Toradol

Question 1

Brand Name

Answer 1

Ketorolac

Question 2

Broad Category

Answer 2

Analgesic / Anti-inflammatory / Nonopioid adjunct

Question 3

Pharmacological class

Answer 3

NSAID
nonselective COX-1 and COX-2 inhibitor

Question 4

MOA

Answer 4

Inhibits COX, preventing the synthesis of prostaglandins (including thromboxane) acting peripherally (No BBB crossing)

Question 5

Indications / Clinical uses

Answer 5

Decrease pain and cramping
Postop Cesarean
orthopedics
laparoscopy
Decreases narcotic use postop

Question 6

IV Dose

Answer 6

15 - 30 mg

Question 7

Onset

Answer 7

10-30 minsur

Question 8

Peak

Answer 8

1-2 hours

Question 9

Duration

Answer 9

4-6 hours

Question 10

Hematologic effects

Answer 10

inhibits platelet aggregation and prolongs bleeding time

Question 11

GI effects

Answer 11

Ulceration / GI bleed

Question 12

GU effects

Answer 12

Long-term admin –> renal toxicity (papilary necrosis)

Question 13

Absolute Contraindications

Answer 13

Renal impairment / poor creatinine clearance
active bleeding
GI dysfunction

Question 14

Precautions

Answer 14

Elderly
ASA allergy
Asthma
nasal polyps

Question 15

What is samter’s triad

Answer 15

asthma, nasal polyposis, and ASA allergy
- AKA Aspirin exacerbated Respiratory Disease
- NSAIDs can trigger severe acute respiratory reactions

Question 16

What must you do before giving

Answer 16

Always ask the surgeon

Question 17

30 mg IV is equal to how many miligrams of morphine

Answer 17

10 mg morphine

Question 18

Metabolism

Answer 18

Partial hepatic

Question 19

Elimination

Answer 19

Renal
- 60% excreted unchanged

Question 20

Vd considerations

Answer 20

Low
- Remains intravascular and extracellular compartments

Question 21

Clearance Considerations

Answer 21

Reduced in
- Renal dysfunction
- Elderly

Question 22

Protein binding

Answer 22

Very high (99%)