Clindamycin

Question 1

Which serious skin reaction requires immediate discontinuation of clindamycin? A. Urticaria B. Stevens–Johnson syndrome C. Photosensitivity D. Acneiform rash E. Eczema

Answer 1

B. Stevens–Johnson syndrome requires immediate discontinuation.

Question 2

A patient develops a widespread blistering rash while taking clindamycin. What is the most appropriate action? A. Reduce the dose B. Continue with antihistamine C. Discontinue clindamycin D. Switch to topical therapy E. Reassure patient

Answer 2

C. Clindamycin must be discontinued due to risk of Stevens–Johnson syndrome.

Question 3

Which antibiotic is strongly associated with Clostridioides difficile–associated diarrhoea? A. Nitrofurantoin B. Doxycycline C. Clindamycin D. Fosfomycin E. Azithromycin

Answer 3

C. Clindamycin is strongly associated with C. difficile infection.

Question 4

Clostridioides difficile–associated diarrhoea linked to clindamycin is more severe in which patient group? A. Children B. Pregnant women C. Elderly patients D. Athletes E. Smokers

Answer 4

C. It is more severe in elderly patients.

Question 5

Which gastrointestinal complication may result from clindamycin use? A. Constipation B. Irritable bowel syndrome C. C. difficile–associated diarrhoea D. Pancreatitis E. Gastritis

Answer 5

C. Clindamycin can cause C. difficile–associated diarrhoea.

Question 6

C. difficile–associated diarrhoea caused by clindamycin can range from mild to which severe outcomes? A. Liver failure B. Peritonitis

Answer 6

shock and toxic megacolon C. Nephrotoxicity D. QT prolongation E. Seizures

Question 7

Which complication of C. difficile infection may be fatal? A. Mild diarrhoea B. Flatulence C. Toxic megacolon D. Constipation E. Dyspepsia

Answer 7

C. Toxic megacolon can be fatal.

Question 8

What should be done if C. difficile infection is suspected in a patient taking clindamycin? A. Reduce dose B. Switch to another antibiotic C. Discontinue clindamycin D. Add antidiarrhoeal medication E. Continue and monitor

Answer 8

C. Clindamycin should be discontinued immediately.

Question 9

What should be done if C. difficile infection is confirmed in a patient taking clindamycin? A. Continue treatment B. Increase fluid intake only C. Discontinue clindamycin D. Add probiotic E. Reduce frequency

Answer 9

C. Clindamycin must be discontinued if C. difficile is confirmed.

Question 10

Which symptom combination would raise concern for severe clindamycin-associated C. difficile infection? A. Mild nausea only B. Diarrhoea with abdominal pain and fever C. Occasional loose stool D. Constipation E. Heartburn

Answer 10

B. Diarrhoea with systemic symptoms suggests severe infection.

Question 11

Which counselling point is MOST important for patients starting clindamycin? A. Avoid dairy products B. Report severe diarrhoea immediately C. Take with grapefruit juice D. Avoid sunlight E. Take before meals

Answer 11

B. Patients must report severe or persistent diarrhoea immediately.

Question 12

Why is clindamycin considered high-risk for antibiotic-associated colitis? A. Causes hypokalaemia B. Alters gut flora significantly C. Causes gastric erosion D. Delays gastric emptying E. Causes dehydration

Answer 12

B. Clindamycin significantly disrupts gut flora

Question 13

Which action is correct if a patient develops diarrhoea during clindamycin therapy? A. Reassure and continue B. Use loperamide C. Assess for C. difficile and discontinue if suspected D. Reduce dose E. Switch to NSAID

Answer 13

C. Diarrhoea should be assessed and clindamycin stopped if C. difficile is suspected.