Naloxone

Question 1

Naloxone - Type

Answer 1

Narcotic antagonist

Question 2

Naloxone - Presentation

Answer 2

varies frequently (400mcg or 800mcg usually)

Question 3

Naloxone - Action

Answer 3

Reverses the effects of narcotic analgesics
IV onset 1-2 mins, duration 30-45 mins
IM timing unknown

Question 4

Naloxone - Uses (3)

Answer 4

1. Coma
2. Drug overdose and poisoning
3. Use in situations where there is significant decrease in level of consciousness; where there is hypoventilation and/or loss of protective reflexes; and where overdose of narcotics cannot be positively excluded

Question 5

Naloxone - Adverse effects (3)

Answer 5

1. May precipitate acute withdrawal syndrome in narcotic addicts
2. Occasional aggressive behaviour following reversal
3. Nausea and vomiting

Question 6

Naloxone - Contraindication

Answer 6

Known hypersensitivity

Question 7

Naloxone - Doses

Answer 7

Adult
 - 1st dose 0.8mg IM
 - 2nd dose 0.8mg IM OR
 - 2nd dose 0.4mg IV increments fast push
 - may repeat IV dose up to 3 times (to max 2mg)
Paediatric
 - 0.01mg/kg IM/IV
 - max 3 x calculated dose

Question 8

Naloxone - Special notes

Answer 8

IV dose may wear off rapidly