myeloproliferative disorder
4
Philadelphia Ch. +
Philadelphia Ch. -
CML
Polycythaemia vera
Essential thrombocytosis
Myelofibrosis
rarely
Philadelphia Chr.
t(9:22)
t=translocation
BCR:Abl
worse
massive spenomegaly
hepatomegaly
bruising (platelet dysfunction)
chronic/insidious
weight loss
sweats
fever
tired
Raised (>100x10^9/L)
hypercellularity
yes (all myeloid line)
chronic
accelerated
blast transformation
chronic
blast transformation
BCR:Abl gene tyrosine receptor
imatinib
Nilotinib
allogenic HLA matched stem cell transplant
young patients (if risk low)
Older patients