TB, hypothyroid, DM, malignancy, OSA
354
Chronic Fatigue Syndrome (CFS) Ix
CBC, TSH, LFTs, lytes, glucose, iron, sleep study
355
Chronic Fatigue Syndrome (CFS) Tx
Reassurance, sleep hygiene, CBT, support groups, graded exercise, antidepressants, NSAIDs
356
Dizziness in ER – HINTS Exam Use
Use if: acute vestibular syndrome (continuous vertigo + nystagmus)
357
Dizziness in ER – Head Impulse Test
Abnormal (corrective saccade) → peripheral; Normal → central
358
Dizziness in ER – Nystagmus Test
Unidirectional horizontal → peripheral; Vertical/torsional/bidirectional → central
359
Dizziness in ER – Test of Skew
Vertical misalignment = central cause (stroke)
360
Dementia & Driving – Risk Factors
Multiple MVCs, Family concern, Aggressive behaviour, Self-restricted driving, MMSE ≤24
361
Dementia & Driving – Assessment Tools
Clinical Dementia Rating ≥1, On-road OT driving assessment
362
ER – Decreased LOC & RR Immediate drug
Naloxone (suspected opioid overdose)
363
75M post-stroke, depressed mood, ↓sleep, ↓appetite. Q: Dx? Next step?
Post-stroke depression. Start SSRI (sertraline). Monitor suicidality.
364
27F, fatigue, ↑weight, cold intolerance, dry skin, ↓TSH. Q: Dx?
Hypothyroidism. Start levothyroxine. Check anti-TPO for Hashimoto’s.
365
55M, smoker, hemoptysis, wt loss, CXR R hilar mass. Q: Dx?
Lung cancer. Next → chest CT, biopsy, refer oncology.
366
6M infant, projectile non-bilious vomiting, olive-like mass RUQ. Q: Dx & Ix?
Pyloric stenosis. Do abdominal US.
367
22F, STI risk, mucopurulent DC, friable cervix. Q: Likely pathogen & Rx?
Chlamydia/Gonorrhea. Rx ceftriaxone IM + doxycycline/azithromycin.
368
50M, progressive dysphagia solids → liquids, wt loss. Q: Most concerning dx?
Esophageal carcinoma. Do endoscopy + biopsy.
369
34F, G2P1, 30wks, BP 160/110, proteinuria. Q: Dx & Rx?
Severe pre-eclampsia. Admit, IV labetalol/hydralazine, MgSO₄, plan delivery.
370
16F, amenorrhea, galactorrhea, visual field loss. Q: Dx & Ix?
Prolactinoma. Order MRI pituitary.
371
70F, back pain, ↑Ca, anemia, renal dysfunction. Q: Likely dx?
Multiple myeloma. Ix: SPEP/UPEP, bone marrow biopsy.
372
45M, acute scrotal pain, tender high-riding testis, absent cremasteric reflex. Q: Dx?
Testicular torsion. Emergency urology consult.
373
80F, delirium, on oxycodone, constipation. Q: Cause & prevention?
Opioid-induced delirium. Prevention: bowel regimen, review meds.
374
25M, motorcycle crash, hypotension, distended neck veins, muffled heart sounds. Q: Dx & Rx?
Cardiac tamponade. Do emergent pericardiocentesis.
375
5F, vesicular rash in crops, fever. Q: Dx & advice?
Chickenpox (VZV). Supportive. Isolate until crusted.
376
19M, bone pain, sickle cell anemia, fever, salmonella suspected. Q: Dx & Rx?
Osteomyelitis. Treat with ceftriaxone/fluoroquinolone.
377
50M, sudden painless monocular vision loss, cherry red spot. Q: Dx & immediate step?
CRAO. Ocular massage, urgent ophthalmology.
378
3M infant, fever, bulging fontanelle, irritability. Q: Likely dx & Rx?
Bacterial meningitis. Start IV cefotaxime + vancomycin ± ampicillin.
379
25F, postpartum, SOB, orthopnea, JVP↑, crackles. Q: Dx?
Postpartum cardiomyopathy. Echo → LV dysfunction.
380
36M, HIV+, fever, cough, hypoxia, CXR bilateral infiltrates. Q: Dx & Rx?
PCP pneumonia. Rx TMP-SMX ± steroids if PaO₂ <70.
381
40F, HA, bitemporal hemianopia, galactorrhea. Q: Dx?
Pituitary adenoma. Confirm with MRI.
382
60M, hematuria, painless, smoker. Q: Dx & next step?
Bladder cancer. Order cystoscopy + biopsy.
383
51. 22F, dysuria, frequency, suprapubic pain, afebrile. Q: Dx & Rx?
Acute uncomplicated cystitis. Treat with nitrofurantoin x5d or TMP-SMX x3d.
384
152. 65M, smoker, digital clubbing, chronic cough, sputum. Q: Likely dx & confirmatory test?
