Midazolam

Question 1

What is the presentation of Midazolam?

Answer 1

5mg in 1mL

15mg in 3mL

Question 2

What is the pharmacology of Midazolam? List the 3 actions.

Answer 2

Short acting CNS depressant.
Actions:
1. Anxiolytic
2. Sedative
3. Anti-convulsant

Question 3

How is Midazolam metabolised and excreted?

Answer 3

Metabolised by the liver.

Excreted by the kidneys.

Question 4

List the PEI’s for Midazolam.

Answer 4

1. Status epilepticus
2. Sedation to enable intubation
3. Post intubation sedation
4. Sedation to facilitate synch cardioversion
5. Sedation to facilitate transthoracic pacing
6. Sedation in the agitated pt
7. Sedation in psychostimulant OD

Question 5

List the contraindication for Midazolam.

Answer 5

1. Known hypersensitivity to benzodiazepines.

Question 6

List the precautions for Midazolam.

Answer 6

1. Reduced doses may be required for the elderly/frail, pts with chronic renal failure, CCF or shock.
2. CNS depressant effects are enhanced in the presence of narcotics/other tranquilisers including alcohol.
3. Can cause severe respiratory depression in pts with COPD
4. Pts with myasthenia gravis

Question 7

List the side effects of Midazolam.

Answer 7

1. Depressed level of consciousness
2. Respiratory depression
3. Loss of airway control
4. Hypotension

Question 8

List the onset, peak and duration of IM Midazolam.

Answer 8

O: 3 - 5 minutes
P: 15 minutes
D: 30 minutes

Question 9

List the onset, peak and duration of IV Midazolam.

Answer 9

O: 1 - 3 minutes
P: 10 minutes
D: 20 minutes