Morphine

Question 1

What is morphine derived from

Answer 1

opium poppy (Papaver somniferum)

Question 2

Class

Answer 2

Phenantherene opioid agonist - natural opioid

Question 3

Mechanism of action

Answer 3

mu (and kappa according to powerpoint chart) receptor agonist (Gi GCPR)

Question 4

Indications

Answer 4

periop pain management - mostly used in the PACU , can be used in spinal and epidural

Question 5

general pharmacokinetics

Answer 5

Slow onset due to low lipophilicity. duration 4-6 hours.
Low keo

Question 6

what type of pain responds best to morphine

Answer 6

continuous/dull pain

Question 7

Primary metabolic pathway

Answer 7

glucoronidation

Question 8

primary metabolites

Answer 8

M3G (no analgesia) and M6G (stronger analgesia then parent compound)

Question 9

can we give morphine in liver disease patients

Answer 9

sí

Question 10

can we give morphine in renal failiure

Answer 10

no, pts will accumulate M6G = increased risk of resp depression

Question 11

populations to avoid/be cautious in

Answer 11

elderly (more sensitive), neonates (reduced clearance), patients with OSA, renal failure

Question 12

Histamine release?

Answer 12

YUPP- give it slow and can give H1 blocker if needed