COPD. Confirm with spirometry (FEV1/FVC <0.7).
385
153. 40F, fatigue, wt gain, TSH high, T4 low. Q: Dx & Rx?
Hypothyroidism. Start levothyroxine, monitor TSH.
386
154. 28M, painful vesicles on erythematous base, recurrent. Q: Dx?
Genital herpes (HSV-2). Treat with acyclovir.
387
155. 75F, hip fracture after minor fall, kyphosis. Q: Likely dx?
Osteoporosis. Confirm with DEXA.
388
156. 8M, sore throat, sandpaper rash, strawberry tongue. Q: Dx & Rx?
Scarlet fever. Treat with penicillin V or amoxicillin.
389
157. 34F, malar rash, photosensitivity, arthritis, nephritis. Q: Dx & key test?
SLE. ANA (sensitive), anti-dsDNA (specific).
390
158. 68M, tremor at rest, rigidity, bradykinesia, postural instability. Q: Dx & Rx?
Parkinson’s disease. Start levodopa/carbidopa.
391
159. 60M, epigastric pain, wt loss, early satiety. Q: Dx?
Gastric cancer. Confirm with endoscopy + biopsy.
392
160. 22M, RLQ pain, fever, rebound tenderness. Q: Dx & next step?
Acute appendicitis. Order surgical consult.
393
161. 10F, polyuria, polydipsia, wt loss, ketones in urine. Q: Dx & Rx?
Type 1 diabetes with DKA. Admit, IV fluids, insulin, correct electrolytes.
394
162. 55F, hot flashes, irregular menses, FSH↑. Q: Dx?
Menopause/perimenopause. Counsel lifestyle ± HRT if no contraindication.
395
163. 19M, sore throat, fever, splenomegaly, atypical lymphocytes. Q: Dx & advice?
Infectious mononucleosis (EBV). Supportive, avoid sports x4w (risk splenic rupture).
396
164. 50F, tender thyroid, fever, post-viral. Q: Dx?
Subacute (de Quervain’s) thyroiditis. Rx NSAIDs ± steroids.
397
165. 60M, wt loss, jaundice, pruritus, palpable non-tender gallbladder. Q: Dx?
Pancreatic cancer (Courvoisier’s sign).
398
166. 7F, hematuria after sore throat 2wks ago, periorbital edema. Q: Dx & Ix?
Post-strep GN. Do urinalysis, ASO titer.
399
167. 34F, G3P2, 10wks, painless vaginal bleeding, US “snowstorm”. Q: Dx?
Molar pregnancy. Evacuate uterus, monitor β-hCG.
400
168. 45M, chest pain, radiates to jaw, relieved by nitro. Q: Dx?
Stable angina. Confirm with stress test.
401
169. 6M, lethargy, vomiting, hepatomegaly, hypoglycemia. Q: Likely dx?
Reye’s syndrome (post-ASA use in viral illness).
402
170. 20F, fatigue, pallor, Hb 85, MCV 70. Q: Dx & cause?
Microcytic anemia → iron deficiency (menorrhagia most likely).
403
171. 40F, diarrhea, flushing, wheeze. Q: Likely dx & test?
Carcinoid syndrome. Check urinary 5-HIAA.
404
172. 65M, hematemesis, chronic EtOH use, ascites. Q: Dx & Rx?
Esophageal varices. Start octreotide + ceftriaxone, urgent endoscopy.
405
173. 72F, postmenopausal bleeding. Q: Most important Ix?
Endometrial biopsy (rule out endometrial cancer).
406
174. 50M, smoker, chronic cough, hemoptysis, cavitary lesion on CXR. Q: Dx?
TB until proven otherwise. Order sputum AFB.
407
175. 6F, itchy vesicles on hands/feet + oral ulcers. Q: Dx?
Hand-foot-mouth disease (Coxsackie virus). Supportive care.
408
176. 33F, recurrent miscarriages, livedo reticularis, thrombosis hx. Q: Dx?
Antiphospholipid antibody syndrome. Test: lupus anticoagulant, anticardiolipin Ab.
409
177. 60M, sudden painless vision loss, “cherry red spot” retina. Q: Dx & management?
Central retinal artery occlusion. Immediate ocular massage + call ophtho.
410
178. 55M, smoker, painless hematuria. Q: Likely dx?
Bladder cancer. Confirm with cystoscopy + biopsy.
411
179. 7F, fever, sore throat, muffled voice, trismus, uvula deviation. Q: Dx & Rx?
Peritonsillar abscess. ENT consult, IV Abx, drainage.
412
180. 45M, polyuria, polydipsia, Na 150, dilute urine, urine osmolality low. Q: Dx?
Diabetes insipidus. Do water deprivation test.
413
181. 2M, fever, irritability, bulging fontanelle. Q: Dx & next step?
