Misoprostol

Question 1

What is the presentation of Misoprostol?

Answer 1

200mcg tablet

Question 2

What is the pharmacology and 1 action of Misoprostol?

Answer 2

A synthetic prostaglandin.
Action:
1. Enhances uterine contractions.

Question 3

How is Misoprostol metabolised and excreted?

Answer 3

Converted to active metabolite misoprostol acid in the blood, metabolised in the tissues.
Excreted by the kidneys.

Question 4

List the PEI for Misoprostol.

Answer 4

1. Primary postpartum haemorrhage

Question 5

List the contraindications for Misoprostol.

Answer 5

1. Allergy to prostaglandins

2. Exclude multiple pregnancy before drug admin

Question 6

List the precaution for Misoprostol.

Answer 6

1. Hx of asthma

Question 7

List the side effects of Misoprostol.

Answer 7

1. Hyperpyrexia
2. Shivering
3. Abdominal pain
4. Diarrhoea

Question 8

Via what route is Misoprostol administered?

Answer 8

Oral.

Question 9

What is the special note regarding Misoprostol?

Answer 9

1. Side effects are more likely with a >600mcg oral dose.

Question 10

What is the onset and duration of Misoprostol?

*Peak not listed

Answer 10

O: 8 to 10 minutes
D: 2 to 3 hours