Breast

Question 1

mutation in flat epithelial atypia, LG DCIS, ADH, lobular

Answer 1

deletion of ch 16q

Question 2

cystic neutrophilic granulomatous mastitis

Answer 2

Corynebacterium

Question 3

lymphocytic mastopath/sclerosi na lymphocytic lobulitis

Answer 3

DM type 1 female

Question 4

function of BRCA 1/2

Answer 4

tumor suppressor genes

Question 5

HER2 amplification in what chromosome

Answer 5

17q

Question 6

Luminal pathway

Answer 6

BRCA2 - 1q gain, 16q loss - FEA - PIK3CA - ADH - DCIS - ER positive, HER2 neg

Question 7

HER2 positive pathway

Answer 7

TP53, HER2 amp - DCIS - HER2 positive

Question 8

Basal/TNBC pathway

Answer 8

BRCA1 mutation, TP53 - BRCA1 inactivation - DCIS - TNBC

Question 9

HER2 IHC stain in Paget cells

Answer 9

positive

Question 10

mutation in male breast CA

Answer 10

BRCA2

Question 11

additional mutation in malignant phyllodes

Answer 11

TERT

Question 12

mutation in HG DCIS

Answer 12

17q loss

Question 13

ETV6-NTRK3 mutations

Answer 13

secretory CA
infantile fibrosarcoma
cellular variant congenital mesoblastic nephroma

Question 14

mitotic count field diameters for
0.44
0.59
0.63

Answer 14

6-10
10-19
12-22

Question 15

post-radiation angiosarcoma mutation

Answer 15

MYC

Question 16

masson tumor

Answer 16

intravascular papillary endothelial hyperplasia