Bacterial meningitis. Start IV ceftriaxone + vancomycin immediately.
414
182. 30F, dysuria, sterile pyuria, pelvic pain. Q: Likely dx?
Chlamydia urethritis. Test NAAT, Rx doxycycline or azithromycin.
415
183. 28M, recurrent kidney stones, hexagonal crystals. Q: Dx?
Cystinuria (inherited). Confirm with cyanide-nitroprusside test.
416
184. 70M, proximal muscle weakness, rash on eyelids/knuckles. Q: Dx?
Dermatomyositis. Check CK, anti-Jo-1 Ab. Screen for malignancy.
417
185. 3M, sudden colicky abdo pain, currant jelly stool, sausage mass. Q: Dx & Ix?
Intussusception. Confirm with US. Air/contrast enema is diagnostic + therapeutic.
418
186. 40M, alcohol hx, tremor, agitation, confusion, hallucinations. Q: Dx & Rx?
Delirium tremens. Treat with IV benzodiazepines, thiamine before glucose.
419
187. 6F, fatigue, splenomegaly, pancytopenia, blasts on smear. Q: Dx?
Acute lymphoblastic leukemia (ALL).
420
188. 72M, fever, new murmur, splinter hemorrhages. Q: Dx & Ix?
Infective endocarditis. Order 3 sets blood cultures + echo.
421
189. 30F, vaginal pruritus, thick white cottage-cheese discharge. Q: Dx & Rx?
Candida vulvovaginitis. Treat with fluconazole or topical azole.
422
190. 66M, cough, weight loss, hilar mass. Q: Dx?
Lung cancer. Confirm with bronchoscopy + biopsy.
423
191. 60M, alcohol hx, palmar erythema, gynecomastia, spider angiomas. Q: Dx?
Chronic liver cirrhosis. Monitor for HCC with AFP + US.
424
192. 30F, HTN, hypokalemia, metabolic alkalosis. Q: Likely dx?
Primary hyperaldosteronism (Conn syndrome). Confirm with aldosterone/renin ratio.
425
193. 18M, groin swelling, pain, cannot reduce, tender, vomiting. Q: Dx?
Strangulated inguinal hernia. Emergency surgical consult.
426
194. 45F, exophthalmos, heat intolerance, tachycardia. Q: Dx & confirmatory test?
Graves’ disease. Confirm with TSH (low), free T4 (high), TSH-receptor Ab.
427
195. 70F, fatigue, macrocytic anemia, ↓vibratory sense. Q: Dx?
Vitamin B12 deficiency (pernicious anemia common cause).
428
196. 50M, sudden severe tearing chest pain radiating to back, asymmetric BP. Q: Dx & test?
Aortic dissection. Confirm with CT angiography.
429
197. 24F, RLQ pain, mucopurulent discharge, CMT tenderness. Q: Dx & Rx?
PID. Start empiric ceftriaxone IM + doxycycline PO.
430
198. 55M, painless jaundice, elevated ALP + bilirubin. Q: Dx?
Cholangiocarcinoma (biliary tract cancer).
431
199. 16M, new-onset psychosis, odd behaviour, cannabis use. Q: Likely dx?
Substance-induced psychosis (rule out primary psych).
432
200. 25F, fever, flank pain, dysuria, CVA tenderness. Q: Dx & Rx?
Acute pyelonephritis. Treat with oral ciprofloxacin or IV ceftriaxone if severe.
433
201. What is the diagnosis for a 30F with fatigue, hypotension, skin hyperpigmentation, hyponatremia, and hyperkalemia?
Addison’s disease (primary adrenal insufficiency). ## Footnote Test: AM cortisol, ACTH stimulation test.
434
202. What is the diagnosis for a 19M with urethral discharge, dysuria, and gram − diplococci on smear?
Gonorrhea. ## Footnote Rx: Ceftriaxone IM + doxycycline PO.
435
203. What is the diagnosis for a 60M with cough, weight loss, and SIADH labs (Na↓, osmolality↓, urine osm↑)?
Small-cell lung cancer (paraneoplastic SIADH).
436
204. What is the diagnosis for a 70M with resting tremor, cogwheel rigidity, and bradykinesia?
Parkinson’s disease. ## Footnote Rx: Levodopa/carbidopa.
437
205. What is the diagnosis for a 40F with episodic palpitations, diaphoresis, and HTN?
Pheochromocytoma. ## Footnote Test: Plasma free metanephrines.
438
206. What is the diagnosis for a 26F with amenorrhea, galactorrhea, and headaches?
Prolactinoma. ## Footnote Test: Serum prolactin + MRI pituitary.
439
207. What is the diagnosis for an 8M with fever, sandpaper rash, strawberry tongue, and pharyngitis?
Scarlet fever (GAS). ## Footnote Rx: Penicillin V.
