B & T cell development

Question 1

B lymphocytes are

Answer 1

Lymphocytes that express B-Cell
Receptors for antigen and are
responsible for antibody
production. B-cells can also act
as a semi-pro AOC. B-cells are
cells of the Adaptive Immune
system

Question 2

T- Lymphocytes

Answer 2

Lymphocytes that express T-Cell
Receptors for antigen and are
responsible for the cell-
mediated component of the
Adaptive Immune response. T-
cells are part of the Adaptive
Immune system

Question 3

Bone Marrow

Answer 3

soft, spongy tissue in medullary cavities of bones

Question 4

Thymus

Answer 4

Gland in the lymphatic system where T lymphocytes undergo maturation and acquire their unique TCR

Question 5

Naive Lymphocyte

Answer 5

Mature lymphocyte that has not yet interacted with its particular antigen, the antigen that its antigen receptor recognizes

Question 6

Primary Lymphoid tissues

Answer 6

tissues that provide an environment for lymphoid stem cells to replicate and mature into B & T cells

Question 7

Secondary lymphoid tissues

Answer 7

provide environment for B + T cells to encounter antigen

Question 8

BCR

Answer 8

antigen receptor on B cells

Question 9

TCR

Answer 9

antigen receptor on T lymphocytes

Question 10

Plasma cell

Answer 10

Differentiated B lymphocyte capable of making and secreting antibodies

Question 11

CD4 (cluster of differentiation)

Answer 11

Surface molecule expressed by mature T-helper cells. CD4 binds MHC II on the antigen presenting cell presenting peptides to T-helper cells.

Question 12

CD8

Answer 12

surface molecule expressed by mature CTLs. CD8 binds MCH I on infected host cell

Question 13

Epitope

Answer 13

part of an antigen that is recognized by host immune cells

Question 14

Facultative extracellular/intracellular microbe

Answer 14

Microbes that can replicate both outside and inside of host cells

Question 15

MHC

Answer 15

Genes that code for MHC I and MCH II

Question 16

Peptides

Answer 16

short chains of 2+ amino acids. Protein antigens first need to be broken down into peptide units

Question 17

Polyclonal antibody

Answer 17

collection of antibodies from multiple B cell clones.

Question 18

TCR

Answer 18

antigen receptor expressed by T lymphocytes. TCR binds its peptide of interest and self MHC molecules.

Question 19

T helper Lymphocyte

Answer 19

differentiated T lymphocyte that when activated by antigen presentation to it by pro/semi pro APCS. Produces Cytokines