Top Drawer - syd > Scopolamine > Flashcards

Scopolamine Flashcards

(23 cards)

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1
Q

Broad Class

A

Antisialagogue
Antivertigo

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2
Q

Pharm class

A

Anticholinergic / Antimuscarinic

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3
Q

Structural Considerations

A

Tertiary Amine
Naturally occuring belladonna alkaloid

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4
Q

MOA

A

Primary Action: Competetive antagonist of ACh at parasympathetic muscarinic receptors

Also antagonizes histamine and serotonin

Effects on vestibular apparatus

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5
Q

Indications / Clinical Uses

A

Decreases secretions
PONV
motion sickness/vertigo
dilate pupils and cycloplegia
unstable trauma pt
sedation/amnesia

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6
Q

Dosing IV/IM

A

0.3 - 0.65 mg (both)

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7
Q

Trandermal patch dosing

A

1 mg postauricular

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8
Q

IV onset

A

1-3 mins

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9
Q

IM onset

A

30-60 mins

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10
Q

Transdermal onset

A

2-3 hours

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11
Q

IV duration

A

30-60 mins

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12
Q

IM duration

A

4-6 hours

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13
Q

CV effects

A

Paradoxical: may decrease HR (especially low doses 0.1 - 0.2 mg)

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14
Q

CNS

A

Depressant effects
amnesia
toxic psychosis (especially in elderly)
dizziness
Mydriasis
blurred vision (cycloplegia)
anisocoria (different pupil sizes)

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15
Q

Patch teachings?

A

Take off patch in 24 hours, wash hands, and DO NOT touch eyes

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16
Q

Contraindications

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A

Narrow-angle glaucoma

17
Q

Population considerations: Elderly

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A

Toxic psychosis

18
Q

Primary Concern

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A

Anticholinergic Syndrome (Treat with Physo)

19
Q

Drug-Drug interactions

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A

Opioids increase vestibular sensitvity thus counteracting therapeutic antivertigo effect

20
Q

Metabolism

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A

Primarily Liver
- hydrolysis and conjugation

21
Q

Elimination

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A

Primarily: Renal
- 90% in urine
- small amount excreted unchanged

minor biliary excretion

22
Q

Elimination Half-life

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A

2-4 hours
- CNS effects may persist longer due to central receptor binding and redistribution

23
Q

Clearance Rate

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A

1.2-1.5 L/min

High Hepatic ER

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