440
208. What is the management for a 70M with new AF, INR 1.0, and CHADS-VASC = 4?
Start anticoagulation (DOAC/warfarin).
441
209. What is the diagnosis for a 22F with RLQ pain, fever, and rebound tenderness?
Appendicitis. ## Footnote Ix: US (young F), CT (adults). Rx: Appendectomy.
442
210. What is the diagnosis for a 35M with trauma, BP 80/40, JVD, and muffled heart sounds?
Cardiac tamponade. ## Footnote Triad: Beck’s triad. Rx: Pericardiocentesis.
443
211. What is the diagnosis for a 10M with URI then limp, hip pain, and well-appearing?
Transient synovitis. ## Footnote Key: Differentiate from septic arthritis (fever, toxic, high CRP).
444
212. What is the diagnosis for a 68F with postmenopausal bleeding?
Endometrial cancer until proven otherwise. ## Footnote Test: Endometrial biopsy.
445
213. What is the diagnosis for a 55M, smoker, with weight loss and persistent hoarseness?
Laryngeal cancer. ## Footnote Test: Laryngoscopy + biopsy.
446
214. What is the diagnosis for a 40M with HIV+, white plaques in mouth that scrape off?
Oral candidiasis. ## Footnote Rx: Fluconazole.
447
215. What is the diagnosis for a 30F with recurrent oral ulcers, genital ulcers, and uveitis?
Behçet’s syndrome.
448
216. What is the diagnosis for a 2M with projectile non-bilious vomiting and olive mass?
Pyloric stenosis. ## Footnote Test: Abdo US. Lab: Hypochloremic metabolic alkalosis.
449
217. What is the diagnosis for a 4M with meningitis and purpuric rash?
Meningococcal meningitis. ## Footnote Rx: IV ceftriaxone ASAP.
450
218. What is the diagnosis for a 29F with painful genital vesicles and dysuria?
HSV genital infection. ## Footnote Rx: Acyclovir.
451
219. What is the diagnosis for a 35M with cirrhosis, confusion, and asterixis?
Hepatic encephalopathy. ## Footnote Rx: Lactulose.
452
220. What is the diagnosis for a 16F with syncopal episode and prolonged QT on ECG?
Long QT syndrome. ## Footnote Risk: Sudden death. Rx: Beta-blockers, avoid QT drugs.
453
221. What is the diagnosis for an 8F with abdominal mass crossing midline?
Neuroblastoma (adrenal origin). ## Footnote Test: Urinary VMA/HVA.
454
222. What is the diagnosis for a 35M with IV drug use, fever, and murmur?
Infective endocarditis (tricuspid valve). ## Footnote Rx: IV vancomycin ± gentamicin.
455
223. What is the diagnosis for a 60F with proximal weakness, rash, and elevated CK?
Polymyositis. ## Footnote Test: Muscle biopsy.
456
224. What is the diagnosis for a 40M with bone pain, ↑ALP, and normal Ca/PO₄?
Paget’s disease of bone. ## Footnote Rx: Bisphosphonates.
457
225. What is the diagnosis for a 65M with painless jaundice and Courvoisier’s sign?
Pancreatic cancer. ## Footnote Test: CT pancreas.
458
226. What is the diagnosis for a 28F with sudden severe headache, photophobia, and neck stiffness?
SAH. ## Footnote Test: Non-contrast CT; if negative → LP (xanthochromia).
459
227. What is the diagnosis for a 70M with fever, confusion, crackles, and CXR = lobar consolidation?
CAP (pneumonia). ## Footnote Rx: Ceftriaxone + azithromycin.
460
228. What is the diagnosis for a 10F with itchy perianal region, worse at night?
Enterobius vermicularis (pinworm). ## Footnote Test: Tape test. Rx: Albendazole.
461
229. What is the diagnosis for a 32F with erythema nodosum and hilar LAD?
Sarcoidosis. ## Footnote Test: CXR, ACE level.
462
230. What is the diagnosis for a 24M with hemoptysis, hematuria, and anti-GBM Ab?
Goodpasture syndrome.
463
231. What is the diagnosis for a 50M with painless hard scrotal mass?
Testicular cancer (seminoma until proven otherwise). ## Footnote Test: US, AFP/β-hCG. Rx: Radical orchiectomy.
464
232. What is the diagnosis for a 15F with knee pain and small round blue-cell tumor in the diaphysis?
Ewing sarcoma.
465
233. What is the diagnosis for a 14M with atraumatic limp, hip/knee pain, and obesity?
SCFE. ## Footnote Test: Hip X-ray (frog leg). Rx: Surgical pinning.
466
234. What is the diagnosis for a 6M with hepatosplenomegaly, doll-like face, and hypoglycemia?
Von Gierke’s disease (GSD type I).
467
235. What is the diagnosis for a 70F with scalp tenderness, jaw claudication, and vision loss?
Giant cell arteritis. ## Footnote Rx: High-dose prednisone immediately.
