Peripheral nervous system

Question 1

Bilateral peripheral schwannomas occur in setting of which germline mutation?

Answer 1

NF2

Question 2

Schwannomatosis is association with which germline mutations (x2)?

Answer 2

1. SMARCB1

2. LZTR1

Question 3

Which ICH would you use to confirm dx of schwannoma? (x2)

Answer 3

Diffuse strong positivity for S100 and SOX10 is characteristic.