Morphine

Question 1

What is the presentation of Morphine?

Answer 1

10mg in 1mL

Question 2

What is the pharmacology for Morphine?

Answer 2

An opioid analgesic.

Question 3

What are CNS and cardiovascular actions of Morphine?

Answer 3

CNS Effects:

1. Depression
2. Respiratory depression
3. Depression of cough reflex
4. Stimulation (changes of mood, euphoria, vomiting, pinpoint pupils)
5. Dependence

CV Effects:

6. Vasodilation
7. Decreases conduction velocity through AV node

Question 4

How is Morphine metabolised and excreted?

Answer 4

Metabolised by the liver.

Excreted by the kidneys.

Question 5

List the PEI’s for Morphine.

Answer 5

1. Pain relief

2. Sedation to maintain intubation

Question 6

List the contraindications for Morphine.

Answer 6

1. Hx of hypersensitivity
2. Renal impairment/failure
3. Late second stage of labour

Question 7

List the precautions for Morphine.

Answer 7

EACHPARK

1. Elderly/frail
2. Hypotension
3. Respiratory depression
4. Current asthma
5. Respiratory tract burns
6. Known addiction to opioids
7. Acute alcoholism
8. Pts on MAOI’s

Question 8

What routes can Morphine be administered via?

Answer 8

IM
IV
Subcutaneous

Question 9

List the side effects of Morphine.

Answer 9

BENDHARP
CNS:
1. Drowsiness
2. Respiratory depression
3. Euphoria
4. Nausea, vomiting
5. Addiction
6. Pin-point pupils

CV:

7. Hypotension
8. Bradycardia

Question 10

List the special notes regarding Morphine.

Answer 10

1. Is an S8 - control with accountability/responsibility.
2. Side effects can be reversed with Naloxone.
3. Wheals may be seen in the vein due to histamine release - this is not an allergy.

Question 11

List the onset, peak and duration for IV Morphine.

Answer 11

O: 2 to 5 mins
P: 10 mins
D: 1 to 2 hours

Question 12

List the onset, peak and duration for IM Morphine.

Answer 12

O: 10 to 30mins
P: 30 to 60mins
D: 1 to 2 hours