468
236. What is the diagnosis for a 40F with diplopia, ptosis, and improvement with rest?
Myasthenia gravis. ## Footnote Test: ACh receptor Ab, EMG. Rx: Pyridostigmine.
469
237. What is the diagnosis for a 22F with 'worst headache', N/V, papilledema, and obesity?
Idiopathic intracranial HTN. ## Footnote Rx: Acetazolamide.
470
238. What is the diagnosis for a 30M with bloody diarrhea, PSC, and ↑pANCA?
Ulcerative colitis.
471
239. What is the diagnosis for a 45M with chronic cough, sputum, and dilated bronchi on CT?
Bronchiectasis. ## Footnote Cause: CF, infection. Rx: Airway clearance, Abx.
472
240. What is the diagnosis for a 3M with recurrent sinopulmonary infections and no thymic shadow?
DiGeorge syndrome (22q11). ## Footnote Features: Hypocalcemia, cardiac defects, cleft palate.
473
241. What is the diagnosis for a 19F with fever, sore throat, posterior LAD, and splenomegaly?
Infectious mononucleosis (EBV). ## Footnote Test: Monospot, avoid amoxicillin.
474
242. What is the diagnosis for a 65M with trauma, confusion, and bitemporal hemianopia?
Pituitary apoplexy. ## Footnote Rx: High-dose steroids + neurosurg consult.
475
243. What is the diagnosis for a 50F with non-healing leg ulcer, palpable purpura, and hep C+?
Cryoglobulinemia.
476
244. What is the diagnosis for a 35F with recurrent mouth ulcers and iron-deficiency anemia?
Celiac disease. ## Footnote Test: IgA-tTG, duodenal biopsy.
477
245. What is the diagnosis for a 30M with chest pain, young, pleuritic, relieved leaning forward?
Pericarditis. ## Footnote ECG: Diffuse ST elevation, PR depression. Rx: NSAIDs + colchicine.
478
246. What is the diagnosis for a 40M with rapid onset testicular pain and absent cremasteric reflex?
Testicular torsion. ## Footnote Rx: Immediate surgical detorsion.
479
247. What is the diagnosis for a 7M with barking cough, stridor, and fever?
Croup. ## Footnote Rx: Dexamethasone ± nebulized epinephrine.
480
248. What is the diagnosis for a 65M with dysphagia for solids then liquids and weight loss?
Esophageal cancer. ## Footnote Test: Endoscopy + biopsy.
481
249. What is the diagnosis for a 6M with eczema, thrombocytopenia, and recurrent infections?
Wiskott–Aldrich syndrome (X-linked). ## Footnote Triad: Eczema, low platelets, infections.
482
250. What is the diagnosis for a 40M with multiple duodenal ulcers, refractory, and diarrhea?
Zollinger-Ellison syndrome (gastrinoma). ## Footnote Test: Fasting gastrin, secretin stimulation test.
483
What is the treatment for hypothyroidism in pregnancy?
Levothyroxine (increase dose by ~30% once pregnancy confirmed).
484
What is the target TSH in pregnancy?
First trimester: <2.5 mIU/L; Second/Third: <3.0 mIU/L.
485
What must you rule out in acute chest pain?
ACS/MI, PE, Aortic dissection, Tension pneumothorax, Pericarditis, Esophageal rupture.
486
What is first-line management in suspected ACS?
MONA: Morphine (if pain), Oxygen (if hypoxemic), Nitrates (unless RV infarct or PDE5), ASA.
487
Criteria for admission in COPD exacerbation?
Severe dyspnea, O₂ sat <90% on RA, confusion, hemodynamic instability, inadequate response to outpatient therapy.
488
First-line outpatient antibiotic for COPD exacerbation?
Amoxicillin or Doxycycline (depending on local resistance).
489
Main differentials for recurrent wheeze in children?
Asthma, Viral bronchiolitis, Foreign body, GERD, CF, Congenital airway anomaly.
490
First-line diagnostic test in >6 yrs suspected asthma?
Spirometry: FEV1/FVC <0.8 with reversibility >12%.
491
What are the 2 most common causes of acute pancreatitis?
Gallstones, Alcohol.
492
What investigations are diagnostic for acute pancreatitis?
Lipase (3× upper limit normal), CT (if severe/uncertain).
493
Key initial management for acute pancreatitis?
IV fluids (aggressive), pain control, NPO.
494
First-line medication + dose in adult anaphylaxis?
Epinephrine 0.3–0.5 mg IM (1:1000), repeat q5–15 min PRN.
495
What other meds adjunctively for anaphylaxis?
H1 blocker, H2 blocker, corticosteroid, SABA neb, fluids.
496
Screening recommendations in average-risk women for breast cancer?
Mammogram q2y from age 50–74.
497
What are risk factors for breast cancer?
