Gout

Question 1

after the first gout flare- intercritical gout..what happens

Answer 1

no symptoms

Question 2

drugs causing GOUT

Answer 2

cyclosporines, loop diuretics, thiazides, saliculates

Question 3

first line, acutre gout attacke

Answer 3

NSAIDS, colchicine, corticosteroids

Question 4

SE of colchicine

Answer 4

bone marrow suppression NVD, GI se,(avoid in renal and hepatic impairment)

Question 5

what are the urate lowering therapies

Answer 5

allopurinol, febuxostat

Question 6

given along with ULT

Answer 6

colchicine, NSAIDS, corticosteroids for the first 3-6 montnths (concomittant anti-inflamm prophylaxis therapy)

Question 7

SE of allopurinol

Answer 7

AHS, risk factor of HLA-B*5801, renal impair, thiazide

Question 8

SE febuxostat

Answer 8

CVD-related deaths, but okay for renail impaired

Question 9

drug that cause hyperuricemia

Answer 9

LEVODOPA

Question 10

colchicine, cyp metabolism

Answer 10

colchicine cyp3a4 substrate