Diplo > CVS > Flashcards

CVS Flashcards

(59 cards)

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1
Q

extracellular amyloid

A

transthyretin

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2
Q

heart failure with reduced ejection fraction

A

40%

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3
Q

liver necrosis pattern in left-sided heart failure

A

centrilobular necrosis

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4
Q

gene involved in DiGeorge

A

TBX1 deletion - regulates neural crest migration

4th branchial arch, 3rd and 4th pharyngeal pouches

ch 22q11.2

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5
Q

gene in bicuspid aortic valve
in TOF

A

NOTCH1
JAG1, NOTCH2

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6
Q

bony changes in tips of fingers and toes in right-to-left shunts

A

hypertrophic osteoarthropathy

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7
Q

dev’t of atrial septum

A

septum primum
osteum primum
ostium secundum
septum secundum (90% of ASD)
foramen ovale

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8
Q

when and percent of closing of foramen ovale

A

2yrs, 80%

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9
Q

VSD types and percent

A

membranous interventricular 90%
infundibular below pulmo valve 10%

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10
Q

PDA becomes

A

ligamentum arteriosum

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11
Q

hypoplastic left heart syndrome

A

aortic stenosis causes hypoplasia of left ventricle and ascending aorta

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12
Q

irreversible cell injury

A

20-40 min

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13
Q

full extent of infarct

A

6-12 hrs

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14
Q

early coag necrosis

A

4-12 hrs

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15
Q

pyknosis of nuclei, hyper eosinophilia

A

12-24 hrs

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16
Q

mottling w/ yellow tan infarct, brisk neutrophils

A

1-3 days

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17
Q

hyperemic border, macrophages

A

3-7 days

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18
Q

well-developed phagocytosis, granulation at margins

A

7-10 days

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19
Q

new vessels and collagen

A

10-14 days

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20
Q

gray white scar, inc. collagen

A

2-8 wks

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21
Q

complete scar, dense collagenous scar

A

> 2 mos

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22
Q

stain to assess necrosis

A

triphenyl tetrazolium chloride

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23
Q

irreversible damaged myocytes after reperfusion

A

contraction band necrosis

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24
Q

troponins rise, peak, elevated

Study These Flashcards
A

2-4 hrs
24-48 hrs
7-10 days

25
pericarditis weeks after MI due to antibodies
Dressler syndrome
26
myocardial rupture risk factors
older than 60 female anterior or lateral wall no LVH first MI
27
LVH
>500g, 2cm
28
irregular thickenings in left atrium
MacCallum plaques
29
IE in previously normal valves, IV drug users
Staph aureus
30
IE in deformed valves
Strep viridans
31
prostethic valve 1-2 mos after, 1 yr after
S. aureus and epidermidis S aureus and strep
32
glistening white intimal plaque-like thickenings
carcinoid syndrome
33
anthracycline and sarcoidosis cardiomyopathy
dilated
34
Friedrich ataxia cardiomyopathy
hypertrophic
35
DCM causes
titin - AD dystrophin - X-linked coxsackie B alcohol cobalt catecholamines
36
titin DCM
ninja star >5% myocytes
37
ARVH genes and syndrome
plakoglobin, IF desmin, desmoglein, desmoplakin, plakophilin-2 Naxos syndrome - hyperkeratosis of plantar and palmar
38
HCM and DCM differences
HCM - sarcomere protein, GOF DCM - cytoskeletal protein, LOF
39
genes in HCM
MYBP-C B-MHC/MYH7
40
RCM endomyocardial fibrosis with eosinophilic infiltrates
Loeffler endomyocarditis
41
MC form of RCM
endomyocardial fibrosis
42
endocardial fibroelastosis gene
tafazzin - mitochondrial inner memb integrity
43
AD transthyretin mutation
isoleucine to valine position 122
44
MC helminthic disease assoc. with myocarditis
Trichinella spiralis
45
concretio cordis
plaster mold constrictive pericarditis
46
mutation in primary angiosarcoma and undiff sarcoma
MDM2 oncogene amplification
47
myxomas syndrome, gene
left atrium McCune Albright GNAS1 GOF Carney complex PRKAR1A LOF spider cells
48
rhabdomyomas gene
TSC1 hamartin TSC2 tuberin
49
mot impt long-term limitation for cardiac transplant
allograft vasculopathy
50
criteria of myocarditis
inflam infiltrates and myocyte necrosis/degeneration Dallas criteria
51
lower tricuspid
Ebstein anomaly
52
Gamma-Gandy bodies seen in
myxomas
53
stains for mesothelial/monocytic incidental cardiac excrescences (MICE)
CK, CD68
54
angiosarcoma location
right atrium
55
stains for cystic tumor of AV nodal region
CK, CEA, B72.3
56
DeBakey
I - ascending aorta and beyond II - ascending aorta only IIIA - descending aorta up to above diaphragm IIIB - up to below diaphragm
57
distal aortic occlusive thrombosis
Leriche syndrome
58
congenital idiopathic lymphedema
Milroy disease - AD
59
lymph stain
podoplanin (D2-40)
Diplo
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