Age, BRCA1/2, family history, nulliparity, early menarche, late menopause, obesity, alcohol.
498
Clinical signs of severe dehydration in children?
Sunken eyes, delayed cap refill, tachycardia, weak pulse, lethargy, no tears, oliguria.
499
IV fluid bolus in child for dehydration?
NS 20 mL/kg.
500
3 features of mania in bipolar disorder?
Elevated mood, decreased need for sleep, pressured speech, grandiosity, distractibility, risky behaviors.
501
First-line pharmacotherapy for bipolar disorder?
Lithium, Valproate, or Atypical antipsychotic.
502
When to initiate treatment in adults <60 for hypertension?
≥140/90 mmHg.
503
First-line medications in non-Black, non-diabetic for hypertension?
Thiazide, ACEi/ARB, CCB.
504
First-line treatment in mild pediatric asthma exacerbation?
SABA (salbutamol) via MDI + spacer.
505
Admission criteria for pediatric asthma exacerbation?
O₂ sat <92%, unable to speak/feed, exhaustion, poor response after 3 nebs.
506
Radiographic features of osteoarthritis?
Joint space narrowing, osteophytes, subchondral sclerosis, cysts.
507
First-line management for osteoarthritis?
Weight loss, exercise, acetaminophen/NSAIDs PRN, PT.
508
Classic triad of DKA?
Hyperglycemia, Ketosis, Metabolic acidosis.
509
Most important initial step in DKA?
IV fluids.
510
When do you start insulin in DKA?
Once K⁺ >3.3 mmol/L.
511
Indications for statin in primary prevention (Canada)?
LDL ≥5 mmol/L, Framingham >20%, diabetes >40y or >30y with >15y duration, CKD.
512
Target LDL for dyslipidemia?
<2 mmol/L or ≥50% reduction.
513
First-line investigation for pediatric UTI?
Urine culture (catheter or suprapubic in <3y).
514
Imaging if recurrent pediatric UTI?
Renal/bladder US ± VCUG.
515
STEMI reperfusion options?
PCI within 90 min or fibrinolysis if <12h from onset and PCI not available <120 min.
516
Contraindication to fibrinolysis?
Prior ICH, ischemic stroke <3mo, active bleed, suspected aortic dissection.
517
5 risk factors for geriatric falls?
Polypharmacy, vision impairment, neuropathy, environmental hazards, orthostatic hypotension, balance/gait disorder.
518
Best prevention strategy for geriatric falls?
Multifactorial: exercise, review meds, home safety, vision/hearing correction.
519
Empiric Abx <1 mo for pediatric meningitis?
Ampicillin + Cefotaxime.
520
Empiric Abx >1 mo for pediatric meningitis?
Ceftriaxone + Vancomycin.
521
Classic lab findings for iron deficiency anemia?
↓Hb, microcytosis, hypochromia, ↓ferritin, ↑TIBC.
522
Treatment for iron deficiency anemia?
Oral iron 3–6 mg/kg/day; reassess in 4–6 weeks.
523
Timeline of alcohol withdrawal?
Tremor (6h), hallucinations (12–24h), seizures (24–48h), DTs (48–72h).
524
First-line management for alcohol withdrawal?
Benzodiazepines (symptom-triggered).
525
Diagnostic test for gout?
Joint aspiration → negatively birefringent, needle-shaped urate crystals.
526
Acute treatment for gout?
NSAIDs, Colchicine, or Steroids.
527
First 2 questions of PHQ-2 for depression?
“Over the last 2 weeks, have you felt down, depressed, or hopeless?” “Over the last 2 weeks, have you had little interest or pleasure in doing things?”
528
First-line pharmacotherapy for depression?
SSRI.
529
First-line management of status epilepticus in pediatric seizure?
Lorazepam 0.1 mg/kg IV (max 4 mg).
530
If no IV access in status epilepticus?
Midazolam IM/IN or Diazepam PR.
531
Screening guideline for AAA in men?
One-time abdominal US in men 65–80 who have ever smoked.
532
Indication for surgery in AAA?
≥5.5 cm or rapid growth >0.5 cm/6 mo or symptomatic.
533
Centor criteria components for pediatric pharyngitis?
Tonsillar exudate, tender anterior LAD, fever, absence of cough.
534
First-line treatment if positive strep in pediatric pharyngitis?
Penicillin V or Amoxicillin.
535
NYHA class III definition for CHF?
Symptoms with minimal activity but comfortable at rest.
536
Medications proven to reduce mortality in HFrEF?
ACEi/ARB/ARNI, Beta-blocker, MRA, SGLT2i.
537
Canadian CT Head Rule high-risk criteria?
GCS <15 at 2h, suspected open/depressed skull fracture, basal skull signs, vomiting ≥2, age ≥65.
538
Next step if suspected cervical spine injury?
Immobilize and CT C-spine.
