associated with elevated pressure, optic neuropathy
Glaucoma
the only modifiable risk factor for glaucoma
inc IOP
normal IOP
10-21 mmHg
Glaucoma IOP level
higher than 22 mmHg
drainage is completely blocked (open or closed angle)
closed angle
reason for angle closure
maybe due to iris bulging
due to increase resistance of the network that impedes outflow
open angle glaucoma
produces aqueous humor
ciliary body and muscle
most common type in north america
open angle glaucoma
often asymptomatic (open or close)
open angle glaucoma
risk factor due to corticosteroid use, pseudoexfoliation
secondary open angle glaucoma
caused by trabecular meshwork dysfunction
primary open angle glaucoma
this is rare type, due to iris bulging
angle closure glaucoma
to prevent permanent blindness, how long should treatment be provided
within 24 hours
aside from iris bulging, angle closure can be due to what?
diabetes
medication causes of glaucoma
TOPIRAMATA, ANTIDEPRESSANTS, COC, antichol, decongestants, antihistamine
decreases aq humor outflow (dec IOP)
prostaglandin, cholinergic AGONIST, alpha-2 AGONIST
decreases aq humor production
beta blockers, carbonic anhydrase inh
most effective agent in reducing IOP and well tolerated
prostaglandin analogues LATANOPROST, bimatoprost, travoprost
often used as an adjunctive therapy
prostaglandin analogies
how long is latanoprost effective after opening
6 weeks, if not opened should be ref
has long duration of action, and has systemic effects (agent for glaucoma)
beta blockers (timolol is better»> betaxolol)
reserved as a last line option due to tolerability
pilocarpine
side effect of pilocarpine
myopia