Gabapentin

Question 1

Brand Name

Answer 1

Neurontin

Question 2

Broad Class

Answer 2

Analgesic Adjunct / Anticonvulsane

Question 3

Class

Answer 3

Gabapentinoid

Question 4

MOA

Answer 4

same as pregabalin except:
blocks Ca2+ channels in dorsal horn preventing glutamate release
Secondary pathway: activates descending noradrenergic pathways in spinal cord and brain

Question 5

Indications

Answer 5

Chronic pain / Neuropathic pain
Epilepsy
Off label: anxiety
Postherpetic neuralgia

Question 6

Preop dose

Answer 6

300-600 mg

Question 7

Post op maintenance dose

Answer 7

1200 mg/day divided doses

Question 8

Onset

Answer 8

1-2 hours

Question 9

Duration

Answer 9

8 - 12 hours

Question 10

Common SE

Answer 10

INCREASES POST OP SEDATION
dizziness
blurred vision
peripheral edema

Question 11

Contraindications / avoidance

Answer 11

advanced age
Renal impairment
Morbidly obese
OSA

Question 12

Metabolism

Answer 12

minimal to none

Question 13

Elimination

Answer 13

Renal excretion unchanged

Question 14

Elim Half-life

Answer 14

5-7 hours

Question 15

Vd consideration

Answer 15

Low-Moderate
- hydrophillic
- active transport into CNS

Question 16

Clearance Considerations

Answer 16

Reduced clearance in
- renal impairment
- elderly