At altitude, the homeostasis of which essential variable is disturbed? What are the acute and chronic altitude illnesses are the consequences of the failure to maintain oxygen homeostasis?
O2 levels, acute illnesses: AMS, High altitude cerebral edema, High altitude Pulmonary Edema. Chronic illness: CMS
How do the altitude illnesses differ from inflammatory or immune system sources of pathophysiology?
its a disturbance to our homeostasis, not and injury or an infection. Normal because we are alive
Compare general functions of the inflammatory and immune systems>
inflammation: injury invasion response
Immune: defend against pathogens
Describe the three inflammatory processes
mobilize: activates immune and repair systems
organize: isolate and prepare area for repair
remodeling: depending on damage, the area is either regenerated or replaced
Describe the three levels of immune protection
protective barriers: physical and chemical defenses (Skin, pH, etc.)
Innate immunity: phagocytes and microphages seek to destroy all invaders, good or bad
Acquired-adaptive immunity: killer cells trained to identify pathogens, antibodies (memory cells that train to fight and infection for the next time)
If inflammation is designed to mobilize the response to injury and infections how might it cause more damage?
The system isn’t 100% perfect and can target healthy cells unintentionally.
If you didn’t have the ability to fight infection, how might your life change?
You would have to be super careful around crowds, extremely hygienic, and create an environment that reflects that.
What are some normal situations of immunosuppression?
pregnancy, aging, certain medications
What are some abnormal situations of immunosuppression?
allergies, anaphylaxis, extreme vasodialation
What are some disease of autoimmunity?
Lupus, Chrons, Psoriasis, immune system basically kills itself
What are the three types of prevention? Which is the most cost effective?
Primary: health prevention (diet/exercise)
Secondary: reduces developing disease risk and prevention (BP and cholesterol meds)
Tertiary: restores health and minimizes disease morbidity (cardiac rehabilitator and PT)