539
Classic signs of hypocalcemia?
Chvostek, Trousseau, paresthesia, seizures, tetany, QT prolongation.
540
Causes of hypocalcemia?
Hypoparathyroidism, Vit D deficiency, CKD, hypomagnesemia.
541
What is the work-up for pediatric fever <1 mo?
Full sepsis work-up: CBC, blood culture, urine culture, LP, CXR if resp.
542
Empiric antibiotics for pediatric fever <1 mo?
Ampicillin + Gentamicin/Cefotaxime.
543
At what age to start cervical cancer screening?
25 (Canada).
544
Screening interval for cervical cancer?
q3y if normal.
545
Classic presentation triad of epiglottitis?
Drooling, Dysphagia, Distress (tripod, stridor).
546
First step in management of epiglottitis?
Secure airway (intubation in OR).
547
Most important surgical causes of pediatric abdominal pain?
Appendicitis, Intussusception, Malrotation/volvulus.
548
Initial investigation for pediatric abdominal pain?
Abdominal US.
549
CURB-65 components for pneumonia?
Confusion, Urea >7, RR ≥30, BP <90/60, Age ≥65.
550
Outpatient first-line antibiotics for pneumonia?
Amoxicillin or Doxycycline.
551
First-line medications for BPH?
Alpha-blocker (tamsulosin), 5-ARI (finasteride).
552
Red flag needing urology referral for BPH?
Hematuria, recurrent UTIs, renal impairment, retention.
553
Causes of hyperthyroidism?
Graves, Toxic multinodular goiter, Toxic adenoma, Thyroiditis.
554
First-line symptomatic management for hyperthyroidism?
Beta-blocker (propranolol).
555
Diagnostic features of pediatric otitis media?
Bulging TM, erythema, loss of landmarks, decreased mobility.
556
First-line antibiotic for pediatric otitis media?
Amoxicillin 80–90 mg/kg/day.
557
tPA window for stroke?
<4.5h from onset if eligible.
558
Contraindications for tPA?
Recent ICH, surgery, bleeding disorder, BP >185/110 uncontrolled, stroke <3 mo.
559
3 categories of causes for acute kidney injury?
Pre-renal (hypoperfusion), Intrinsic (ATN, GN), Post-renal (obstruction).
560
First test to differentiate causes of acute kidney injury?
Urine electrolytes, US for obstruction.
561
Red flag symptoms needing endoscopy for GERD?
Dysphagia, odynophagia, GI bleed, anemia, weight loss, persistent vomiting.
562
First-line management for GERD?
Lifestyle + PPI trial.
563
Gold standard diagnostic for peripheral artery disease?
ABI <0.9.
564
First-line management for peripheral artery disease?
Smoking cessation, exercise, statin, ASA.
565
First-line treatment for pediatric constipation?
PEG 3350.
566
Red flags for pediatric constipation?
Delayed meconium, FTT, neuro deficits, ribbon stools, bloody stools.
567
What is the initial screening test for HIV?
HIV ELISA (antigen/antibody).
568
What is confirmatory for HIV?
Western blot or nucleic acid test.
569
Red flag features for syncope?
Syncope on exertion, during supine, family history of SCD, palpitations, abnormal ECG.
570
First-line investigation for syncope?
ECG.
571
Typical findings in rheumatoid arthritis?
Symmetric polyarthritis, morning stiffness >1h, MCP/PIP joints.
572
First-line DMARD for rheumatoid arthritis?
Methotrexate.
573
Causes of microcytic anemia in pediatric population?
Iron deficiency, thalassemia, lead poisoning, chronic disease.
574
First-line investigation for pediatric anemia?
Ferritin.
575
Classic symptoms of appendicitis?
Periumbilical pain → RLQ, anorexia, fever, nausea.
576
Best initial test in children for appendicitis?
Abdominal US.
577
Most important symptom of endometrial cancer?
Postmenopausal bleeding.
578
Investigation for endometrial cancer?
Endometrial biopsy.
579
First-line abortive treatment for migraine?
NSAID ± Triptan.
580
Indications for prophylaxis in migraine?
≥4 migraines/month, significant disability.
581
First-line treatment for uncomplicated UTI in adult women?
Nitrofurantoin x5d, TMP-SMX x3d, or Fosfomycin x1.
582
When to culture for UTI?
Atypical symptoms, recurrent, pregnant, male, complicated.
583
At what age does a child walk independently?
12–15 mo.
584
At what age does a child use 2-word phrases?
2 yrs.
585
At what age does a child ride a tricycle?
3 yrs.
586
At what age does a child copy a circle?
3 yrs.
587
At what age does a child hop on 1 foot?
4 yrs.
588
At what age does a child tie shoes?
5 yrs.
589
Red flags in developmental milestones?
