What is the therapeutic goal of transfusions
Temporary tissue transplant
Supportive NOT definitive therapy
What is the primary colloid in the body and where is it found
Albumin in the plasma
What is the main potential hazard of transfusions
Immune system response
What are the indications for blood transfusion (3)
Acute blood loss (trauma or surgery)
Anemia
Hemostasis (decreased platelet numbers, von willebrands)
What clinical parameters can you use to check if transfusion is needed (8)
PCV
TP
Pulse pressure
Respiratory character
MM color/CRT
Urine production
CVP
Arterial blood gases
Why should PCV alone not be used to check for acute blood loss
Can be normal for up to 6 hours after loss due to the time it takes for fluids to equilibrate
Which type of container should blood be stored in
Plastic
Platelets hate glass :(
What are the components of blood that can be used in a transfusion (3)
Fresh whole blood
Packed RBC
Plasma
When should packed RBC be used
Anemia only
When should fresh frozen plasma be used
When albumin in needed
To help with clotting
Where can you find blood donors
Veterinary colleges
Employee/clinic pets
Outpatient donors
What is the main canine blood group
Dog erythrocyte antigen (DEA)
How many blood groups are there by international standards, what are they
8
1.1, 1.2, 3, 4, 5, 6, 7, 8
Which DEA group is most critical
1.1
& 1.2 to lesser extent
What are alloantiboides
Naturally occurring antibodies to RBC antigens
T/F dogs can be both DEA 1.1 and 1.2 positive
FALSE. If they are DEA 1.1 + they cannot be DEA 1.2 + & vice versa
T/F dogs cannot be given a blood transfusion without being typed first
FALSE - can be given first transfusion, but must be tested after that
What will happen if you give a DEA - dog DEA + blood
Nothing the first time, but after first time will become sensitized
Why can dogs get first transfusion with no concern
Dogs have no inherent alloantibodies against DEA 1.1
What happens during a transfusion reactions
Immunogenic response between antigen & antibody
What happens if a DEA - dog is given + blood after already being sensitized
Acute hemolysis within minutes to hours
how long do RBC live for
120 days
What is neonatal isoerythrolysis
DEA 1.1 - mom that has been sensitized is bred with DEA 1.1 + dad & puppies come out DEA 1.1 +
When puppy nurses colostrum they ingest the DEA 1.1 + antibodies that begin to attach their own blood
What are the feline blood groups
A
B
AB