Antigen Processing

Question 1

CD4

Answer 1

CD4 binds to MHC-II on APC presenting peptides to T-helper cells.

Question 2

CD8

Answer 2

surface molecule expressed by mature Cytotoxic T lymphocytes. Binds to MHC-I on infected host/tumor cell and presents peptides to CTL

Question 3

Cytotoxic T-Lymphocyte (CTL)

Answer 3

Kill host infected/tumor cells. Host cell must present appropriate MHC complex

Question 4

Host infected cells presented to CTLs

Answer 4

presents microbial and tumor antigen fragments to CTL

Question 5

Major Histocompatibility Complex (MHC)

Answer 5

Gene region that contains genes for the major histocompatibility molecules. Encode for MHC-1 and MHC-2

Question 6

MHC-1

Answer 6

expressed by any host infected or host tumor cell w/ nucleus. Required for presenting peptides to CTLs. Will process viral proteins and insert peptides of these proteins into MHC molecules + shuttle them to the surface for peptide presentation.

Question 7

MHC-2

Answer 7

MHC molecules expressed by pro/semi APC. Required for presenting peptides to T-helper cells.

Question 8

MHC molecules

Answer 8

Proteins coded for by genes in MHC. enable APCS to present antigens to T-lymphocytes

Question 9

Peptides

Answer 9

Short chains of amino acids that can be involved in the Complement cascade. Protein antigens need to be broken down into peptides units to be presented to T-lymphocytes

Question 10

Pro/semi Pro Antigen Presenting cells (APCs)

Answer 10

take up protein antigens from ECM, process into peptides and present to T-helper cells.

Question 11

T-Cell receptor

Answer 11

Antigen receptor expressed by T-Lymphocytes. Site of location of antigen peptide binding to MHC molecules.

Question 12

T-helper Lymphocytes

Answer 12

When Activated by antigen presenting it to APCs, produces cytokines that help B and CTLs

Question 13

T Lymphocytes

Answer 13

lymphocytes that express T-cell receptors for antigen and are responsible for cell-mediated component of Adaptive Immune Response.