cytokines
soluble proteins that act on cells to activate and regulate the immune system
chemokine
proteins that attract specific immune cells to site of infection via chemotaxis
TLR recognizes what
proteins, nucleic acids, glycans
CLR recognizes what
recognizes carbohydrates / sugars
NLRs recognize what
parasites or fungi
RLR recognizes what
viral RNA
what does cGAS detect
dsDNA
what does IFN production do
induces an antiviral state in adjacent cells
what induces type 1 IFN
induced by PAMPs binding PRRs
antiviral states (2)/ genes that IFN 1 produce when they bind
OAS - RNAase L
PKR - phosphorylates eIF2a
what is pre arming
ready to go RKR and OAS by the cell but they are laying inactive. the activation only happens when there’s an infection of dsRNA that leads to immediate shutdown of translation machinery
pro inflammatory cytokines
IL-6, 1, and TNF
NK cells are activated by what
type 1 IFN, Il-12
what cells can produce MHC II
macrophages/ dentritic cells
what does production of IFN 1 do (3)
initiate antiviral state
enhance DC maturation
activate NK cells to enhance CD8 activity
when Rb is bound ?
inhibition of translation
potential outcomes of a viral infection (3)
acute infection
persistent symptomatic or asymptomatic
latent (recurring during stress)
