Ceftriaxone

Question 1

Ceftriaxone - Type

Answer 1

3rd generation cephalosporin antibiotics

Question 2

Ceftriaxone - Presentation

Answer 2

1g ceftriaxone powder for reconstitution

Question 3

Ceftriaxone - Actions (2)

Answer 3

1. Broad spectrum antibiotic - especially effective against gram-negative bacteria
2. Effective crossing of blood brain barrier

Question 4

Ceftriaxone - Use

Answer 4

Suspected meningoccal disease, in acutely ill patients

Question 5

Ceftriaxone - Adverse effects (3)

Answer 5

1. Hypersensitivity reactions (not common)
2. Diarrhoea
3. Skin rash

Question 6

Ceftriaxone - Contraindication

Answer 6

Known sensitivity to cephalosporins

Question 7

Ceftriaxone - Precaution

Answer 7

It is possible that 20% patients with penicillin allergy may be sensitive to ceftriaxone

Question 8

Ceftriaxone - Dose

Answer 8

Adult & Paediatric - 50mg/kg to a total of 2g (40kg)
Make up to 10ml with normal saline, give over 2-4 minute.
May be given IM (if over 1g give in 2 doses)