Haloperidol

Question 1

Brand Name

Answer 1

Haldol

Question 2

Broad Category

Answer 2

Antipsychotic / Antiemetic

Question 3

Pharmacological Class

Answer 3

First gen antipsychotic / Butyrophenone

Question 4

MOA

Answer 4

Blocks D2 receptors in the basal ganglia and limbic portions of the forebrain

Question 5

Indications / Clinical Uses

Answer 5

PONV
Psychiatric illness (psychoses and Schizophrenia)
Agitation

Question 6

Antiemetic dosing

Answer 6

1-2 mg IV

Question 7

Onset

Answer 7

3-10 mins

Question 8

Duration

Answer 8

4-8 hours

Question 9

CV effects

Answer 9

QT prolongation

Question 10

CNS effects

Answer 10

EPS
- tardive dyskinesia

Question 11

Endocrine effects

Answer 11

Hyperprolactinemia
Sexual Dysfunction

Question 12

Other Concerns?

Answer 12

Neuroleptic Malignant Syndrome

Question 13

Metabolism

Answer 13

Extensive Hepatic
- CYP3A4
- CYP2D6

Question 14

Elimination

Answer 14

Renal
Biliary

Question 15

Vd considerations

Answer 15

Very large
- highly lipophillic
- extensive tissue distribution
- crosses BBB

Question 16

Protein binding

Answer 16

High (90-92%)

Question 17

Clearance Considerations

Answer 17

Reduced clearance with
- Hepatic impairment
- CYP enzyme inhibition

Question 18

Absolute Contraindications

Answer 18

Parkinson’s
Hypersensitivity
Severe CNS depression / sedation
QT prolongation

Question 19

Precautions

Answer 19

History of NMS
Hepatic impairment
Elderly dementia pts (increased mortality risk)