Glyceryl Trinitrate

Question 1

Glyceryl Trinitrate - Type

Answer 1

Nitrate smooth muscle relaxant and vasodilator

Question 2

Glyceryl Trinitrate - Presentation

Answer 2

600mcg sub lingual tablets

Question 3

Glyceryl Trinitrate - Actions (2)

Answer 3

1. Arterial and venous dilation
2. Dilation of collateral coronary vessels

Question 4

Glyceryl Trinitrate - Uses (3)

Answer 4

1. Relieve cardiac pain of ischaemic origin
2. Relieve pulmonary oedema
3. Management of autonomic dysreflexia

Question 5

Glyceryl Trinitrate - Adverse effects (4)

Answer 5

1. Hypotension
2. Headache
3. Flushing of skin
4. Occasionally - bradycardia

Question 6

Glyceryl Trinitrate - Contraindications (5)

Answer 6

1. Systolic BP <90
2. HR <50 (not in autonomic dysreflexia pts)
3. Sildenafil (viagra) or Vardenafil (levitra) in past 24 hrs
4. Tadalafil (cialis) in past 3-4 days, 4-5 in elderly and renal impaired
5. known hypersensitivity

Question 7

Glyceryl Trinitrate - Notes

Answer 7

Tablet should fizz under tongue

Use within 3/12 of bottle opening - must be dated

Question 8

Glyceryl Trinitrate - Doses

Answer 8

Chest pain

Adult - 600mcg S/L

• 300mcg S/L if sBP 90-100 or not normal med.

Repeat initial dose x 1 if req

Acute APO

Adult - 600mcg S/L

• 300mcg S/L if sBP 90-100 or not normal med.

Repeat initial dose x 1 if req

Autonomic dysreflexia

Adult - 300mcg S/L

Paediatric (12-16yrs) - 150mcg S/L

If little/no effect repeat x 2 as req at 5/60.