> 96 fL
cell in which the maturation of the nucleus is delayed in comparison to the rest of the cell
delayed maturation of nucleus due to impaired DNA synthesis
megaloblastic
non-megaloblastic
other
hypersegmentation (>5 segments)
serum
Red cell
Blood film
b12/folate testing
4 months
vegetables
gut bacteria
duodenum/proximal jejunum
folic acid 5mg/day 4 months
WITH
B12
folate treatment can worsen B12 deficiency precipitating SACDSC
spina bifida
Homocysteine levels
folate lowers homocysteine levels
cytotoxic drugs
b12 deficiency
folate deficiency
Alcohol
liver disease
hypothyroidism
reticulocytosis
myeloma
aplastic anaemia
myeloproliferative disorders
myelodysplasia