No head control by 6 mo, No sitting by 9 mo, No walking by 18 mo, No words by 18 mo, No 2-word phrases by 2 yrs
590
First-line workup for developmental delay?
Hearing test, vision screen, thyroid, CBC, ferritin, lead level.
591
Symptoms of Obstructive Sleep Apnea (OSA)?
Loud snoring, witnessed apnea, daytime somnolence, morning headaches, poor concentration.
592
First-line management for OSA?
CPAP + weight loss.
593
Definition of postpartum hemorrhage?
>500 mL after vaginal delivery, >1000 mL after C-section.
594
4 T’s causes of postpartum hemorrhage?
Tone (atony), Tissue (retained), Trauma (laceration), Thrombin (coagulopathy).
595
First-line management for postpartum hemorrhage?
Uterine massage, oxytocin, IV fluids, tranexamic acid.
596
Most common cause of peripheral neuropathy?
Diabetes mellitus.
597
Initial workup for peripheral neuropathy?
CBC, glucose/A1C, B12, TSH, SPEP/UPEP.
598
Most common cause of pediatric bronchiolitis?
RSV.
599
Treatment for pediatric bronchiolitis?
Supportive (O₂, hydration, suction). ❌ No antibiotics/steroids.
600
Admission criteria for pediatric bronchiolitis?
<6 mo, O₂ sat <90%, apnea, poor feeding, dehydration.
601
Canadian C-spine Rule: when to image?
Age ≥65, Dangerous mechanism, Paresthesias in extremities, Inability to rotate neck 45°, Midline tenderness.
602
Best test for cervical spine trauma?
CT C-spine.
603
Differential diagnosis for acute stridor in a child?
Croup, Epiglottitis, Foreign body, Bacterial tracheitis, Anaphylaxis.
604
First-line treatment in croup?
Dexamethasone PO/IM; nebulized epinephrine if severe.
605
Reversible causes of dementia?
Hypothyroidism, B12 deficiency, depression, NPH, syphilis, alcohol.
606
First-line pharmacotherapy for Alzheimer’s?
Cholinesterase inhibitors (donepezil, rivastigmine).
607
Symptoms of acute severe hyponatremia?
Headache, nausea, seizures, coma.
608
Key step in management of hyponatremia?
Correct slowly unless seizures (then hypertonic saline 3%).
609
Red flags for pediatric headache?
Night waking, early morning vomiting, neuro deficit, seizures, personality change, rapid progression.
610
Initial imaging if concerning for pediatric headache?
MRI brain.
611
First-line test for thyroid nodule?
TSH.
612
Suspicious ultrasound features for thyroid nodule?
Microcalcifications, hypoechogenicity, irregular margins, taller-than-wide.
613
Gold standard diagnostic for thyroid nodule?
FNA.
614
Innocent murmur features in pediatrics?
Soft, systolic, musical, changes with position, no symptoms.
615
When to refer for pediatric murmur?
Diastolic, harsh, loud, cyanosis, abnormal pulses, poor growth.
616
Definition of hypertensive emergency?
BP >180/120 + end-organ damage (encephalopathy, MI, AKI, pulmonary edema).
617
Management of hypertensive emergency?
IV antihypertensive (labetalol, nitroprusside). Lower MAP by ≤25% in first hour.
618
Rotterdam criteria for polycystic ovarian syndrome?
Oligo/anovulation, hyperandrogenism, polycystic ovaries on US.
619
First-line management for polycystic ovarian syndrome?
Weight loss, OCPs for menstrual regulation, metformin if insulin resistant.
620
First-line management for pediatric epistaxis?
Pinch nostrils leaning forward for 10–15 min.
621
Adjunct if recurrent pediatric epistaxis?
Silver nitrate cautery, saline spray, treat allergies.
622
Medications to start after ischemic stroke?
ASA (or clopidogrel), statin, ACEi/ARB, manage DM/HTN.
623
When to anticoagulate if Afib after stroke?
Usually within 4–14 days (depending on size/severity).
624
Differential diagnosis for pediatric limp by age?
Toddler (1–3y): Septic arthritis, transient synovitis; Child (4–10y): Legg-Calvé-Perthes; Adolescent: SCFE.
625
First test in suspected septic arthritis?
Joint aspiration (cell count, culture).
626
Jones major criteria for rheumatic fever?
Carditis, polyarthritis, chorea, erythema marginatum, subcutaneous nodules.
627
First-line management for rheumatic fever?
Penicillin + NSAID.
628
First-line treatment for depression in adolescents?
CBT ± SSRI (fluoxetine).
629
Key safety step in adolescent depression?
Suicide risk assessment.
630
Medications for symptom control in end-of-life care?
Morphine (dyspnea/pain), Haloperidol (delirium/nausea), Lorazepam (anxiety), Glycopyrrolate/Scopolamine (secretions).
631
What is MOST important in advance care planning?
Explore patient’s values/goals and align treatment.