Pancuronium

Question 1

Brand Name

Answer 1

Pavulon

Question 2

Broad Class

Answer 2

long-acting NMDA

Question 3

Pharm class

Answer 3

Aminosteroid

Question 4

Reversal

Answer 4

Neostigmine

Question 5

MOA

Answer 5

Same as other aminosteroids

Question 6

Indications

Answer 6

• intubation (long cases)
• surgical relaxation

Question 7

CV effects?

Answer 7

antimuscarinc effects and increased NE release/ decreased NE reuptake
- tachycardia
- increased BP

Question 8

Histamine release?

Answer 8

No

Question 9

Cardiovascular precautions

Answer 9

patients who cannot tolerate increased CO or HR (AS/CAD, hypertrophic cardiomyopathy, non-cardiac stable patients)

Question 10

Renal precautions?

Answer 10

Heavily relies on renal excretion, prolonged action in renal failure

Question 11

Induction Dosing

Answer 11

0.08 - 0.12 mg/kg

(0.1 mg/kg)

Question 12

Maintenance Dosing

Answer 12

0.01 mg/kg

Question 13

Onset

Answer 13

2-3 mins

Question 14

Duration

Answer 14

60-100 mins

Question 15

Metabolism

Answer 15

Limited hepatic (20%)

Question 16

Active metabolite

Answer 16

3-OH Pancuronium (50% potency)

Question 17

Elimination

Answer 17

Primarily Renal