KUB

Question 1

nephritic syndrome

Answer 1

hematuria, azotemia, variable proteinuria, oliguria, edema, HTN

Question 2

nephrotic syndrome

Answer 2

> 3.5g/day proteinuria, hypoalbuminemia, hyperlipidemia, lipiduria

Question 3

subepi hump

Answer 3

PSGN

Question 4

subepi deposits (spikes and domes)

Answer 4

membranous nephropathy

Question 5

mesangial deposits

Answer 5

IgA nephropathy
C3 glomerulopathy
early lupus nephritis

Question 6

subendo deposits, tram track

Answer 6

MPGN
lupus nephritis

Question 7

crescentic/RPGN types

Answer 7

I - anti-GBM Ab mediated (Goodpasture)
II - immune complex mediated
III - pauci-immune (ANCA)

Question 8

membranous nephropathy antigen

Answer 8

PLA2R

Question 9

Ab in minimal change and FSGS

Answer 9

anti-nephrin Ab

Question 10

dysregulation of alternative complement

Answer 10

DDD/C3 glomerulonephritis (previously MPGN II)

Question 11

c-ANCA and p-ANCA other names

Answer 11

c-ANCA - PR3-ANCA
p-ANCA - MPO-ANCA

Question 12

lipoid nephrosis

Answer 12

minimal change dse

Question 13

allele in Africans assoc. with FSGS, HIV-assoc, COVID-19

what variant

Answer 13

APOL1

collapsing variant

Question 14

inherited FSGS gene
congenital nephrotic syndrome of Finnish type

Answer 14

NPHS1 (nephrin)

Question 15

inherited FSGS gene
AR
steroid-resistant nephrotic syndrome of childhood onset

Answer 15

NPHS2

Question 16

AD FSGS

Answer 16

ACTN4 (a-actinin 4)
INF2 (inverted formin 2)

Question 17

adult onset FSGS

Answer 17

TRP6

Question 18

biomarker of DDD

Answer 18

apo E

Question 19

intramembranous dense deposits

Answer 19

C3 glomerulopathies inc. DDD

Question 20

assoc. with celiac dse

Answer 20

IgA neph

Question 21

basket weave on EM

Answer 21

Alport
X-linked
thin basement membrane neph

Question 22

lupus nephritis

Answer 22

I - minimal mesangial -LC

II - mesangial prolif

III - focal - mesangial + endo, <50%, RBC cast

IV - diffuse - MC, mesangial + endo + epi, >50%, wire loop

V - membranous - diffuse thickening of capillary walls

VI - advanced sclerosing - 90%

Question 23

essential mixed cryoglobulinemia

Answer 23

Hep C
MPGN

Question 24

NSAID glomerulopathies

Answer 24

minimal change dse, membranous nephropathy

Question 25

area affected in ischemic ATN

Answer 25

patchy, prox tubule, ascending loop

Question 26

area affected in toxic ATN

Answer 26

proximal tubule

Question 27

nephrosclerosis assoc with

Answer 27

HTN

Question 28

gene in ARPKD

Answer 28

PKHD1 fibrocystin

Question 29

gene in ADPKD

Answer 29

PKD1, PKD2 polycystin

Question 30

clear cell CA arise in

Answer 30

proximal tubule

Question 31

papillary RCC arise in

Answer 31

distal tubule

Question 32

which invades renal vein

Answer 32

clear cell RCC

Question 33

YWHAE-NUTM2B fusion

Answer 33

clear cell sarcoma HG ESS

Question 34

GCNIS to GCT mutation

Answer 34

reduplication of 12p (isochromosome)

Question 35

spermatocytic tumor mutation

Answer 35

9q gain, DMRT1 (+)KIT, SALL4

Question 36

non-GCNIS

Answer 36

spermtocytic tumor yolk sac, prepubertal teratoma, prepubertal